Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: An apparatus and method of communicating between devices coupled to two networks. The first network comprises a terminal, containing an Ethernet interface, communication medium and an Ethernet interface contained in a concentrator. The second network comprises an Asynchronous Transfer Mode (ATM) interface contained in a switch, a communication medium and other components of an ATM network. Terminals transmit packets to other devices by: transmitting a packet to the concentrator, the concentrator segments the packet's information into ATM cells, and transmits the cells over the ATM network. The Terminals receive packets from other devices by: the ATM network transmitting cells to a concentrator, the cells being reassembled into Ethernet packets, then the packets being transmitted to the appropriate terminal.