Publication number: 20250092064
Abstract: The present invention aims to provide a medicament capable of treating and/or preventing diseases associated with oxidative stress by inhibiting the protein-protein interaction between Keap1 and Nrf2 and activating Nrf2. The present invention relates to a compound represented by the following formula (1): wherein each symbol is as described in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. In addition, the present invention also relates to a medicament containing the aforementioned compound, for the prophylaxis and/or treatment of diseases involving oxidative stress selected from the group consisting of chronic kidney disease, non-alcoholic steatohepatitis, chronic obstructive pulmonary disease, radiation skin disorder, radiation mucosal disorder, cardiac failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma.
Type:
Application
Filed:
October 25, 2024
Publication date:
March 20, 2025
Applicants:
DAIICHI SANKYO COMPANY, LIMITED, KYOTO PHARMACEUTICAL INDUSTRIES, LTD.
Inventors:
Yoshihiro OGURA, Rieko TAKANO, Junya KAWAI, Teppei FUJIMOTO, Masaharu INUI, Masafumi OFUKU, Masaki MIYAZAKI, Masaya FUJII, Ken ISHII, Wakana YOKOZEKI, Kazuya OTAKE, Shunsuke TAKASHIMA, Masafumi ANDO