Abstract: Provided herein are compounds having the structure of Formula I, wherein the compounds comprises a therapeutic agent having the sequence of SEQ ID NO: 35, and the compounds have an anion:cation molar ratio of from about 1:1 to about 1:7, and methods of using thereof for the treatment of metabolic diseases or disorders, including type 1 diabetes, type 2 diabetes, obesity, overweight, and nonalcoholic steatohepatitis, and for reducing weight in a subject in need thereof.

Abstract: Provided herein are compounds having the structure of Formula Ia, wherein the compounds comprise a therapeutic agent having the configuration of [diacid]-[linker]-[an amylin analog], in which the amylin analog has the amino acid sequence of SEQ ID NO: 20, with a proviso that the amino acid sequence comprises one or more of the following amino acid substitutions: N14E, V17R, Y37P, F15E, L16E, V17E, or any combination thereof, and the compounds have an anion: cation molar ratio of from about 1:1 to about 1:3, and methods of using thereof for the treatment of metabolic diseases or disorders, including type 1 diabetes, type 2 diabetes, obesity, overweight, and nonalcoholic steatohepatitis, and for reducing weight in a subject in need thereof.

Abstract: Provided herein are compounds having the structure of Formula Ia, wherein the compounds comprise a therapeutic agent having the sequence of SEQ ID NO: 35, and the compounds have an anion:cation molar ratio of from about 1:1 to about 1:7, and methods of using thereof for the treatment of metabolic diseases or disorders, including type 1 diabetes, type 2 diabetes, obesity, overweight, and nonalcoholic steatohepatitis, and for reducing weight in a subject in need thereof.

Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of GCase proteins, whether in vitro and/or in vivo. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson Disease or related condition resulting from a deficiency in the quantity and/or function of GBA gene product or associated with decreased expression or protein levels of GCase protein.

Abstract: The present disclosure provides a puree of palm and process of making the puree. The puree of palm has reduced sugar, low calorie, various nutrients, and favorable sensory characteristic. The puree can by itself serve as a food product or can also be used as a functional component for beverages and foodstuffs.

Abstract: A sensing device includes a pair of contactless electrodes for placement on a coating on a surface of a structure or within or between one or more coatings on or over the surface of the structure. The electrodes function as sensors when activated to generate a current flow through the electrodes at multiple different frequencies. The sensing device also includes contactless control circuitry co-located with or separate from the electrodes that transmits impedance data generated from the activated electrodes. The impedance data is associated with corrosion condition information of the structure and/or the one or more coatings. A data collection system and display system useable with the sensing device are also described.

Abstract: A sensing device includes a pair of contactless electrodes for placement on a coating on a surface of a structure or within or between one or more coatings on or over the surface of the structure. The electrodes function as sensors when activated to generate a current flow through the electrodes at multiple different frequencies. The sensing device also includes contactless control circuitry co-located with or separate from the electrodes that transmits impedance data generated from the activated electrodes. The impedance data is associated with corrosion condition information of the structure and/or the one or more coatings. A data collection system and display system useable with the sensing device are also described.

Abstract: A method of culturing fastidious bacteria where a conditioned cell culture medium is prepared in which eukaryotic cells have been cultured, but where the medium is substantially free of the cultured cells. Fastidious bacteria are cultured in the medium. The conditioned cell culture medium can contain secreted factors from the cells. These factors promote the growth of the fastidious bacteria. The fastidious bacterial culture is maintained for a time period sufficient for the fastidious bacteria to multiply. The fastidious bacteria are analyzed using PCR, DNA sequencing or microbiology characterization.

Abstract: A method of culturing fastidious bacteria where a conditioned cell culture medium is prepared in which eukaryotic cells have been cultured, but where the medium is substantially free of the cultured cells. Fastidious bacteria are cultured in the medium. The conditioned cell culture medium can contain secreted factors from the cells. These factors promote the growth of the fastidious bacteria. The fastidious bacterial culture is maintained for a time period sufficient for the fastidious bacteria to multiply. The fastidious bacteria are analyzed using PCR, DNA sequencing or microbiology characterization.

Abstract: The present invention provides a biological particle analogue, or biological analogue, that simulates a chosen biological organism or compound. The biological analogue includes a first portion that is not, in and of itself, recognized by the biological detection system, and a second portion, which provides the properties necessary for recognition by the detection system, carried by the first portion. The biological analogue is constructed in such a way as to include some important characteristics of the chosen biological organism or compound, while excluding other undesirable characteristics of the chosen biological organism or compound. The present invention is useful in testing a variety of biological detection systems.

Abstract: The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.

Abstract: The present invention provides propellant formulations for non-pharmaceutical use in dispersing insoluble particles having biological activity, such as bacterial spores and/or biological analogues, using a dispersion device such as a metered-dose inhaler. It is preferred that the propellant formulations of the present invention are chemically compatible with the biological analogues with which they are to be used, have substantially the same specific gravity as the biological analogues, and have sufficient vapor pressure to prevent agglomeration of the biological analogues. Methods of dispersing said biological analogues in accordance with the present invention are also provided.

Abstract: A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.

