Abstract: A method of properly aligning a sliding side door on a vehicle includes first preparing a prototype vehicle and determining how far out of alignment the door is to the body of the prototype vehicle. This amount of misalignment is then used to adjust the attachment position of an anchor plate to a sliding side door of the vehicle, so that the anchor plate is attached at a desired position to the production vehicle, which causes there to be no misalignment between the sliding side door and the body of the production vehicle. A jig is used to hold the anchor plate at the desired location while welding the anchor plate to the door. A roller assembly is then attached to the anchor plate and to a rail on a body of the vehicle.

Abstract: Provided is a drug useful for photoimmunotherapy. Specifically, provided is a conjugate including an antibody molecule, a particle having an average particle diameter of 100 nm or less, and a photosensitive portion. In the conjugate, the particle having an average particle diameter of 100 nm or less is linked to the antibody molecule, and at least one of the antibody molecule or the particle is bound to the photosensitive portion. The photosensitive portion is a portion showing increase of hydrophobicity when irradiated with a light beam having a wavelength of from 500 nm to 900 nm or a portion containing a phthalocyanine skeleton.

Abstract: A laser processing machine includes a guide member with which a laser head is engaged so as to be movable to one side in a conveying direction, a moving device configured to move the laser head along the guide member, a counterweight which is movably engaged to the other side of the guide member in the conveying direction and moves along the guide member in a direction opposite to a moving direction of the laser head in conjunction with the laser head moved by the moving device, and a control device which controls the moving device to move the counterweight to a position facing the grease feeding device and to perform grease feeding to an engaged portion between the counterweight and the guide member.

Abstract: A laser processing machine includes a guide member with which a laser head is engaged so as to be movable to one side in a conveying direction, a moving device configured to move the laser head along the guide member, a counterweight which is movably engaged to the other side of the guide member in the conveying direction and moves along the guide member in a direction opposite to a moving direction of the laser head in conjunction with the laser head moved by the moving device, and a control device which controls the moving device to move the counterweight to a position facing the grease feeding device and to perform grease feeding to an engaged portion between the counterweight and the guide member.

Abstract: An object is to provide an antibody capable of specifically recognizing a human NRG1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human NRG1-? protein or an antibody capable of binding to a region at positions 213 to 239 of a human NRG1-?1 protein was successfully obtained. Further, it was also found that these antibodies had an activity of suppressing cleavage of the NRG1 protein, an activity of suppressing phosphorylation of an ErbB3 protein in a cancer cell, and an activity of suppressing in vivo tumor proliferation.

Abstract: An object is to provide an antibody capable of specifically recognizing a human NRG1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human NRG1-? protein or an antibody capable of binding to a region at positions 213 to 239 of a human NRG1-?1 protein was successfully obtained. Further, it was also found that these antibodies had an activity of suppressing cleavage of the NRG1 protein, an activity of suppressing phosphorylation of an ErbB3 protein in a cancer cell, and an activity of suppressing in vivo tumor proliferation.

Abstract: An object is to provide an antibody capable of specifically recognizing a human NRG1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human NRG1-? protein or an antibody capable of binding to a region at positions 213 to 239 of a human NRG1-?1 protein was successfully obtained. Further, it was also found that these antibodies had an activity of suppressing cleavage of the NRG1 protein, an activity of suppressing phosphorylation of an ErbB3 protein in a cancer cell, and an activity of suppressing in vivo tumor proliferation.

Abstract: Two types of antibodies (35-1 antibody and 292 antibody) capable of binding to phenylalanine at position 115, isoleucine at position 117, glycine at position 140, glutamic acid at position 141, and arginine at position 142 of a human HB-EGF protein were successfully obtained. Then, it was also found that these antibodies had an activity of suppressing cleavage of the human HB-EGF protein, and an activity of suppressing EGFR phosphorylation that would occur when the human HB-EGF bound to the EGFR. Further, determined were amino acid sequences of light chain and heavy chain variable regions of these antibodies and sequences of CDRs of each of the variable regions.

Abstract: A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.

Abstract: From PBMCs of patients infected with H1N1pdm, three human monoclonal antibodies have been obtained which are capable of binding to an epitope present at residues 40 to 58 in an HA2 region of a hemagglutinin protein derived from H1N1pdm. Further, these antibodies have been found to also have a neutralization activity against subtype H1 and subtype H5 of group 1 influenza A viruses. On the other hand, the three antibodies have also been found to exhibit neither a binding ability nor a neutralization activity against subtype H2 which belongs to the group 1, but in the HA2 region derived from H1N1pdm of which the amino acid at residue 45 is substituted with phenylalanine and the amino acid at residue 47 is substituted with glycine.

