Abstract: The present disclosure relates generally to protein fusions of Factor H (FH) and Fc, where the fusions include variant linkers, additional N-terminal amino acids, and other variants of the linear structure and amino acid sequences that provide the enhanced microbicidal efficacy and/or manufacturability of the proteins. The present disclosure also provides compositions comprising these protein fusions or their encoding polynucleotide sequences, methods for their preparation, including recombinant production in plant hosts, and the use of these protein fusions for the reduction or eradication of pathogenic microbes in organisms, including prophylactic or therapeutic treatment of mammals, such as humans, for diseases caused by pathogenic microbes, including Lyme disease.

Abstract: Chimeric toxin receptor proteins having a toxin receptor associated with an immunoglobulin complex having least a portion of an immunoglobulin heavy chain and at least a portion of an immunoglobulin light chain are described. Such chimeric toxin receptor proteins have improved stability as compared to chimeric toxin receptor proteins lacking the light chain. Anthrax and botulinum chimeric toxin receptor proteins with increased stability are also described.

Abstract: Immunoadhesins active against toxins and pathogens are described, with specific examples directed to immunoadhesins for thwarting pathogens such as anthrax and the common cold. The immunoadhesin-receptor ligand principle can be employed to counter virtually any pathogen, toxicant or toxin, including, e.g., natural and synthetic metabolic poisons.

Abstract: This invention provides compositions and methods for the transformation of plastids of plant cells with multiple genes, and proper association or assembly of multimeric proteins that are heterologous to the plastids of plant cells. A plasmid construct encoding all of the individual polypeptide components of the multimeric protein is provided. Stable integration of the heterologous coding sequences into the plastid genome of the target plant is accomplished through homologous recombination. The present invention achieves assembly of immunoglobulin heavy and light chains, with covalent bonding between the chains, into immunologically active immunoglobulins in the chloroplast.