Abstract: An information processing system includes: a sample data acquisition unit that acquires, for each sample, sample data in which a first cluster and a second cluster are associated with each other, the first cluster including a plurality of sets of a biological element detected from the sample and a biological element quantity indicating a quantity of the biological element, the second cluster including a plurality of sets of a morpheme regarding text describing an environment in which the sample is present and an appearance frequency of the morpheme; and a generation unit that analyzes a plurality of pieces of the sample data with the biological element quantity and the appearance frequency as parameters and generates information indicating a relationship between the environment and the first cluster.