Patents by Inventor Ken Chien

Ken Chien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA SEQUENCING BY SYNTHESIS USING MODIFIED NUCLEOTIDES AND NANOPORE DETECTION
    Publication number: 20250066848
    Abstract: This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
    Type: Application
    Filed: November 12, 2024
    Publication date: February 27, 2025
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Shiv Kumar, Zengmin Li, Chuanjuan Tao, Minchen Chien, James J. Russo, Sergey Kalachikov, Ken Shepard, Jacob Karl Rosenstein
  • Methods of identifying small molecules for renewals, survival and migration of cardiac progenitors
    Patent number: 8323909
    Abstract: The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3? inhibitor.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: December 4, 2012
    Assignee: The Regents of the University of California
    Inventors: Sylvia Evans, Ju Chen, Lizhu Lin, Ken Chien, Yibing Qyang, Alessandra Moretti, Karl Laugwitz
  • METHODS OF IDENTIFYING SMALL MOLECULES FOR RENEWALS, SURVIVAL AND MIGRATION OF CARDIAC PROGENITORS
    Publication number: 20100261196
    Abstract: The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3? inhibitor.
    Type: Application
    Filed: April 29, 2010
    Publication date: October 14, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sylvia Evans, Ju Chen, Lizhu Lin, Ken Chien, Yibing Qyang, Alessandra Moretti, Karl Laugwitz
  • Methods of identifying small molecules for renewal, survival and migration of cardiac progenitors
    Publication number: 20080108090
    Abstract: The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3? inhibitor.
    Type: Application
    Filed: May 2, 2007
    Publication date: May 8, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sylvia Evans, Ju Chen, Lizhu Lin, Ken Chien, Yibing Qyang, Alessandra Moretti, Karl Laugwitz