Abstract: A control apparatus for an internal combustion engine including an intake adjustment part configured to adjust an intake air amount sucked into the internal combustion engine, and an electronic control unit including a microprocessor and a memory connected to the microprocessor. The microprocessor is configured to perform acquiring information on a catalyst temperature in an exhaust gas purification device provided in an exhaust passage of the internal combustion engine, controlling the intake adjustment part in accordance with a load, and the controlling including restricting the intake air amount in accordance with the catalyst temperature so as to start a restriction on the intake air amount earlier as a degree of increase in the catalyst temperature becomes greater.

Abstract: A catalyst temperature estimation apparatus estimating a catalyst temperature of an exhaust gas purification device, the exhaust gas purification device being disposed in an exhaust passage of an internal combustion engine. The internal combustion engine includes an injector injecting a fuel and having a function of a fuel cut configured to shut off a fuel injection from the injector while a vehicle is traveling. The catalyst temperature estimation apparatus includes a microprocessor, and the microprocessor is configured to perform acquiring a parameter representing an operation state of the internal combustion engine, and obtaining an estimated value of the catalyst temperature based on the parameter, wherein the obtaining includes maintaining the estimated value at a start of the fuel cut until the operation state after the fuel cut becomes a predetermined operation state when the fuel cut is executed.

Abstract: An air flow rate detection device includes a signal acquisition unit that acquires sampling values output from an air flow meter provided in an intake pipe of an internal combustion engine, an air flow rate waveform acquisition unit that acquires an air flow rate waveform indicating an air flow rate in the intake pipe, based on detected air flow rates converted from the sampling values acquired by the signal acquisition unit, an approximate waveform calculation unit that calculates an approximate waveform that is a sine wave approximating a partial waveform that is a part of the air flow rate waveform, and an air flow rate calculation unit that calculates the air flow rate based on the approximate waveform.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

Abstract: Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

Abstract: Provided is a production method of a polypeptide in which expressing a polypeptide as a tagged polypeptide is included, the method including expressing the tagged polypeptide from a nucleic acid containing a base sequence encoding a tag consisting of an amino acid sequence set forth in SEQ ID NO: 1, which is arranged immediately after a start codon, and a base sequence encoding a polypeptide that is arranged in-frame downstream of the base sequence encoding the tag, SEQ ID NO: 1: Val-Lys-Lys-(Xaa)n. (Xaa)n is a chain of n pieces of any amino acids, where n is an integer of 1 to 8, and the amino acids constituting (Xaa)n may be one type of amino acid or two or more types of amino acids.

Abstract: Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: In the present invention, a clogging rate is calculated using a first flow rate function when the degree of clogging of the throttle valve is in the reference state and a second flow rate function estimated based on the intake air volume. For each predetermined period, sample points, which are combinations of the second flow rate function and throttle valve position, are obtained, and the learning points are calculated by averaging a plurality of sample points for each predetermined position range. Based on the plurality of learning points, coefficients a to c of the approximate function of the second flow rate function characteristic are calculated by the least-squares method, and the clogging rate is calculated based on the second flow rate function characteristic and the first flow rate function approximated by the approximate function using the coefficients a to c.

Abstract: In the present invention, a clogging rate is calculated using a first flow rate function when the degree of clogging of the throttle valve is in the reference state and a second flow rate function estimated based on the intake air volume. For each predetermined period, sample points, which are combinations of the second flow rate function and throttle valve position, are obtained, and the learning points are calculated by averaging a plurality of sample points for each predetermined position range. Based on the plurality of learning points, coefficients a to c of the approximate function of the second flow rate function characteristic are calculated by the least-squares method, and the clogging rate is calculated based on the second flow rate function characteristic and the first flow rate function approximated by the approximate function using the coefficients a to c.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

Abstract: A rotation speed of a motor is estimated based on a current value of the motor, and rotation control on the motor is performed at a first cycle. Processing for detecting a loss of synchronism in the motor based on the current value is performed at a second cycle that is shorter than the first cycle.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: A power receiving device of the disclosure includes a power generator, a detector, and a controller. The power generator includes a power receiving element that receives a power signal supplied in a wireless manner from a power feeding device, and generates direct current power on the basis of the power signal. The detector includes a detection element, and drives the detection element and detects an alternating current signal generated in the detection element, during a power receiving period in which the power receiving element receives the power signal. The controller controls the power feeding device on the basis of a detection result of the detector.

Abstract: A rotation speed of a motor is estimated based on a current value of the motor, and rotation control on the motor is performed at a first cycle. Processing for detecting a loss of synchronism in the motor based on the current value is performed at a second cycle that is shorter than the first cycle.

Abstract: A receiver of the disclosure includes: a load modulator that transmits an active load modulation signal generated by active load modulation to a reader writer, in response to a carrier signal transmitted from the reader writer; and a controller that determines whether the active load modulation signal has reached the reader writer, and controls the load modulator to retransmit the active load modulation signal, after changing a phase of the active load modulation signal with respect to the carrier signal, in a case where the controller determines that the active load modulation signal has not reached the reader writer.

Abstract: A communication apparatus according to the disclosure includes one or a plurality of sensors, a communicator that performs proximity wireless communication, and a connection section that couples one of a plurality of antennae to the communicator, on a basis of a detection result of the one or the plurality of sensors.

Abstract: A communication apparatus according to the disclosure includes one or a plurality of sensors, a communicator that performs proximity wireless communication, and a connection section that couples one of a plurality of antennae to the communicator, on a basis of a detection result of the one or the plurality of sensors.