Patents by Inventor Ken-ichi Kusakabe

Ken-ichi Kusakabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210261569
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins.
    Type: Application
    Filed: July 4, 2019
    Publication date: August 26, 2021
    Inventors: Syuhei YOSHIDA, Genta TADANO, Toru YAMADA, Takuya OGUMA, Ken-ichi KUSAKABE, Frederik ROMBOUTS, Antonio MISALE
  • Publication number: 20210238194
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ßproduction, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ßproteins. A compound of Formula (I) wherein R3 is each independently alkyl optionally substituted with halogen, cyano, alkyloxy, haloalkyloxy or non-aromatic carbocyclyl, or the like; t is integer from 0 to 3; R5 is a hydrogen atom or halogen; R6 is selected from the group consisting of a hydrogen atom, halogen, and substituted or unsubstituted alkyl; ring B is a substituted or unsubstituted pyrazine or the like; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 5, 2021
    Inventors: Genta TADANO, Shinji SUZUKI, Ken-ichi KUSAKABE
  • Patent number: 9758513
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins. A compound of the formula (I): wherein X is —C(R3a)(R3b)—, —C(R3a)(R3b)—C(R3c)(R3d)— or —C(R3a)?C(R3c)—, R1 is substituted or unsubstituted alkyl or the like, R2a, R2b, R3a, R3b, R3c and R3d are each independently hydrogen, halogen or the like, R4 is hydrogen or halogen, Ring B is substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: September 12, 2017
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Ken-ichi Kusakabe, Syuhei Yoshida, Kenji Nakahara, Tsuyoshi Hasegawa, Genta Tadano, Kouki Fuchino
  • Publication number: 20170073337
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent, for diseases induced by production, secretion and/or deposition of amyloid ? proteins. A compound of the formula (I) wherein X is —S— or —O—, R3a is alkyl, haloalkyl or the like, R2a is H, halogen, alkyloxy, haloalkyloxy or the like, R2b is H or the like, R3b is H or alkyl, ring A and ring B is each independently a substituted or unsubstituted aromatic carbocycle, a substituted or unsubstituted aromatic heterocycle or the like, and R1 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 10, 2015
    Publication date: March 16, 2017
    Inventors: Ken-ichi KUSAKABE, Genta TADANO, Kazuo KOMANO, Kouki FUCHINO, Kenji NAKAHARA
  • Publication number: 20170008881
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins. A compound of the formula (I): wherein X is —C(R3a)(R3b)—, —C(R3a)(R3b)—C(R3c)(R3d)— or —C(R3a)?C(R3c)—, R1 is substituted or unsubstituted alkyl or the like, R2a, R2b, R3a, R3b, R3c and R3d are each independently hydrogen, halogen or the like, R4 is hydrogen or halogen, Ring B is substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 21, 2016
    Publication date: January 12, 2017
    Inventors: Ken-ichi KUSAKABE, Syuhei YOSHIDA, Kenji Nakahara, Tsuyoshi HASEGAWA, Genta TADANO, Kouki FUCHINO
  • Patent number: 9540359
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins. A compound of the formula (I): wherein X is —C(R3a)(R3b)—, —C(R3a)(R3b)—C(R3c)(R3d)— or —C(R3a)?C(R3c)—, R1 is substituted or unsubstituted alkyl or the like, R2a, R2b, R3a, R3b, R3c and R3d are each independently hydrogen, halogen or the like, R4 is hydrogen or halogen, Ring B is substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: January 10, 2017
    Assignee: Shionogi & Co., Ltd.
    Inventors: Ken-ichi Kusakabe, Syuhei Yoshida, Kenji Nakahara, Tsuyoshi Hasegawa, Genta Tadano, Kouki Fuchino
  • Publication number: 20150266865
    Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins. A compound of the formula (I): wherein X is —C(R3a)(R3b)—, —C(R3a)(R3b)—C(R3c)(R3d)— or —C(R3a)?C(R3c)—, R1 is substituted or unsubstituted alkyl or the like, R2a, R2b, R3a, R3b, R3c and R3d are each independently hydrogen, halogen or the like, R4 is hydrogen or halogen, Ring B is substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 23, 2013
    Publication date: September 24, 2015
    Inventors: Ken-ichi Kusakabe, Syuhei Yoshida, Kenji Nakahara, Tsuyoshi Hasegawa, Genta Tadano, Kouki Fuchino
  • Patent number: 8883779
    Abstract: The present invention provides a compound of formula (I): wherein —X? is —CR7? or —N?, ring B is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, R1 is substituted or unsubstituted alkyl or the like, R2 a and R2 b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R3 and R4 are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, R5 is hydrogen, substituted or unsubstituted alkyl or the like, each R6 is independently halogen, hydroxy, substituted or unsubstituted alkyl or the like, R7 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: November 11, 2014
    Assignee: Shinogi & Co., Ltd.
    Inventors: Moriyasu Masui, Yasunori Mitsuoka, Syuhei Yoshida, Ken-ichi Kusakabe, Naohiro Onodera, Noriyuki Kurose
  • Publication number: 20140235626
    Abstract: The present invention provides a compound of formula (I): wherein ring B is substituted or unsubstituted carbocycle or heterocycle, R1 is substituted or unsubstituted alkyl or the like, R2a and R2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R3, R4a and R4b are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, a dashed line represents a presence or absence of a bond, R5 is hydrogen, substituted or unsubstituted alkyl or the like, R6 is halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 21, 2014
    Applicant: SHIONOGI & CO., LTD.
    Inventors: Yukio Tada, Ken-ichi Kusakabe, Genta Taadano
  • Publication number: 20140051691
    Abstract: The present invention provides a compound of formula (I): wherein —X? is —CR7? or —N?, ring B is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, R1 is substituted or unsubstituted alkyl or the like, R2 a and R2 b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R3 and R4 are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, R5 is hydrogen, substituted or unsubstituted alkyl or the like, each R6 is independently halogen, hydroxy, substituted or unsubstituted alkyl or the like, R7 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid ? production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ? proteins.
    Type: Application
    Filed: April 25, 2012
    Publication date: February 20, 2014
    Applicant: SHIONOGI & CO., LTD.
    Inventors: Moriyasu Masui, Yasunori Mitsuoka, Syuhei Yoshida, Ken-ichi Kusakabe, Naohiro Onodera, Noriyuki Kurose
  • Publication number: 20120059162
    Abstract: Provided are a compound represented by general formula (1) and having a TTK inhibitory action and a medicine containing the compound. In formula (1), (X, Y, V, W) is (—N?, ?CR1—, ?N—, —CR7?), (—CR2?, ?N—, ?N—, —CR7?), etc.; A is an (un)substituted aromatic hydrocarbon ring, etc.; L is a single bond, —C(?O)—NRA—, etc.; Z is a group represented by the formula —NR3R4 or a group represented by the formula —OR5; R1 to R3, R6, and R7 each is a hydrogen atom, etc.; R4 and R5 each is an (un)substituted alkyl, etc.; and R8 is an (un)substituted cycloalkyl, etc.
    Type: Application
    Filed: July 27, 2011
    Publication date: March 8, 2012
    Applicant: Oncotherapy Science, Inc.
    Inventors: Ken-ichi Kusakabe, Hiroshi Yoshida, Kohei Nozu, Hiroshi Hashizume, Genta Tadano, Jun Sato, Yuusuke Tamura, Yasunori Mitsuoka