Patents by Inventor Keming ZHANG

Keming ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC CHIMERIC ANTIGEN RECEPTORS BINDING TO CD19 AND CD22
    Publication number: 20240082402
    Abstract: Bi-specific chimeric antigen receptors (CARs) capable of binding to both CD19 and CD22 and immune cells expressing such. Also provided herein are therapeutic uses of such immune cells (e.g., CAR-T cells) for eliminating disease cells such as cancer cells.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 14, 2024
    Applicant: Elpis Biopharmaceuticals
    Inventors: Yan CHEN, Jenna NGUYEN, Kehao ZHAO, Keming ZHANG
  • Bi-specific antigen-binding polypeptides
    Patent number: 11814441
    Abstract: The present invention provides antigen-binding polypeptides, including bi-specific antigen-binding polypeptides, that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease, including cancer, are also encompassed by the invention.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: November 14, 2023
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Richard W. Wagner, Keming Zhang, Pascale Richalet
  • BI-SPECIFIC ANTIGEN-BINDING POLYPEPTIDES
    Publication number: 20190248918
    Abstract: The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.
    Type: Application
    Filed: January 22, 2019
    Publication date: August 15, 2019
    Inventors: Yan CHEN, Richard W. WAGNER, Keming ZHANG, Pascale RICHALET
  • Bi-specific antigen-binding polypeptides
    Patent number: 10202462
    Abstract: The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 12, 2019
    Assignee: X-BODY, Inc.
    Inventors: Yan Chen, Richard W. Wagner, Keming Zhang, Pascale Richalet
  • BI-SPECIFIC ANTIGEN-BINDING POLYPEPTIDES
    Publication number: 20150299335
    Abstract: The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.
    Type: Application
    Filed: March 20, 2015
    Publication date: October 22, 2015
    Inventors: Yan CHEN, Richard W. WAGNER, Keming ZHANG, Pascale RICHALET