Patents by Inventor Kelly Zalocusky

Kelly Zalocusky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF TARGETING NEURONAL APOE TO TREAT A NEUROCOGNITIVE DISORDER
    Publication number: 20220348638
    Abstract: A method for reducing neuronal and synaptic degeneration or loss in a population of neuronal cells is provided as well as a method of treating an individual with a neurocognitive disorder. Aspects of the methods include modulating the level and/or activity of apolipoprotein E (apoE) in a population of neuronal cells where the modulating reduces the level and/or activity of an MHC pathway polypeptide in the population of neuronal cells.
    Type: Application
    Filed: September 24, 2020
    Publication date: November 3, 2022
    Inventors: Yadong Huang, Kelly Zalocusky
  • DOPAMINE RECEPTOR TYPE 2 SPECIFIC PROMOTER AND METHODS OF USE THEREOF
    Publication number: 20200032291
    Abstract: A nucleic acid containing a dopamine receptor type 2-specific promoter (D2SP) is provided. In certain embodiments, the nucleic acid includes a dopamine receptor type 2-specific promoter (D2SP), wherein the D2SP does not include exon 1 of a D2 receptor gene, wherein the D2SP comprises a Kozak sequence, and wherein the D2SP includes a nucleotide sequence having at least 95% sequence identity to the nucleotide sequence set forth in SEQ ID NO: 1. Also provided are expression vectors, genetically modified host cells and kits that include the subject nucleic acid.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 30, 2020
    Inventors: Karl A. Deisseroth, Charu Ramakrishnan, Kelly Zalocusky
  • Dopamine receptor type 2 specific promoter and methods of use thereof
    Patent number: 10435709
    Abstract: A nucleic acid containing a dopamine receptor type 2-specific promoter (D2SP) is provided. In certain embodiments, the nucleic acid includes a dopamine receptor type 2-specific promoter (D2SP), wherein the D2SP does not include exon 1 of a D2 receptor gene, wherein the D2SP comprises a Kozak sequence, and wherein the D2SP includes a nucleotide sequence having at least 95% sequence identity to the nucleotide sequence set forth in SEQ ID NO: 1. Also provided are expression vectors, genetically modified host cells and kits that include the subject nucleic acid.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 8, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl A. Deisseroth, Charu Ramakrishnan, Kelly Zalocusky
  • DOPAMINE RECEPTOR TYPE 2 SPECIFIC PROMOTER AND METHODS OF USE THEREOF
    Publication number: 20170327841
    Abstract: A nucleic acid containing a dopamine receptor type 2-specific promoter (D2SP) is provided. In certain embodiments, the nucleic acid includes a dopamine receptor type 2-specific promoter (D2SP), wherein the D2SP does not include exon 1 of a D2 receptor gene, wherein the D2SP comprises a Kozak sequence, and wherein the D2SP includes a nucleotide sequence having at least 95% sequence identity to the nucleotide sequence set forth in SEQ ID NO: 1. Also provided are expression vectors, genetically modified host cells and kits that include the subject nucleic acid.
    Type: Application
    Filed: December 3, 2015
    Publication date: November 16, 2017
    Inventors: Karl A. Deisseroth, Charu Ramakrishnan, Kelly Zalocusky