Patents by Inventor Kelvin S. Holdom
Kelvin S. Holdom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5840704Abstract: The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R.sup.1 when taken individually is H or OH; R and R.sup.1 when taken together represent a double bond;R.sup.2 is an alpha-branched C.sub.3 -C.sub.8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.8 cycloalkenyl or C.sub.5 -C.sub.8 cycloalkylalkyl group, any of which may be substituted by methylene or one or more C.sub.1 -C.sub.4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be substituted by one or more C.sub.1 -C.sub.4 alkyl groups or halo atoms;R.sup.3 is hydrogen or methyl;R.sup.4 is H or 4'-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy with the proviso that when R.sup.2 is alkyl it is not isopropyl or sec-butyl; when R.sup.4 is H, each of R and R.sup.1 is H, and R.sup.2 is not methyl or ethyl; and when R.sup.Type: GrantFiled: March 23, 1993Date of Patent: November 24, 1998Assignee: Pfizer Inc.Inventors: Stephen P. Gibson, Alexander C. Goudie, Kelvin S. Holdom, John D. Bu'Lock
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Patent number: 5583015Abstract: Streptomyces avermitilis lacking branched-chain amino acid transaminase activity and/or branched-chain 2-oxo acid dehydrogenase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins useful as parasiticides.Type: GrantFiled: October 14, 1994Date of Patent: December 10, 1996Assignee: Pfizer Inc.Inventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 5576199Abstract: Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin B O-methyltransferase activity, method for preparation thereof, and use thereof to produce natural and non-natural B avermectins useful as parasiticides.Type: GrantFiled: October 14, 1994Date of Patent: November 19, 1996Assignee: Pfizer Inc.Inventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 5565359Abstract: Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin B O-methyltransferase activity, method for preparation thereof, and use thereof to produce natural and non-natural B avermectins useful as parasiticides.Type: GrantFiled: May 23, 1995Date of Patent: October 15, 1996Assignee: Pfizer Inc.Inventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 5525506Abstract: Streptomyces avermitilis lacking branched-chain amino acid transaminase activity and/or branched-chain 2-oxo acid dehydrogenase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins useful as parasiticides.Type: GrantFiled: October 14, 1994Date of Patent: June 11, 1996Assignee: Pfizer Inc.Inventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 5451511Abstract: The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R.sup.1 when taken individually is H or OH; R and R.sup.1 when taken together represent a double bond;R.sup.2 is an alpha-branched C.sub.3 -C.sub.8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.8 cycloalkenyl or C.sub.5 -C.sub.8 cycloalkylalkyl group, any of which may be substituted by methylene or one or more C.sub.1 -C.sub.4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be substituted by one or more C.sub.1 -C.sub.4 alkyl groups or halo atoms;R.sup.3 is hydrogen or methyl;R.sup.4 is H or 4'-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy with the proviso that when R.sup.2 is alkyl it is not isopropyl or sec-butyl; when R.sup.4 is H, each of R and R.sup.1 is H, and R.sup.2 is not methyl or ethyl; and when R.sup.4 is H, R is H, R.sup.1 is OH, and R.sup.Type: GrantFiled: March 9, 1993Date of Patent: September 19, 1995Assignee: Pfizer Inc.Inventors: Stephen P. Gibson, Alexander C. Goudie, Kelvin S. Holdom, John D. Bu'Lock
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Patent number: 5238848Abstract: Streptomyces avermitilis lacking branched-chain amino acid transaminase activity and/or branched-chain 2-oxo acid dehydrogenase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins useful as parasiticides.Type: GrantFiled: February 27, 1991Date of Patent: August 24, 1993Assignee: Pfizer IncInventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 5234831Abstract: Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin B O-methyltransferase activity, method for preparation thereof, and use thereof to produce natural and non-natural B avermectins useful as parasiticides.Type: GrantFiled: February 26, 1991Date of Patent: August 10, 1993Assignee: Pfizer IncInventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 5089480Abstract: The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R.sup.1 when taken individually is H or OH; R and R.sup.1 when taken together represent a double bond;R.sup.2 is an alpha-branched C.sub.3 -C.sub.8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C.sub.3 -C.sub.8 cycloalkyl, C.sub.5 -C.sub.8 cycloalkenyl or C.sub.5 -C.sub.8 cycloalkylalkyl group, any of which may be substituted by methylene or one or more C.sub.1 -C.sub.4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be substituted by one or more C.sub.1 -C.sub.4 alkyl groups or halo atoms;R.sup.3 is hydrogen or methyl;R.sup.4 is H or 4'-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy with the proviso that when R.sup.2 is alkyl it is not isopropyl or sec-butyl; when R.sup.4 is H, each of R and R.sup.1 is H, and R.sup.2 is not methyl or ethyl; and when R.sup.4 is H, R is H, R.sup.1 is OH, and R.sup.Type: GrantFiled: January 11, 1988Date of Patent: February 18, 1992Assignee: Pfizer Inc.Inventors: Stephen P. Gibson, Alexander C. Goudie, Kelvin S. Holdom, John D. Bu'lock
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Patent number: 5077278Abstract: Non-natural demethylavermectins useful as parasiticides and process therefor.Type: GrantFiled: November 30, 1987Date of Patent: December 31, 1991Assignee: Pfizer Inc.Inventors: Edmund W. Hafner, Kelvin S. Holdom, S. Edward Lee
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Patent number: 4992369Abstract: A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.Type: GrantFiled: June 15, 1989Date of Patent: February 12, 1991Assignee: Pfizer Inc.Inventors: Hiroshi Maeda, Junsuke Tone, John C. Ruddock, Kelvin S. Holdom
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Patent number: 4954482Abstract: A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.Type: GrantFiled: July 20, 1989Date of Patent: September 4, 1990Assignee: Pfizer Inc.Inventors: Hiroshi Maeda, Junsuke Tone, John C. Ruddock, Kelvin S. Holdom
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Patent number: 4920215Abstract: The antibiotic of the formula: ##STR1## wherein R is ##STR2## The antibiotic is useful for the treatment of swine dysentery and for promoting growth and/or increasing the efficiency of food utilization in poultry, swine and ruminants.Type: GrantFiled: December 16, 1987Date of Patent: April 24, 1990Assignee: Pfizer Inc.Inventors: Kelvin S. Holdom, John C. Ruddock, Junsuke Tone, Hiroshi Maeda, Martin R. Jefson
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Patent number: 4740464Abstract: Aconitic acid, an unsaturated tricarboxylic acid, is obtained by fermentation of an aconitic acid-accumulating strain of Aspergillus terreus or Aspergillus itaconicus, under aerobic conditions, in a carbohydrate-containing medium, followed by isolation of the aconitic acid or a salt thereof. A preferred aconitic acid-accumulating microorganism is the strain of Aspergillus terreus which is on deposit in the Culture Collection of the Commonewealth Mycological Institute at Kew, Surrey, United Kingdom, under Accession No. CMI CC 281924.Type: GrantFiled: November 30, 1984Date of Patent: April 26, 1988Assignee: Pfizer Inc.Inventors: Kelvin S. Holdom, Norman Winskill