Abstract: Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, have been shown to exhibit anti-viral and other biological activities at non-toxic levels.

Abstract: The invention relates to the isolation, characterization and application of a bioherbicide composition characterized by its phytotoxcity towards the agricultural pest Convolvulus arvensis (field bindweed) and the aquatic weed Lemna paucicostata. The composition consists of a compound of formula I: ##STR1## wherein R.sub.1 is selected from H and OH, and R.sub.2 is selected from --CH.sub.2 OH and --COOH, salts and esters thereof, in association with an agriculturally acceptable carrier. The herbicide of this invention can be used for the control of field binweed and potentially other pest plants.

Abstract: The invention relates to a biofungicidal composition characterized by its capacity to arrest the growth and/or destroy the cell wall of pathogenic fungi, comprises a composition of a compound of the formula I ##STR1## wherein R.sub.1 is selected from the group consisting of ##STR2## and R.sub.2 is --H or --OH and mixtures thereof in association with an inert carrier, and to a method for arresting the growth and/or destroying the cell wall of pathogenic fungi by applying thereto a biofungicidal amount of the composition of a compound of formula I in association with an inert carrier.

Abstract: Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, have been shown to exhibit anti-viral and other biological acivities at non-toxic levels.

Abstract: Compounds to general formula ##STR1## in which R and R' are hydrogen or benzyl and X represents a purine on pyrimidine base group selected from isoguanine, guanine, cytosine, 5-fluorouracil, S-methyl uracil (thymine) and chloroguanine, exhibit anti-viral properties.

Abstract: Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted pyrimidine or triazine base, exhibit anti-viral activities e.g. against herpes simplex virus and cytomegalo-virus at non-toxic levels.

Abstract: 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl ]guanine either alone or in admixture with interferon is active in treatment of herpes simplex type 1 viral infections.

Abstract: The novel nucleoside analogue 9-[1-(1,3-diacetoxy-2-propoxy)-2-acetoxy]ethylguanine has the effect of stimulating the rate of growth of certain viruses, particularly influenza viruses, so that culturing virally infected cells in the presence of this compound substantially decreases the time required for diagnosis and typing of the virus, ready for administration of appropriate anti viral measures.

Abstract: Phosphorylated nucleotides for addition to nucleotide chains in the stepwise synthesis of oligonucleotides, e.g. as a polymeric support, are prepared in dioxane solvent and then lyophilized, to provide a stable, dry product ready for re-dissolving in reaction solvent. The lyophilized products are stable indefinitely and do not suffer from decreased reactivity.

Abstract: Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups and the like, and B is a base such as adenine, have been shown to exhibit anti-viral and other biological activities at non-toxic levels. Also provided are phosphate-linked dinucleotide compounds of similar structures.

Abstract: Silylated arabino-base compounds of the general formula: ##STR1## in which B represents an optionally substituted purine or pyrimidine base (cytosine, guanine, uracil, thymine or adenine) and one at least of R, R' and R" is alkylsilyl, the others being hydrogen, show activity as antiviral agents, especially in combatting herpes simplex virus. The preferred alkylsilyl group is tert. butyldimethylsilyl.