Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: Methods and apparatus are provided for a shock attenuation device configured to operate between a structure and a mass that is supported by and moveable relative to the structure in a guided manner along a stroking direction. In one embodiment, a notch load portion is configured to provide a resisting force to relative displacement of the supported mass over a first stage stroking distance according to a predefined load profile that includes a spike load peaking at a first threshold load value at the onset of relative displacement, and a substantially constant notch load for a remainder of the first stage stroking distance. A constant load portion arranged serially with the notch load portion is configured to provide a substantially constant resisting force to displacement of the supported mass at a second threshold load value over a second stage stroking distance, wherein the second threshold load value is higher than the first threshold load value.

Abstract: Methods and apparatus are provided for a shock absorbing vehicle seating system. In one embodiment the seating system includes a seat moveably attached to a vehicle by a seat guide apparatus configured to constrain seat movement to a stroking direction. The system further includes a spring damper with opposed first and second ends, configured to compress along a longitudinal axis extending through the ends in response to an external compressive load, and an energy attenuating component with a deformable portion disposed between a first end and a second end thereof. The spring damper and energy attenuating component are arranged serially with respect to one another, and together form a seat supporting assembly disposed between the seat and the vehicle. The energy attenuating component is configured to deform in a predictable manner in response to a shock load that reaches a predefined threshold value, allowing the seat to stroke in the stroking direction as the energy attenuating component absorbs energy.

Abstract: Methods and apparatus are provided for a shock attenuation device configured for use in conjunction with a body movably mounted to a structure along a stroking direction to attenuate shock loads associated with a high energy impact event on the structure. The device includes an elongated metal frame with left and right sides symmetrically disposed about a longitudinal slot extending from proximate a first end of the frame to a second end. The frame is mountable to one of the body and structure in an orientation causing the longitudinal slot to align with the stroking direction. A mandrel mountable to the other one of the body and structure is positioned in the frame at one end of the slot. The mandrel has width and length dimensions measured in the plane of the frame, wherein a maximum width of the mandrel is greater than a width of the slot.

Abstract: Methods and apparatus are provided for a self adjusting energy attenuating vehicle seating system configured to automatically compensate for variations in the weight of seated occupants. A seat is mounted in a vehicle and configured to stroke in a downward direction, generally toward a floor of the vehicle, with an adjustable energy attenuating device disposed in a load path between the seat and a rigid structural portion of the vehicle. A signal processor removes variations in a seat weight signal attributable to vehicle or occupant motion, and outputs an energy attenuator adjustment signal corresponding to the weight of a seated occupant. The system may further include an actuator configured to receive the energy attenuator adjustment signal and adjust a load setting feature of the energy attenuating device accordingly.

Abstract: Methods and apparatus are provided for a vehicle electronic power system. In one exemplary embodiment an energy harvesting device is configured to generate electricity in response to vibration of the vehicle occurring during normal vehicle operation. The energy harvesting device may be tuned to a frequency that falls within a peak energy region in a vibration profile of the vehicle. The power system may further include a charging circuit connecting the energy harvesting device to a rechargeable battery provides electrical power to an electro-mechanical vehicle component or system.

Abstract: Methods and apparatus are provided for a mounting system for attaching a container to a vehicle adapted to resist loads imparted by the container to the mounting system in sequential stages. In one exemplary mounting system a first spring is configured to elastically compress when subjected to an initiation load that exceeds a load imparted to the first spring by the container under static conditions. The first spring may have a useable load range from the initiation load to a maximum load at which the first spring is fully bottomed out. A first deformable member is disposed serially with respect to the first spring, and configured to remain substantially un-deformed until subjected to a first deformation threshold load that equals or exceeds the maximum load at which the first spring is fully bottomed out.

Abstract: Methods and apparatus are provided for a mounting system for attaching a container to a vehicle adapted to resist loads imparted by the container to the mounting system in sequential stages. In one exemplary mounting system a first spring is configured to elastically compress when subjected to an initiation load that exceeds a load imparted to the first spring by the container under static conditions. The first spring may have a useable load range from the initiation load to a maximum load at which the first spring is fully bottomed out. A first deformable member is disposed serially with respect to the first spring, and configured to remain substantially un-deformed until subjected to a first deformation threshold load that equals or exceeds the maximum load at which the first spring is fully bottomed out.

