Abstract: The present invention relates to a composition for preventing or treating inflammatory or autoimmune skin disease. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. The present invention also provides a screening method capable of quickly and highly reliably identifying promising therapeutic candidates that are able to alleviate various autoimmune and inflammatory damages occurring in skin tissue by inhibiting the activity of skin-specific T cells.

Abstract: The present invention relates to a composition for prevention or treatment of inflammatory or autoimmune skin diseases. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. In addition, the composition of the present invention may be efficiently delivered to the stratum corneum of the skin, so that it is able to exert a lesion-specific and intensive immune control effect as a composition for topical application to the skin. Moreover, it shows little toxicity to normal skin tissue, and thus is suitable even for long-term administration for the treatment of atopic dermatitis, a chronic disease.