Patents by Inventor Kelli E. Smith

Kelli E. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7132248
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: November 7, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Kelli E. Smith, David Linemeyer, Christophe P. G. Gerald, Theresa Branchek, Richard L. Weinshank, Carlos Forray
  • Patent number: 7060449
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: June 13, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Kelli E. Smith, Christophe P. G. Gerald, Richard L. Weinshank, David Linemeyer, Theresa Branchek, Carlos Forray
  • Patent number: 7022489
    Abstract: This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: April 4, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Jonathan A. Bard, Beth Borowsky, Kelli E. Smith, Theresa A. Branchek, Christophe P. G. Gerald, Kenneth A. Jones
  • Patent number: 6790656
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: September 14, 2004
    Assignee: Synaptic Pharmaceutical Corporation
    Inventors: Kelli E. Smith, Christophe P. G. Gerald, Richard L. Weinshank, David Linemeyer, Theresa Branchek, Carlos Forray
  • Publication number: 20030215823
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Application
    Filed: October 31, 2002
    Publication date: November 20, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Kelli E. Smith, David Linemeyer, Christophe P. G. Gerald, Theresa Branchek, Richard L. Weinshank, Carlos Forray
  • Publication number: 20030158401
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF13 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF13 receptor and having a sequence identical to the sequence of either one of the human SNORF13a receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7hSNORF13a-f (Patent Deposit Designation No. PTA-______), the human SNORF13b receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13b-f (Patent Deposit Designation No. PTA-______), the human SNORF13c receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13c-f (Patent Deposit Designation No. PTA-______), or the human SNORF13d receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13d-f (Patent Deposit Designation No.
    Type: Application
    Filed: October 21, 2002
    Publication date: August 21, 2003
    Inventors: Marie Sudam Pathirana, Kristine L. Ogozalek, Beth E. Borowsky, James A. Bonini, Kelli E. Smith
  • Publication number: 20030143729
    Abstract: This invention provides isolated nucleic acid molecules encoding two mammalian GABA transporters, a mammalian taurine transporter and two human GABA transporters; methods of isolating these nucleic acid molecules and vectors comprising such nucleic acid molecules as well as mammalian cells comprising such vectors. Nucleic acid probes for detecting nucleic acid molecules encoding mammalian or human GABA transporters, or mammalian or human taurine transporters; antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian GABA or taurine transporter or human GABA or taurine transporter; and antibodies to the mammalian GABA or taurine transporters, or human GABA or taurine transporters are provided. Pharmaceutical compounds related to mammalian GABA or taurine transporters and to human GABA or taurine transporters are provided.
    Type: Application
    Filed: April 30, 2001
    Publication date: July 31, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Kelli E. Smith, Laurence A. Borden, Richard L. Weinshank, Paul R. Hartig
  • Publication number: 20030129702
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Application
    Filed: November 18, 2002
    Publication date: July 10, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Kelli E. Smith, Christophe P.G. Gerald, Richard L. Weinshank, David Linemeyer, Theresa Branchek, Carlos Forray
  • Publication number: 20030124138
    Abstract: This invention provides an isolated nucleic acid encoding a human hp15a receptor, a purified human hp15a receptor, vectors comprising isolated nucleic acid encoding a human hp15a receptor, cells comprising such vectors, antibodies directed to a human hp15a receptor, nucleic acid probes useful for detecting nucleic acid encoding a human hp15a receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a human hp15a receptor, transgenic, nonhuman animals which express DNA encoding a normal or mutant human hp15a receptor, methods of isolating a human hp15a receptor, methods of treating an abnormality that is linked to the activity of the human hp15a receptor, as well as methods of determining binding of compounds to human hp15a receptors.
    Type: Application
    Filed: December 19, 2001
    Publication date: July 3, 2003
    Inventors: Kelli E. Smith, Richard Weinshank
  • Patent number: 6586191
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: July 1, 2003
    Assignee: Synaptic Pharmaceutical Corporation
    Inventors: Kelli E. Smith, David Linemeyer, Christophe P. G. Gerald, Theresa Branchek, Richard L. Weinshank, Carlos Forray
  • Publication number: 20030119096
    Abstract: This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Application
    Filed: December 3, 2001
    Publication date: June 26, 2003
    Inventors: Jonathan A. Bard, Beth Borowsky, Kelli E. Smith
  • Publication number: 20030105317
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF65 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF65 receptor and having a sequence identical to the sequence of the human SNORF65 receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF65-f (Patent Deposit Designation No. PTA 1226). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF65 receptor, wherein the human SNORF65 receptor comprises an amino acid sequence identical to the sequence of the human SNORF65 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (SEQ ID NO: 1).
