Abstract: The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.

Abstract: Systems, methods, and computer-readable media are disclosed for automated server-based content delivery. In one embodiment, an example method may include determining campaign information for a content delivery campaign, the campaign information comprising a first allocation value for first content, and a second allocation value for second content, determining first observed data comprising a first user response rate for the first content and a second user response rate for the second content, determining an exponentiated gradient algorithm for the content delivery campaign, and determining a reallocation amount to reallocate a portion of the first allocation value to the second allocation value using the exponentiated gradient algorithm based at least in part on the first observed data, wherein the reallocation amount maximizes an output of the exponentiated gradient algorithm.