Patents by Inventor Keizo Koya

Keizo Koya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030119914
    Abstract: Disclosed is a compound represented by the Structural Formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: June 26, 2003
    Applicant: Shionogi BioResearch Corp.
    Inventors: Keizo Koya, Lijun Sun, Shoujun Chen, Noriaki Tatsuta, Yaming Wu, Mitsunori Ono
  • Publication number: 20030096836
    Abstract: Disclosed is a compound represented by Structural Formula (I): 1
    Type: Application
    Filed: August 29, 2002
    Publication date: May 22, 2003
    Applicant: SBR Pharmaceuticals Corp.
    Inventors: Keizo Koya, Lijun Sun, Mitsunori Ono, David James, Weiwen Ying, Shoujun Chen
  • Publication number: 20030092751
    Abstract: Disclosed is an anti-cancer compound represented by Structural Formula (I): 1
    Type: Application
    Filed: August 29, 2002
    Publication date: May 15, 2003
    Applicant: SBR Pharmaceuticals Corp.
    Inventors: Keizo Koya, Lijun Sun, Mitsunori Ono, Guiqing Liang, David James, Hao Li, Zhi-Qiang Xia
  • Publication number: 20030069225
    Abstract: Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound.
    Type: Application
    Filed: July 10, 2002
    Publication date: April 10, 2003
    Applicant: Shionogi BioResearch Corp.
    Inventors: Shoujun Chen, Lijun Sun, Zhi-Qiang Xia, Keizo Koya, Mitsunori Ono
  • Patent number: 6541062
    Abstract: This invention relates to a water-soluble soybean-based extract including one or more isoflavone glycosides. Also described is a method of preparing such a water-soluble soybean-based extract.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: April 1, 2003
    Inventors: Mitsunori Ono, Keizo Koya, Noriaki Tatsuta, Naoto Yamaguchi, Lan Bo Chen
  • Publication number: 20030045518
    Abstract: One embodiment of the present invention is a compound represented by the Structural Formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: March 6, 2003
    Applicant: Shionogi BioResearch Corp.
    Inventors: Keizo Koya, Lijun Sun, Shoujun Chen, Noriaki Tatsuta, Yaming Wu, Mitsunori Ono, Zhi-Qiang Xia
  • Patent number: 6458406
    Abstract: This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also included is a method of preparing such a water-soluble bean-based extract.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 1, 2002
    Inventors: Mitsunori Ono, Keizo Koya, Noriaki Tatsuta, Naoto Yamaguchi, Lan Bo Chen
  • Patent number: 6433199
    Abstract: The invention relates to a quinone derivative of the following formula: which is capable of converting into two alkylating agents upon bioreduction. Substituents A, B, C, and D are as described herein.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: August 13, 2002
    Assignee: Shionogi BioResearch Corporation
    Inventors: Mitsunori Ono, Keizo Koya, Lijun Sun, Yumiko Wada, Wojciech Wrona, Natalie Dales, Xueliang Tao, Sylvia Holden
  • Publication number: 20020048627
    Abstract: This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also disclosed is a method of preparing such a water-soluble bean-based extract.
    Type: Application
    Filed: November 13, 2001
    Publication date: April 25, 2002
    Inventors: Mitsunori Ono, Keizo Koya, Noriaki Tatsuta, Naoto Yamaguchi, Lan Bo Chen
  • Publication number: 20010031306
    Abstract: This invention relates to a water-soluble soybean-based extract including one or more isoflavone glycosides. Also disclosed is a method of preparing such a water-soluble soybean-based extract.
    Type: Application
    Filed: December 18, 2000
    Publication date: October 18, 2001
    Inventors: Mitsunori Ono, Keizo Koya, Noriaki Tatsuta, Naoto Yamaguchi, Lan Bo Chen
  • Patent number: 6137003
    Abstract: The present invention relates to bis(haloethyl)aminobenzene derivatives featured by having carboxyl-containing moiety and one other moiety at the ortho position with respect to the bis(haloethyl)amino substituent of the benzene ring. The moiety at the ortho position can be alkyl, cycloalkyl, heterocycloalkyl, aryl heteroaryl, alkyl(cycloalkyl), alkyl(heterocycloalkyl), alkyl(heteroaryl), alkyl(aryl), --(--O-alkyl).sub.2-5 or --Y.sup.1 --Y.sup.2 in which Y.sup.1 is O, S, or N(R.sup.5) wherein R.sup.5 is hydrogen or alkyl, and Y.sup.2 is alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroacryl, alkyl(cycloalkyl), alkyl(hetero-cycloalkyl), alkyl(aryl), or alkyl(heteroaryl).