Abstract: A filter device made of less expensive material than comparable filter devices heretofore has basic filter components plus some unique design aspects and an additional ring component. The ring provides an interface inside the filter which enables the potting compound to adhere to the filter and create a seal between a first and second fluid compartment within the filter. An embedded region of the ring possesses a detailed geometry which helps ensure that a delamination would be localized and unable to propagate from the first to the second compartment, maintaining the structural integrity of the filter device. To ensure that the sealing interface remains intact and free from delamination, the ring is subjected to a surface treatment, which modifies the surface energy of the ring. This modified surface energy of the ring allows the hydrophilic potting compound to more effectively bond to the modified hydrophobic ring.

Abstract: A polyol composition containing a polyester polyol, at least 5 weight % of a compatibilizing agent, based on the weight of the polyol and compatibilizing agent, and a hydrocarbon blowing agent. The compatibilizing agent is one or a combination of a benzoate glycol adduct, a substituted benzoate glycol adduct, a naphthenate glycol adduct, a substituted naphthenate glycol adduct, a toluate glycol adduct, or a substituted toluate glycol adduct. The hydrocarbon blowing agent is selected from cyclopentane, isopentane, n-pentane, 2-chloropropane; 1,1,1,2-tetrafluoroethane (HFC-134a); 1,1,1,3,3-pentafluoropropane (HFC-245fa); and n-propylbromide, or mixtures thereof. The compatibilizing agent improves the miscibility of conventional polyester polyols with hydrocarbon blowing agents. The polyol composition can be reacted with a polyisocyanate to form a foam.

Abstract: A polyol composition containing a polyester polyol, at least 5 weight % of a compatibilizing agent, based on the weight of the polyol and compatibilizing agent, and a hydrocarbon blowing agent. The compatibilizing agent is one or a combination of a benzoate glycol adduct, a substituted benzoate glycol adduct, a naphthenate glycol adduct, a substituted naphthenate glycol adduct, a toluate glycol adduct, or a substituted toluate glycol adduct. The hydrocarbon blowing agent is selected from cyclopentane, isopentane, n-pentane, 2-chloropropane; 1,1,1,2-tetrafluoroethane (HFC-134a); 1,1,1,3,3-pentafluoropropane (HFC-245fa); and n-propylbromide, or mixtures thereof. The compatibilizing agent improves the miscibility of conventional polyester polyols with hydrocarbon blowing agents. The polyol composition can be reacted with a polyisocyanate to form a foam.

Abstract: A filter device made of less expensive material than comparable filter devices heretofore has basic filter components plus some unique design aspects and an additional ring component. The ring provides an interface inside the filter which enables the potting compound to adhere to the filter and create a seal between a first and second fluid compartment within the filter. An embedded region of the ring possesses a detailed geometry which helps ensure that a delamination would be localized and unable to propagate from the first to the second compartment, maintaining the structural integrity of the filter device. To ensure that the sealing interface remains intact and free from delamination, the ring is subjected to a surface treatment, which modifies the surface energy of the ring. This modified surface energy of the ring allows the hydrophilic potting compound to more effectively bond to the modified hydrophobic ring.

Abstract: A polyol solution containing one or a combination of a benzoate glycol adduct, a substituted benzoate glycol adduct, a napthenate glycol adduct, a substituted naphthenate glycol adduct, a toluate glycol adduct, or a substituted toluate glycol adduct, and a closed cell, rigid polymer foam formed as a reaction product of the polyol solution, which foam comprises the reaction product of a polyisocyanate and an isocyanate-reactive component in the presence of a catalyst and a hydrogen-containing blowing agent or mixture of hydrogen-containing blowing agents, wherein the isocyanate-reactive component comprises a mixture of a hydroxy terminated polyester and a polyester comprised of the benzoic acid glycol adduct, toluic acid glycol adduct, or napthoic acid glycol adduct Foams prepared from the mixture have superior thermal conductivity, lower flammability, and higher stability of the emulsified liquid reactants prior to polymerization.

Abstract: A rod gripping device, having a support member with a locking pin hole and a rod receiving hole, where the bores of each hole are situated perpendicular to each other, but parallel to a given plane that bisects the support, and where the bores of the holes intersect to form a common area shared by both bores. When a rod is inserted into the rod receiving bore, so that the rod occupies the common area shared by the bores, a set of angled wedges are situated on either side of the rod, with the wedges being located in the locking pin hole bore. A first wedge has a smooth bore through it, with the second wedge having a threaded bore. A locking pin is inserted through the first smooth bore wedge, which can slide along the shaft of the locking pin to the locking pin handle edge, with the second threaded bore wedge receiving the locking pin's threaded shaft portion.

Abstract: A tank for oil or other hydraulic fluid is kept under a few pounds of air pressure during operation to keep air from being drawn into the fluid and to aid its flow to the pump. The pressure is provided dependably and quickly by a small air pump driven whenever the hydraulic pump is driven. A bleed-off discharge causes prompt dissipation of the pressure on shutdown so as not to cause oil leakage while the associated hydraulic pump is idle. The hydraulic level is below the pump shaft level so there will be no leakage by gravity.