Patents by Inventor Kelly Boeneman

Kelly Boeneman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery of nanoparticles to neurons
    Patent number: 8859284
    Abstract: A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: October 14, 2014
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman, Kimihiro Susumu, Michael H. Stewart, Ryan Walters
  • Modular functional peptides for delivery of nanoparticles
    Patent number: 8835172
    Abstract: A peptide directs nanoparticles (such as quantum dots) to the plasma membrane of mammalian cells. A method of delivery of a nanoparticle to a plasma membrane of a cell includes providing to the cell a nanoparticle attached to a peptide configured to direct the nanoparticle the plasma membrane, and allowing the cell to take up the nanoparticle. The nanoparticle can be a FRET donor to an organic dye.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: September 16, 2014
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman
  • Modular functional peptides for the intracellular delivery of nanoparticles
    Patent number: 8796435
    Abstract: Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: August 5, 2014
    Assignees: The United States of America, as represented by the Secretary of the Navy, The University of Chicago
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman
  • Modular Functional Peptides for the Intracellular Delivery of Nanoparticles
    Publication number: 20130158244
    Abstract: Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
    Type: Application
    Filed: February 22, 2013
    Publication date: June 20, 2013
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman
  • Modular Functional Peptides for Delivery of Nanoparticles
    Publication number: 20130130296
    Abstract: A peptide directs nanoparticles (such as quantum dots) to the plasma membrane of mammalian cells. A method of delivery of a nanoparticle to a plasma membrane of a cell includes providing to the cell a nanoparticle attached to a peptide configured to direct the nanoparticle the plasma membrane, and allowing the cell to take up the nanoparticle. The nanoparticle can be a FRET donor to an organic dye.
    Type: Application
    Filed: September 18, 2012
    Publication date: May 23, 2013
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman
  • Delivery of Nanoparticles to Neurons
    Publication number: 20130129627
    Abstract: A peptide attached to a nanoparticles (such as quantum dots) selectively directs the nanoparticles to neurons in a tissue or organism.
    Type: Application
    Filed: November 16, 2012
    Publication date: May 23, 2013
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman, Kimihiro Susumu, Michael H. Stewart, Ryan Walters
  • Modular functional peptides for the intracellular delivery of nanoparticles
    Patent number: 8409858
    Abstract: Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and the uptake and vesicle escape domains, and wherein the peptide, when attached to an extracellular nanoparticle, is effective to induce uptake of the nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: April 2, 2013
    Assignees: The United States of America, as represented by the Secretary of the Navy, The University of Chicago
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Jeffrey R. Deschamps, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman
  • Modular Functional Peptides for the Intracellular Delivery of Nanoparticles
    Publication number: 20110097797
    Abstract: Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and the uptake and vesicle escape domains, and wherein the peptide, when attached to an extracellular nanoparticle, is effective to induce uptake of the nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.
    Type: Application
    Filed: October 20, 2010
    Publication date: April 28, 2011
    Applicant: The Government of United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Igor L. Medintz, Hedi M. Mattoussi, Glyn Dawson, Philip E. Dawson, Juan Bautista Blanco-Canosa, Kelly Boeneman