Patents by Inventor Keizo Kova

Keizo Kova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of taxol enhancers
    Patent number: 7652168
    Abstract: Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: January 26, 2010
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Shoujun Chen, Lijun Sun, Zhi-Qiang Xia, Keizo Kova, Mitsunori Ono
  • Synthesis of taxol enhancers
    Publication number: 20090005594
    Abstract: Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.
    Type: Application
    Filed: August 29, 2008
    Publication date: January 1, 2009
    Inventors: Shoujun Chen, Lijun Sun, Zhi-Qiang Xia, Keizo Kova, Mitsunori Ono
  • 1-glyoxylamide indolizines for treating cancer
    Publication number: 20040214850
    Abstract: Disclosed is a compound represented by Structural Formula (I): 1
    Type: Application
    Filed: May 20, 2004
    Publication date: October 28, 2004
    Applicant: Synta Pharmaceuticals Corp.
    Inventors: Keizo Kova, Lijun Sun, Mitsunori Ono, Weiwen Ying, Hao Li