Patents by Inventor Kelly Chibale

Kelly Chibale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-malarial agents
    Patent number: 10214495
    Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: February 26, 2019
    Assignee: University of Cape Town
    Inventors: David Waterson, Michael John Witty, Kelly Chibale, Leslie Street, Diego Gonzalez Cabrera, Tanya Paquet
  • NEW ANTI-MALARIAL AGENTS
    Publication number: 20180194741
    Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
    Type: Application
    Filed: July 13, 2015
    Publication date: July 12, 2018
    Inventors: DAVID WATERSON, MICHAEL JOHN WITTY, KELLY CHIBALE, LESLIE STREET, DIEGO GONZALEZ CABRERA, TANYA PAQUET
  • Anti-malarial agents
    Patent number: 9266842
    Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 23, 2016
    Assignees: MMV MEDICINES FOR MALARIA VENTURE, UNIVERSITY OF CAPE TOWN
    Inventors: Yassir Younis, Kelly Chibale, Michael John Witty, David Waterson
  • ANTI-MALARIAL AGENTS
    Publication number: 20150031682
    Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 29, 2015
    Inventors: Yassir Younis, Kelly Chibale, Michael John Witty, David Waterson
  • Angiotensin I-converting enzyme (ACE) inhibitors
    Patent number: 7981922
    Abstract: This invention relates to a process for synthesizing an amino acid derivative of a tripeptidomimetic, such as lisinopril. The invention also relates to a derivative of lisinopril, incorporating a amino acid moeity such as tryptophan at the P2? position.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: July 19, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-converting enzyme (ACE) inhibitors
    Patent number: 7951834
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: May 31, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-converting enzyme (ace) inhibitors
    Publication number: 20090281160
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Application
    Filed: May 29, 2006
    Publication date: November 12, 2009
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-Converting Enzyme (ACE) Inhibitors
    Publication number: 20090118351
    Abstract: This invention relates to a process for synthesising an amino acid derivative of a tripeptidomimetic, such as lisinopril. The invention also relates to a derivative of lisinopril, incorporating a amino acid moeity such as tryptophan at the P2? position.
    Type: Application
    Filed: May 29, 2006
    Publication date: May 7, 2009
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • ANTI-PARASITIC COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20070197495
    Abstract: The present invention provides a novel class of compounds that disrupt the parasitic infectious life cycle and serve as promising agents for anti-parasitic therapy.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 23, 2007
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Kelly Chibale