Patents by Inventor Kelly Fitzgerald

Kelly Fitzgerald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220111060
    Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifuinctional/multifuinctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc?RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc?RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 14, 2022
    Inventors: David A. Spiegel, Patrick McEnaney, Kelly Fitzgerald
  • Patent number: 10912836
    Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc?RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc?RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: February 9, 2021
    Assignee: YALE UNIVERSITY
    Inventors: David A. Spiegel, Patrick McEnaney, Kelly Fitzgerald
  • Publication number: 20190209696
    Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc?RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc?RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient.
    Type: Application
    Filed: November 5, 2018
    Publication date: July 11, 2019
    Inventors: David A. Spiegel, Patrick McEnaney, Kelly Fitzgerald
  • Patent number: 10117943
    Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc?RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc?RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: November 6, 2018
    Assignee: YALE UNIVERSITY
    Inventors: David A. Spiegel, Patrick McEnaney, Kelly Fitzgerald
  • Patent number: 10016412
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: July 10, 2018
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Kelly Fitzgerald
  • Publication number: 20170087148
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
    Type: Application
    Filed: December 9, 2016
    Publication date: March 30, 2017
    Inventors: David Spiegel, Kelly Fitzgerald
  • Patent number: 9556167
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: January 31, 2017
    Assignee: YALE UNIVERSITY
    Inventors: David Spiegel, Kelly Fitzgerald
  • Publication number: 20160082112
    Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc?RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc?RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient.
    Type: Application
    Filed: May 3, 2013
    Publication date: March 24, 2016
    Inventors: David A. Spiegel, Patrick McEnaney, Kelly Fitzgerald
  • Patent number: 9077756
    Abstract: Access to a mobile computing device by a connected external device is limited, based on the context of the connection. The connection of the mobile computing device to an external device is detected. An identifier of the connected external device is gleaned, and the gleaned identifier is looked-up in a database of mappings between identifiers and descriptions of specific devices. The connected external device is classified as being of a specific functional category, based on the gleaned identifier and the description of the external device from the database. The functional category describes a legitimate function to be performed by the connected external device, such as data synchronizing, media playing or battery charging. The external device is provided with a level of access to the mobile computing device based on the classified functional category.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: July 7, 2015
    Assignee: Symantec Corporation
    Inventor: Kelly FitzGerald
  • Publication number: 20150110742
    Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
    Type: Application
    Filed: May 1, 2013
    Publication date: April 23, 2015
    Applicant: Yale University
    Inventors: David Spiegel, Kelly Fitzgerald