Abstract: The disclosure relates to novel compounds that include one or more aromatic boron-containing groups and methods of making the disclosed compounds. The present disclosure further relates to pharmaceutical compositions comprising the disclosed compounds, and their use in prevention and treatment of diseases and disorders.

Abstract: Embodiments of the present disclosure relate to sensors that can selectively bind to specific vicinal diols in the presence of other diols. These boronated vicinal diol-responsive sensor compounds can sense levels of specific vicinal diols and respond to these molecules in the body. In certain embodiments, the vicinal diol is a cis diol, for example, a hexose such as glucose. In certain embodiments the sensors are conjugated to a drug substance, and the sensors may change the biophysical characteristics, pharmacokinetics, and/or activity of the drug substance in response to the vicinal diol. The drug substance may be or include a polypeptide, such as an insulin, a human endocrine or incretin peptide, or an analogue thereof, and may contain one or more modified amino acids containing a vicinal diol-responsive sensor.

Abstract: A static inverter assembly including a housing, a heat sink connected to the housing to define an enclosed three-dimensional volume, the heat sink including at least one channel extending therethrough, the channel including a plurality of cooling fins, a cooling fan positioned relative to the channel to encourage a fluid flow through the channel, and static inverter electronics positioned in the enclosed three-dimensional volume, wherein heat generated by the static inverter electronics is dissipated by the fluid flow through the heat sink.