Patents by Inventor Kellie A. Benzow
Kellie A. Benzow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200109422Abstract: Provided herein are precise gene replacement methods and transgenic non-human animals produced by such methods, in which an endogenous non-human animal gene of interest is precisely replaced with a human syntenic gene. The resulting genetically modified non-human animals are useful for evaluating molecular impact of pathogenic mutations within the context of the human genomic sequence in which they occur in patients and for screening for potential therapeutic agents.Type: ApplicationFiled: October 8, 2019Publication date: April 9, 2020Inventors: Michael Koob, Kellie Benzow
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Patent number: 9556488Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: GrantFiled: April 28, 2014Date of Patent: January 31, 2017Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Publication number: 20140322711Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: ApplicationFiled: April 28, 2014Publication date: October 30, 2014Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Laura P.W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Patent number: 8748096Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: GrantFiled: August 20, 2012Date of Patent: June 10, 2014Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Publication number: 20130230849Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: ApplicationFiled: August 20, 2012Publication date: September 5, 2013Applicant: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Publication number: 20130029335Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: ApplicationFiled: August 20, 2012Publication date: January 31, 2013Applicant: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Patent number: 8247173Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: GrantFiled: June 21, 2010Date of Patent: August 21, 2012Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Publication number: 20100317015Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: ApplicationFiled: June 21, 2010Publication date: December 16, 2010Applicant: Regents of the University of MinnesotaInventors: LAURA P.W. RANUM, MICHAEL D. KOOB, KELLIE A. BENZOW, MELINDA L. MOSELEY-ALLDREDGE
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Patent number: 7741458Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: GrantFiled: February 24, 2003Date of Patent: June 22, 2010Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Patent number: 7118893Abstract: The present invention provides diagnostic methods of identifying individuals at risk and not at risk of developing spinocerebellar ataxia type 7. The present invention also provides for methods for identifying expanded repeats, and the DNA flanking the expanded repeats, from genomic DNA.Type: GrantFiled: February 3, 2003Date of Patent: October 10, 2006Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Melinda L. Moseley-Alldredge, Kellie A. Benzow
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Publication number: 20030235841Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: ApplicationFiled: February 24, 2003Publication date: December 25, 2003Applicant: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Publication number: 20030180768Abstract: The present invention provides diagnostic methods of identifying individuals at risk and not at risk of developing spinocerebellar ataxia type 7. The present invention also provides for methods for identifying expanded repeats, and the DNA flanking the expanded repeats, from genomic DNA.Type: ApplicationFiled: February 3, 2003Publication date: September 25, 2003Applicant: Regents of the University of MinnesotaInventors: Laura P.W. Ranum, Michael D. Koob, Melinda L. Moseley-Alldredge, Kellie A. Benzow
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Patent number: 6524791Abstract: The present invention provides an isolated nucleic acid molecule containing a a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: GrantFiled: October 28, 1998Date of Patent: February 25, 2003Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Patent number: 6514755Abstract: The present invention provides diagnostic methods of identifying individuals at risk and not at risk of developing spinocerebellar ataxia type 7. The present invention also provides for methods for identifying expanded repeats, and the DNA flanking the expanded repeats, from genomic DNA.Type: GrantFiled: October 6, 2000Date of Patent: February 4, 2003Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Melinda L. Mosely-Alldredge, Kellie A. Benzow
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Patent number: 6280938Abstract: The present invention provides diagnostic methods of identifying individuals at risk and not at risk of developing spinocerebellar ataxia type 7. The present invention also provides for methods for identifying expanded repeats, and the DNA flanking the expanded repeats, from genomic DNA.Type: GrantFiled: August 18, 1998Date of Patent: August 28, 2001Assignee: Regents of the University of MinnesotaInventors: Laura P. W. Ranum, Michael D. Koob, Melinda L. Moseley-Alldredge, Kellie A. Benzow