Abstract: A data processor capable of preventing a system from starting up improperly due to incomplete program updating. The data processor receives, by way of an external interface, a program which is sent by communicating medium such as a broadcast wave or a telephone network from an external device and stores the received program into a memory B which is different from a memory A storing a program for the system when a version of the received program is newer than that of a program currently executed by the data processor, thereby starting up an MPU at the next time with the program stored in the memory B.

Abstract: Two types of antibodies (35-1 antibody and 292 antibody) capable of binding to phenylalanine at position 115, isoleucine at position 117, glycine at position 140, glutamic acid at position 141, and arginine at position 142 of a human HB-EGF protein were successfully obtained. Then, it was also found that these antibodies had an activity of suppressing cleavage of the human HB-EGF protein, and an activity of suppressing EGFR phosphorylation that would occur when the human HB-EGF bound to the EGFR. Further, determined were amino acid sequences of light chain and heavy chain variable regions of these antibodies and sequences of CDRs of each of the variable regions.

Abstract: An object is to provide an antibody capable of specifically recognizing a human NRG1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human NRG1-? protein or an antibody capable of binding to a region at positions 213 to 239 of a human NRG1-?1 protein was successfully obtained. Further, it was also found that these antibodies had an activity of suppressing cleavage of the NRG1 protein, an activity of suppressing phosphorylation of an ErbB3 protein in a cancer cell, and an activity of suppressing in vivo tumor proliferation.

Abstract: A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.

Abstract: A fastening device includes a rotational drive portion that rotationally drives a socket, an advance/retract drive portion that causes this socket to advance or retract along a rotational axis thereof, a magazine that retains a plurality of heads that retain bolts, and a switching portion that moves this magazine to selectively position one of a plurality of heads ahead and on the rotational axis of the socket. One of the heads is selected and positioned on the rotational axis of the socket by the switching portion, then the socket is advanced by the advance/retract drive portion and the head thus selected is retained by the socket, then the socket is advanced further by the advance/retract drive portion and the head to detach is detached from the magazine, and then the head is rotated by driving the rotational drive portion, thereby fastening a bolt retained in the head.

Abstract: A vehicle wheel alignment measuring method and apparatus capable of measuring wheel alignment of a vehicle body with high accuracy without wheels mounted in an assembly line. A dummy wheel (10) is mounted on a wheel mounting portion (6) on which a wheel is not mounted. Subsequently, with a vehicle body supported, a wheel mounting portion elevating means (8) elevates the wheel mounting portion (6) via the dummy wheel (10). Thereafter, an alignment measuring means (9) measures wheel alignment for the wheel mounting portion (6) on which the dummy wheel (10) is mounted.

Abstract: A fastening device includes a rotational drive portion that rotationally drives a socket, an advance/retract drive portion that causes this socket to advance or retract along a rotational axis thereof, a magazine that retains a plurality of heads that retain bolts, and a switching portion that moves this magazine to selectively position one of a plurality of heads ahead and on the rotational axis of the socket. One of the heads is selected and positioned on the rotational axis of the socket by the switching portion, then the socket is advanced by the advance/retract drive portion and the head thus selected is retained by the socket, then the socket is advanced further by the advance/retract drive portion and the head to detach is detached from the magazine, and then the head is rotated by driving the rotational drive portion, thereby fastening a bolt retained in the head.

Abstract: There is provided an image processing apparatus for temporarily stopping reproduction of an accumulation image automatically when a display mode for displaying a broadcast image (image obtained from a broadcast wave) and the accumulation image (image obtained from a storage medium) is switched to a display mode for displaying only the broadcast image, and automatically resuming the reproduction of the accumulation image when the display mode for displaying only the broadcast image is switched to the display mode for displaying the broadcast image and the accumulation image.

Abstract: An information processor enabling a digital broadcast to be viewed at a child device at a low cost, a TV system and a program are provided. Video decoders are corrected to the post-stage of demultiplexers, respectively, and video data of MPEG divided by the demultiplexers is decoded by the video decoders. At this time, the video data of MPEG is converted into a display format of a base band in a raster scan form. A common memory having a capacity equivalent to at least one displayed image, and a memory controller controlling the operation of the common memory are further provided. Three write video data output from resolution converters is stored in the common memory under control by the memory controller.

Abstract: A vehicle wheel alignment measuring method and apparatus capable of measuring wheel alignment of a vehicle body with high accuracy without wheels mounted in an assembly line. A dummy wheel (10) is mounted on a wheel mounting portion (6) on which a wheel is not mounted. Subsequently, with a vehicle body supported, a wheel mounting portion elevating means (8) elevates the wheel mounting portion (6) via the dummy wheel (10). Thereafter, an alignment measuring means (9) measures wheel alignment for the wheel mounting portion (6) on which the dummy wheel (10) is mounted.