Abstract: Systems and methods for treatment of an aortic tear or dissection (such as in the thoracic aortic region) are provided. Some methods disclosed herein include inserting an endoprosthesis near an inlet flap of an aortic tear or dissection, inserting an infusion catheter near the inlet flap of the aortic tear or dissection, positioning said infusion catheter between an outer surface of the endoprosthesis and an aortic wall, expanding the endoprosthesis so that the infusion catheter is in contact with aortic tissue near the inlet flap, infusing a stabilization treatment compound through the infusion catheter, wherein the stabilization treatment compound comprises a contrast media agent, a stabilizing agent, and one or more excipients, and removing the infusion catheter.

Abstract: Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. The PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver the therapeutic solution into the sealed volume or a portion of the sealed volume The downstream balloon may be expanded by an expansion of a balloon disposed inside the downstream balloon.

Abstract: The methods, systems and devices provided herein relate to sleep-aid. Some embodiments include a vibration source and/or a sound source. In some embodiments, the vibration source and/or sound source emit vibrations and/or sounds that stimulate a subject's vagus nerve, or another nerve, to induce sleep or relaxation in the subject.

Abstract: Methods and compositions for treating post-surgery laxity of tendons or tendon repair are provided that utilize 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

Abstract: Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

Abstract: The methods, systems and devices provided herein relate to sleep-aid. Some embodiments include a vibration source and/or a sound source. In some embodiments, the vibration source and/or sound source emit vibrations and/or sounds that stimulate a subject's vagus nerve, or another nerve, to induce sleep or relaxation in the subject.

Abstract: Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

Abstract: Methods and compositions for treatments associated with endovascular grafts, dissections, peripheral aneurysms, and neuro aneurysms are provided that deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof and/or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

Abstract: Methods and compositions for treating post-surgery laxity of tendons or tendon repair are provided that utilize 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

Abstract: The methods, systems and devices provided herein relate to sleep-aid. Some embodiments include a vibration source and/or a sound source. In some embodiments, the vibration source and/or sound source emit vibrations and/or sounds that stimulate a subject's vagus nerve, or another nerve, to induce sleep or relaxation in the subject.

Abstract: Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

Abstract: Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

Abstract: The present disclosure relates to enzyme formulations and methods of using the enzyme formulations to reduce the viscosity of fluids used in hydrocarbon recovery. Some embodiments provide particles for well treatment, where the particles comprise an acidifier carrier and an enzyme co-encapsulated within a shell. The particles can, for example, allow a delayed or controlled release of the enzyme in a high temperature, high pressure environment.

Abstract: Systems and methods for accessing body tissue are disclosed. The systems and methods can include an introducer assembly for percutaneous access to a body lumen. The assembly can include a needle and an over-the-needle guidewire. The needle and the guidewire can be inserted into body tissue and the guidewire advanced into the body tissue relative to the needle. The needle can be removed after advancing the guidewire.

Abstract: The present disclosure relates to enzyme formulations and methods of using the enzyme formulations to reduce the viscosity of fluids used in hydrocarbon recovery. Some embodiments provide particles for well treatment, where the particles comprise an acidifier carrier and an enzyme co-encapsulated within a shell. The particles can, for example, allow a delayed or controlled release of the enzyme in a high temperature, high pressure environment.

Abstract: The present invention provides for treatment of ostial occlusions through placement of scaffold in a side-branch adjacent the ostium.

Abstract: Systems and methods for accessing body tissue are disclosed. The systems and methods can include an introducer assembly for percutaneous access to a body lumen. The assembly can include a needle and an over-the-needle guidewire. The needle and the guidewire can be inserted into body tissue and the guidewire advanced into the body tissue relative to the needle. The needle can be removed after advancing the guidewire.

Abstract: An infusion catheter includes a catheter body having a proximal end, a distal end, and two or more lumens extending therethrough. The infusion catheter also includes an infusion tube having a proximal end, a distal end, and one or more ports disposed therethrough. The first lumen of the catheter body is in fluid communication with the lumen of the infusion tube. A central member has a distal end connected to the distal end of the infusion tube, a proximal end, and a proximal portion slidably received in the second lumen of the catheter body. The infusion tube is disposed relative to the central member such that axial advancement of the central member relative to the catheter body radially collapses the infusion tube over the central member and axial retraction of the central member relative to the catheter body radially expands the infusion tube about the central member.

Abstract: Systems and methods for accessing body tissue are disclosed. The systems and methods can include an introducer assembly for percutaneous access to a body lumen. The assembly can include a needle and an over-the-needle guidewire. The needle and the guidewire can be inserted into body tissue and the guidewire advanced into the body tissue relative to the needle. The needle can be removed after advancing the guidewire.

Abstract: Systems and methods for accessing body tissue are disclosed. The systems and methods can include an introducer assembly for percutaneous access to a body lumen. The assembly can include a needle and an over-the-needle guidewire. The needle and the guidewire can be inserted into body tissue and the guidewire advanced into the body tissue relative to the needle. The needle can be removed after advancing the guidewire.