Patents by Inventor Kelly A. Frazer

Kelly A. Frazer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170342504
    Abstract: A method to detect ovarian cancer is provided that employs probes and/or primers to detect certain RNA isoform transcripts, as well as kits therefor.
    Type: Application
    Filed: May 24, 2017
    Publication date: November 30, 2017
    Inventors: Christian Barrett, Dennis A. Carson, Kelly Frazer
  • Patent number: 9611330
    Abstract: In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded RNA-specific adenosine deaminases, or ADAR, enzymes. In alternative embodiments, the invention provides compositions and methods for treating, ameliorating or preventing diseases and conditions responsive to the inhibition of cell differentiation and/or self-renewal of dysfunctional cells, cancer cells, leukemia cells, hematopoietic stem cells or cancer stem cells, e.g., leukemia or Chronic Myeloid Leukemia (CML). In alternative embodiments, the invention provides compositions and methods for inhibiting a Sonic Hedgehog (Shh) pathway, e.g., by using a Smoothened (SMO) protein inhibitor.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: April 4, 2017
    Assignee: The Regents of the University of California
    Inventors: Catriona H. Jamieson, Qingfei Jiang, Kelly A. Frazer, Christian L. Barrett, Anil Sadarangani, Angela Court, Leslie Crews Robertson
  • Publication number: 20140302059
    Abstract: In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded RNA-specific adenosine deaminases, or ADAR, enzymes. In alternative embodiments, the invention provides compositions and methods for treating, ameliorating or preventing diseases and conditions responsive to the inhibition of cell differentiation and/or self-renewal of dysfunctional cells, cancer cells, leukemia cells, hematopoietic stem cells or cancer stem cells, e.g., leukemia or Chronic Myeloid Leukemia (CML). In alternative embodiments, the invention provides compositions and methods for inhibiting a Sonic Hedgehog (Shh) pathway, e.g., by using a Smoothened (SMO) protein inhibitor.
    Type: Application
    Filed: September 7, 2012
    Publication date: October 9, 2014
    Inventors: Catriona H. Jamieson, Qingfei Jiang, Kelly A. Frazer, Christian L. Barrett, Anil Sadarangani, Alice Shih, Angela Court, Leslie Crews Robertson
  • Publication number: 20090186347
    Abstract: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided.
    Type: Application
    Filed: May 9, 2008
    Publication date: July 23, 2009
    Inventors: David R. Cox, Kelly A. Frazer, David A. Hinds, Craig L. Hyde, John F. Thompson
  • Patent number: 6997061
    Abstract: A non-contact method for evaluating stress in a substrate. An impurity is non-uniformly introduced into at least one region of a crystalline substrate. The crystalline substrate is subjected to physical stress. Fluorescence producing energy is directed at the crystalline substrate. A fluorescence produced by the crystalline substrate is measured. The fluorescence is correlated with the stress on the crystalline substrate.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: February 14, 2006
    Assignee: The Johns Hopkins University
    Inventors: Joseph A. Miragliotta, Kenneth R. Grossman, R. Kelly Frazer, Robert J. Bamberger, Jr.
  • Patent number: 6963805
    Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: November 8, 2005
    Assignee: Perlegen Sciences, Inc.
    Inventors: Kelly A. Frazer, Nila Patil, John Sheehan
  • Patent number: 6891031
    Abstract: The present invention provides CNS sequences that regulate the cytokine gene expression, expression cassettes and vectors comprising or lacking the CNS sequences, host cells and non-human transgenic animals comprising the CNS sequences or lacking the CNS sequences. The present invention also provides methods for identifying compounds that modulate the functions of CNS sequences as well as methods for diagnosing defects in the CNS sequences of patients.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: May 10, 2005
    Assignee: The Regents of the University of California
    Inventors: Kelly A. Frazer, Edward M. Rubin, Gabriela G. Loots
  • Publication number: 20050003410
    Abstract: The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.
    Type: Application
    Filed: May 12, 2004
    Publication date: January 6, 2005
    Applicant: Perlegen Sciences, Inc.
