Patents by Inventor Kelley J. Bentley

Kelley J. Bentley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding mammalian phosphodiesterases
    Patent number: 7122363
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: October 17, 2006
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Human cGMP-stimulated cyclic nucleotide phosphodiesterase
    Patent number: 6642040
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: November 4, 2003
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Assay methods using DNA encoding mammalian phosphodiesterases
    Patent number: 6015677
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: January 18, 2000
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • DNA encoding mammalian phosphodiesterases
    Patent number: 5602019
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: February 11, 1997
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg