Abstract: [Problem] To provide a signal enhancer that enhances a signal based on reaction between an ?1-6 fucose sugar chain and an ?1-6 fucose specific lectin bound thereto, a method for using the same, and use of the same. [Solution] A signal enhancer enhances a signal based on reaction between an ?1-6 fucose sugar chain and an ?1-6 fucose specific lectin bounded thereto, and is characterized by having, as an active ingredient, at least one selected from the group consisting of urea and thiourea. The final concentration of the urea is preferably 1-9 M and the final concentration of the thiourea is 0.1-1.5 M. Since the signal enhancer allows accurate measurement of an ?1-6 fucose sugar chain, the signal enhancer is greatly useful in detection and determination of a disease related to an ?1-6 fucose sugar chain and in academic study of an ?1-6 fucose sugar chain.

Abstract: To provide a method of accurately detecting pathological haptoglobin using a lectin having strong affinity and high specificity for fucose. The method of the present invention for detecting pancreatic cancer is characterized in that a fucose ?1?6 specific lectin is allowed to act on pathological haptoglobin contained in a sample obtained from a living body, said lectin: (1) being extractede from basidiomycetes, (2) having a molecular weight of 4,000 to 40,000 as determined by the SDS polyacrylamide gel electrophoresis, and (3) having affinity for a fucose ?1?6 sugar chain with a binding constant of 1.0×104 M?1 or more at 25° C.

Abstract: To provide a method of accurately detecting pathological haptoglobin using a lectin having strong affinity and high specificity for fucose. The method of the present invention for detecting pancreatic cancer is characterized in that a fucose ?1?6 specific lectin is allowed to act on pathological haptoglobin contained in a sample obtained from a living body, said lectin: (1) being extractede from basidiomycetes, (2) having a molecular weight of 4,000 to 40,000 as determined by the SDS polyacrylamide gel electrophoresis, and (3) having affinity for a fucose ?1?6 sugar chain with a binding constant of 1.0×104 M?1 or more at 25° C.