    Type: Application
    Filed: August 26, 2002
    Publication date: June 5, 2003
    Inventors: Kelli E. Smith, Yong Quan
  • Publication number: 20030082641
    Abstract: This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Application
    Filed: January 26, 2001
    Publication date: May 1, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Jonathan A. Bard, Beth Borowsky, Kelli E. Smith, Theresa A. Branchek, Christophe P.G. Gerald, Kenneth A. Jones
  • Publication number: 20030082672
    Abstract: This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Application
    Filed: July 23, 1997
    Publication date: May 1, 2003
    Inventors: KELLI E. SMITH, DAVID LINEMEYER, CHRISTOPHE GERALD, THERESA BRANCHEK, RICHARD L. WEINSHANK, CARLOS FORRAY
  • Publication number: 20030078407
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF53 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF53 receptor and having a sequence identical to the sequence of the human SNORF53 receptor-encoding nucleic acid contained in plasmid pEXJ-hSNORF53-f (Patent Deposit Designation No. PTA ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF53 receptor, wherein the human SNORF53 receptor comprises an amino acid sequence identical to the sequence of the human SNORF53 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1E (SEQ ID NO: 1).
    Type: Application
    Filed: August 30, 2002
    Publication date: April 24, 2003
    Inventors: Kelli E. Smith, Kellie M. Boitz, Kristine L. Ogozalek, Beth E. Borowsky
  • Publication number: 20030027254
    Abstract: This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
    Type: Application
    Filed: December 3, 2001
    Publication date: February 6, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Jonathan A. Bard, Beth Borowsky, Kelli E. Smith, Theresa A. Branchek, Christophe P.G. Gerald, Kenneth A. Jones
  • Publication number: 20030022839
    Abstract: This invention provides a method of treating a subject suffering from an abnormality which comprises administering to the subject an amount of a SNORF11 receptor agonist effective to treat the subject's abnormality. This invention further provides a method of treating pain, particularly chronic pain, chronic inflammatory pain and arthritic pain, which comprises administering to the subject an amount of a SNORF11 receptor agonist effective to treat the subject's pain.
    Type: Application
    Filed: July 2, 2002
    Publication date: January 30, 2003
    Inventors: Beth E. Borowsky, Yong Quan, Kelli E. Smith
  • Publication number: 20030023072
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF9 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF9 receptor and having a sequence identical to the sequence of the human SNORF9 receptor-encoding nucleic acid contained in plasmid pEXJ-hSNORF9-f (Patent Deposit Designation No. PTA ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF9 receptor, wherein the human SNORF9 receptor comprises an amino acid sequence identical to the sequence of the human SNORF9 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (SEQ ID NO: 1).
    Type: Application
    Filed: June 12, 2002
    Publication date: January 30, 2003
    Inventors: Yong Quan, Kelli E. Smith
  • Publication number: 20020198369
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF12 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF12 receptor and having a sequence identical to the sequence of the human SNORF12 receptor-encoding nucleic acid contained in plasmid pcDNA3.1-hSNORF12-f (ATCC Accession No. ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF12 receptor, wherein the human SNORF12 receptor comprises an amino acid sequence identical to the sequence of the human SNORF12 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (Seq. I.D. No. 1).
    Type: Application
    Filed: January 10, 2002
    Publication date: December 26, 2002
    Inventors: Kelli E. Smith, Marie Sudam Pathirana, Hla Kyaw, Beth E. Borowsky
  • Publication number: 20020151704
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF10 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF10 receptor and having a sequence identical to the sequence of the human SNORF10 receptor-encoding nucleic acid contained in plasmid pEXJ-hSNORF10-f (ATCC Accession No. ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF10 receptor, wherein the human SNORF10 receptor comprises an amino acid sequence identical to the sequence of the human SNORF10 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1D (Seq. I.D. No. 1).
    Type: Application
    Filed: October 22, 2001
    Publication date: October 17, 2002
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Hla Kyaw, Marie Sudam Pathirana, Kelli E. Smith