Patents by Inventor Ken Kent

Ken Kent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotides and their analogs capable of passive cell membrane permeation
    Patent number: 5763208
    Abstract: Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water of at least 0.001 .mu.g/mL. In preferred embodiments, either at least 80% of the internucleotide linkages are non-ionic, or at least 80% of the bases contain lipophilic hydrocarbyl substitutions, or a combination of these sums to 80%. These oligonucleotides may be conjugated to label and used to visualize cells.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: June 9, 1998
    Assignee: Gilead Sciences, Inc.
    Inventors: Norbert Bischofberger, Ken Kent, Rick Wagner, Chris Buhr, Kuei-Ying Lin
  • Oligonucleotide analogs capable of passive cell membrane permeation
    Patent number: 5633360
    Abstract: Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water of at least 0.001 .mu.g/mL. In preferred embodiments, either at least 80% of the internucleotide linkages are non-ionic, or at least 80% of the bases contain lipophilic hydrocarbyl substitutions, or a combination of these sums to 80%. These oligonucleotides may be conjugated to label and used to visualize cells.
    Type: Grant
    Filed: April 14, 1992
    Date of Patent: May 27, 1997
    Assignee: Gilead Sciences, Inc.
    Inventors: Norbert Bischofberger, Ken Kent, Rick Wagner, Chris Buhr, Kuei-Ying Lin