    Inventors: Kelly Frazer, David Cox, Heng Tao, Krishna Pant, Geoffrey Nilson
  • Publication number: 20040229224
    Abstract: The invention provides methods of analyzing genes for differential relative allelic expression patterns. Haplotype blocks throughout the genomes of individuals are analyzed to identify haplotype patterns that are associated with specific differential relative allelic expression patterns. Haplotype blocks that contain associated haplotype patterns may be further investigated to identify genes or variants of genes involved in differential relative allelic expression patterns.
    Type: Application
    Filed: May 13, 2003
    Publication date: November 18, 2004
    Applicant: Perlegen Sciences, Inc.
    Inventors: Kelly A. Frazer, David R. Cox, Heng Tao, Krishna Pant, Geoffrey Nilsen
  • Publication number: 20040211264
    Abstract: A non-contact method for evaluating stress in a substrate. An impurity is non-uniformly introduced into at least one region of a crystalline substrate. The crystalline substrate is subjected to physical stress. Fluorescence producing energy is directed at the crystalline substrate. A fluorescence produced by the crystalline substrate is measured. The fluorescence is correlated with the stress on the crystalline substrate.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 28, 2004
    Inventors: Joseph A. Miragliotta, Kenneth R. Grossman, R. Kelly Frazer, Robert J. Bamberger
  • Patent number: 6763727
    Abstract: A non-contact method for evaluating stress in a substrate. An impurity is non-uniformly introduced into at least one region of a crystalline substrate. The crystalline substrate is subjected to physical stress. Fluorescence producing energy is directed at the crystalline substrate. A fluorescence produced by the crystalline substrate is measured. The fluorescence is correlated with the stress on the crystalline substrate.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: July 20, 2004
    Assignee: The Johns Hopkins University
    Inventors: Joseph A. Miragliotta, Kenneth R. Grossman, R. Kelly Frazer, Robert J. Bamberger, Jr.
  • Publication number: 20030119015
    Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.
    Type: Application
    Filed: May 8, 2002
    Publication date: June 26, 2003
    Applicant: Perlegen Sciences, Inc.
    Inventors: Kelly A. Frazer, Nila Patil, John Sheehan
  • Publication number: 20030017474
    Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.
    Type: Application
    Filed: October 5, 2001
    Publication date: January 23, 2003
    Applicant: Perlegen Sciences, Inc., a Delaware corporation
    Inventors: Kelly A. Frazer, Nila Patil, John Sheehan
  • Publication number: 20020194928
    Abstract: A non-contact method for evaluating stress in a substrate. An impurity is non-uniformly introduced into at least one region of a crystalline substrate. The crystalline substrate is subjected to physical stress. Fluorescence producing energy is directed at the crystalline substrate. A fluorescence produced by the crystalline substrate is measured. The fluorescence is correlated with the stress on the crystalline substrate.
    Type: Application
    Filed: May 20, 2002
    Publication date: December 26, 2002
    Inventors: Joseph A. Miragliotta, Kenneth R. Grossman, R. Kelly Frazer, Robert J. Bamberger
  • Publication number: 20020164634
    Abstract: The invention provides several methods for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids on a nucleic acid probe array. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired property. The resulting nucleic acids in the subset are then applied to the array for various types of analysis. The methods are particularly useful for analyzing populations having a high degree of complexity, for example, chromosomal-derived DNA, or whole genomic DNA, or mRNA population. In addition, such methods allow for analysis of pooled samples.
    Type: Application
    Filed: April 24, 2002
    Publication date: November 7, 2002
    Applicant: Perlegen Sciences, Inc.
    Inventors: Nila Patil, David R. Cox, Charit Pethiyagoda, Kelly A. Frazer
  • Publication number: 20020132290
    Abstract: The present invention provides CNS sequences that regulate the cytokine gene expression, expression cassettes and vectors comprising or lacking the CNS sequences, host cells and non-human transgenic animals comprising the CNS sequences or lacking the CNS sequences. The present invention also provides methods for identifying compounds that modulate the functions of CNS sequences as well as methods for diagnosing defects in the CNS sequences of patients.
    Type: Application
    Filed: February 20, 2001
    Publication date: September 19, 2002
    Inventors: Kelly A. Frazer, Edward M. Rubin, Gabriela G. Loots