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: October 24, 2000
    Assignee: Shionogi BioResearch
    Inventors: Mitsunori Ono, Keizo Koya, Lijun Sun, Wojciech Wrona, Sylvia Holden, Noriaki Tatsuta
  • Patent number: 5969133
    Abstract: A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive alkylating moiety and the bioreductive moiety.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: October 19, 1999
    Assignee: Shiongi BioResearch Corp.
    Inventors: Mitsunori Ono, Keizo Koya, Lijun Sun, Yumiko Wada, Wojciech Wrona, Natalie Dales, Xueliang Tao, Sylvia Holden
  • Patent number: 5618831
    Abstract: A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: April 8, 1997
    Assignees: Fuji Photo Film Co., Ltd., Dana Farber Cancer Institute
    Inventors: Tadao Shishido, Masayuki Kawakami, Akihiko Ikegawa, Toshinao Ukai, Keizo Koya, Lan B. Chen
  • Patent number: 5599825
    Abstract: There are provided methine compounds having the following structure and their analogs, with a high solubility and are usefull as an active ingredient for pharmaceutical composition for treatment of cancer: ##STR1##
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: February 4, 1997
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Noriaki Tatsuta, Akihiko Okegawa, Masayuki Kawakami, Keizo Koya
  • Patent number: 5424442
    Abstract: A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: June 13, 1995
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Keizo Koya, Toshinao Ukai, Haruo Takei
  • Patent number: 5250692
    Abstract: A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: October 5, 1993
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Keizo Koya, Toshinao Ukai, Haruo Takei
  • Patent number: 5096801
    Abstract: A novel color image recording method is provided, which comprises exposing to light a light-sensitive material obtained by dispersing a composition containing at least a photopolymerization initiator, a color image-forming substance and a polymerizable compound in a hydrophilic binder and then coating said dispersion on a support, subjecting said polymerizable compound in the exposed portions to polymerization, and then (a) eluting said color image-forming substance contained in the unpolymerized polymerizable compound in the unexposed portions with an alkaline aqueous solution or (b) subjecting said color image-forming substance contained in the unpolymerized polymerizable compound in the unexposed portions to chemical change so that it is discolored, thereby forming dye images.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: March 17, 1992
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Keizo Koya, Kozo Sato, Yoshiharu Yabuki, Hiroshi Hara
  • Patent number: 5075208
    Abstract: A silver halide photographic material containing a compound having a structure represented by formula (I) ##STR1## wherein EAG represents a group capable of accepting an electron from a reducing material; E represents an electron-attracting group; R.sup.3 represents an atomic group necessary for forming a 5-membered to 8-membered single ring or condensed ring by combining with the carbon atom carrying EAG and E; ETG represents an electron-transmitting group; n represents 0 or 1; R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a hydrocarbon group, a heterocyclic group, or a single bond for forming a ring with EAG; Time represents a group releasing PUG upon cleavage of the bond between the carbon atom carrying R.sup.1 and R.sup.2 and Time; t represents 0 or 1; and PUG represents a photographically useful group.
    Type: Grant
    Filed: September 11, 1990
    Date of Patent: December 24, 1991
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Hiroyuki Watanabe, Keizo Koya, Yasuhiro Yoshioka, Koki Nakamura
  • Patent number: 5073473
    Abstract: A method for forming an image by silver salt diffusion transfer is described, comprises processing an imagewise exposed photosensitive element provided with a layer of photosensitive silver halide emulsion on a support, and an image-receiving element provided with an image-receiving layer containing a silver-precipitating agent on a support, with an alkali processing composition in the presence of a silver halide solvent, to convert at least part of the unexposed silver halide in the emulsion layer into a transferable silver complex salt, to transfer at least part of said complex salt into the image-receiving layer, and to form an image in the image-receiving layer; the processing being carried out in the presence of at least one compound as described.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: December 17, 1991
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Keizo Koya, Yoshio Idota
  • Patent number: 5071729
    Abstract: A silver halide photographic material comprising a support having provided thereon at least one silver halide emulsion layer, wherein the silver halide photographic material contains a compound having discoloration inhibitory activity represented by formula (I):PWR--Time).sub.t MCAP (I)wherein PWR represents a group capable of releasing (Time).sub.t -MCAP upon being reduced; Time represents a group which is released from PWR in the form of (Time).sub.t -MCAP and then releases MCAP through a subsequent reaction; t represents 0 or 1; and MCAP represents a group having discoloration inhibitory activity.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: December 10, 1991
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Keizo Koya, Shigeru Ohno, Yoshisada Nakamura