Abstract: The present invention features, inter alia, compositions and methods for the treatment of cancer and infectious disease. The compositions include engineered proteins that specifically bind a metal chelate and may be bispecific. For example, the engineered proteins may bind (a) a target (e.g., a cellular protein) on a cancerous cell or a pathogen and (b) a metal chelate comprising DOTA, or an active variant thereof, and a metal ion such as a radionuclide. By virtue of the multiple binding sites, the engineered protein effectively delivers a metal chelate to a cell one wishes to destroy.

Abstract: A firearm bore sighting system is described for in-line muzzle loaders which include a breach plug, the bore sighting system rotating into the breach plug threads and which may include a stop to locate the bore sighting system relative to the breach.

Abstract: A firearm bore sighting system is described in which conventionally shaped cartridge body with a rim at a base end and an open forward end includes a bore formed along a cartridge axis. An optical beam emitting device is received within the bore, with potting material formed about the beam emitting device, securing the beam emitting device in a spatial relation to the cartridge axis such that an optical beam emitted from the beam emitting device is coaxial with the cartridge axis.

Abstract: A firearm bore sighting system is described in which conventionally shaped cartridge body with a rim at a base end and an open forward end includes a bore formed along a cartridge axis. An optical beam emitting device is received within the bore, with potting material formed about the beam emitting device, securing the beam emitting device in a spatial relation to the cartridge axis such that an optical beam emitted from the beam emitting device is coaxial with the cartridge axis.