Patents by Inventor Kelly T. Hughes

Kelly T. Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for adjustable ribosome translation speed and methods of use
    Patent number: 11293028
    Abstract: The present invention relates to the effects of codon context and synonymous codon changes on mRNA translation and methods of increasing protein production.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: April 5, 2022
    Assignee: University of Utah Research Foundation
    Inventors: Kelly T. Hughes, Fabienne Chevance
  • Compositions and methods for peptide expression and purification using a type III secretion system
    Patent number: 10800818
    Abstract: Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 13, 2020
    Assignee: University of Utah Research Foundation
    Inventors: Kelly T. Hughes, Baldomero M. Olivera
  • COMPOSITIONS FOR ADJUSTABLE RIBOSOME TRANSLATION SPEED AND METHODS OF USE
    Publication number: 20180282738
    Abstract: The present invention relates to the effects of codon context and synonymous codon changes on mRNA translation and methods of increasing protein production.
    Type: Application
    Filed: October 3, 2016
    Publication date: October 4, 2018
    Inventors: Kelly T. HUGHES, Fabienne CHEVANCE
  • COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE III SECRETION SYSTEM
    Publication number: 20180009851
    Abstract: Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
    Type: Application
    Filed: March 15, 2017
    Publication date: January 11, 2018
    Inventors: Kelly T. HUGHES, Baldomero M. Olivera
  • Compositions and methods for peptide expression and purification using a type III secretion system
    Patent number: 9630997
    Abstract: Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: April 25, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Kelly T. Hughes, Baldomero M. Olivera
  • COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE III SECRETION SYSTEM
    Publication number: 20150225466
    Abstract: Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
    Type: Application
    Filed: May 30, 2013
    Publication date: August 13, 2015
    Applicant: University of Utah Research Foundation
    Inventors: Kelly T. Hughes, Baldomero M. Olivera
  • METHODS AND COMPOSITIONS RELATED TO BACTERIAL FLAGELLUM AND NANOTUBE FORMATION
    Publication number: 20080112982
    Abstract: Disclosed are compositions and methods relating to bacterial flagella and uses thereof.
    Type: Application
    Filed: June 12, 2007
    Publication date: May 15, 2008
    Inventor: Kelly T. Hughes