Abstract: Designs and methods are provided for a hydraulic strut and control system suitable for energy attenuation applications such as vehicle seating system. In one exemplary embodiment the hydraulic strut includes a main cylinder having a first closed end, a second end with an opening. A main piston slidably disposed in the main cylinder divides it into a first fluid chamber between the main piston and the first end of the main cylinder, and a second fluid chamber between the main piston and the second end of the main cylinder. At least one fixed orifice through the piston provides fluid communication between the first and second fluid chambers. An integral flow control valve is adapted to vary the flow area of the at least one orifice through the piston. The flow control valve is operatively connected to a high speed actuator responsive to an electrical control signal.

Abstract: Methods and apparatus are provided for an actively variable shock absorbing system for actively controlling the load response characteristics of a shock absorbing strut. In one embodiment the shock absorbing system comprises a controllable valve adapted for actively varying a load response characteristic of the shock absorbing strut. The shock absorbing system further comprises an electronic control system comprising an input for receiving a signal from a sensor, an algorithm adapted to determine an optimal position for the controllable valve in view of the sensor signal, and an output for sending a control signal to the controllable valve to place the valve in the optimal position.

Abstract: Designs and methods are provided for a multi-layer panel capable of mitigating the transmission of a high energy impulse to the hull of the vehicle. In one exemplary embodiment, the blast panel comprises a first penetration resistant layer on the side facing away from the vehicle, a first core made of a crushable structural material between the first penetration resistant layer and the vehicle, and a shock dissipation layer disposed between the first penetration resistant layer and the first core.

Abstract: Methods and apparatus are provided for a safety restraint system for use inside a vehicle compartment by a mobile occupant or crew member. In one preferred embodiment the safety restraint system comprises an upper trolley and track system connected to the ceiling of the vehicle compartment, a lower trolley and track system connected to the floor of the compartment, and a lockable inertia reel with an extensible strap pivotally attached to the upper trolley. The restraint system further comprises an upper tether connected at an upper end to the end of the inertia reel extensible strap, and at the other end to a harness worn by the occupant. The system may further include a lower tether connected at one end to the lower trolley, and connectable at the other end to the occupant's harness.

Abstract: Methods and apparatus are provided for attaching a rigid armor plate to the exterior of a vehicle hull. The exemplary system includes an armor attachment point on the vehicle hull, a hole through the armor plate in alignment with the armor attachment point, and a fastener extending through the hole connecting the armor plate to the vehicle hull. The hole through the armor plate may be larger than the fastener, defining a circumferential gap between the fastener and armor plate. The fastener may comprise a material with an energy absorption capability in excess of 2,000 ksi, and more preferably in excess of 5,000 ksi.

Abstract: A leg assembly for mounting passenger seats in transport vehicles especially configured to absorb energy, in the event of a survivable crash or other sudden deceleration. The seat legs deform in a controlled manner to prevent loads at its floor attachment points from exceeding the magnitude of allowable floor strength. The leg assembly includes a base member whose forward and rear ends attach to the floor, and a V-leg whose lower vertex pivots about an axis passing through the front of the base member in the event of a forward crash. The V-leg has a vertical member and a diagonal member. A load-limiting strut connects the rear end of the base member to an intermediate area on the diagonal member of the V-leg. A tension link connects the intermediate area of the V-leg and to the upper end of the vertical member of the V-leg.

Abstract: A fiber optic sensor for measuring strain on and within structures. The sensor includes an optical fiber, two reflective markers, and two thin layers of carrier material. The optical fiber is looped multiple times within the two thin layers of the carrier material. The optical signal circulates multiple times through the sensing region, as it is travels through the multiple loops of optical fiber within the carrier layers. The fiber optic sensor can be embedded within a structure, as that structure is being fabricated, or it can be attached onto a preexisting structure. An optical signal generated from a source such as a laser is input into one end of the optical fiber. The signal is reflected at reflective markers at predetermined positions in the optical fiber. The time delay of the signals received back is then analyzed to calculate the strain in the structure.