Abstract: Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: In the present invention, a clogging rate is calculated using a first flow rate function when the degree of clogging of the throttle valve is in the reference state and a second flow rate function estimated based on the intake air volume. For each predetermined period, sample points, which are combinations of the second flow rate function and throttle valve position, are obtained, and the learning points are calculated by averaging a plurality of sample points for each predetermined position range. Based on the plurality of learning points, coefficients a to c of the approximate function of the second flow rate function characteristic are calculated by the least-squares method, and the clogging rate is calculated based on the second flow rate function characteristic and the first flow rate function approximated by the approximate function using the coefficients a to c.

Abstract: In the present invention, a clogging rate is calculated using a first flow rate function when the degree of clogging of the throttle valve is in the reference state and a second flow rate function estimated based on the intake air volume. For each predetermined period, sample points, which are combinations of the second flow rate function and throttle valve position, are obtained, and the learning points are calculated by averaging a plurality of sample points for each predetermined position range. Based on the plurality of learning points, coefficients a to c of the approximate function of the second flow rate function characteristic are calculated by the least-squares method, and the clogging rate is calculated based on the second flow rate function characteristic and the first flow rate function approximated by the approximate function using the coefficients a to c.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: Disclosed are virus-inspired compositions and preparation methods thereof, where the compositions comprise mutant papillomavirus L1 proteins that spontaneously form capsid backbones and that are conjugated to a peptide comprising an epitope to form immune redirector capsids (IRCs). The epitopes on the peptides are designed to be recognized by a subject's immune system based on the subject's preexisting immune memory developed from the subject's past exposure to the epitope through infection or vaccination. The mutant papillomavirus L1 proteins possess three mutations including an amino-terminal truncation, a carboxy-terminal truncation, and a truncation at helix four. These mutations in the L1 protein yield capsomeres that are form non-canonical T=1 geometry capsid backbones. Disclosed are uses and methods of using the compositions in treating and/or preventing cancers in subjects in need thereof.

Abstract: A rotation speed of a motor is estimated based on a current value of the motor, and rotation control on the motor is performed at a first cycle. Processing for detecting a loss of synchronism in the motor based on the current value is performed at a second cycle that is shorter than the first cycle.

Abstract: Disclosed is a new class of conjugated virus-like particles (VLPs). These conjugated VLPs bind a wide variety of tumors and comprise epitopes recognized by a prior T cell immune response already existing in a host. These epitopes are derived from pathogens or previous vaccinations (such as early childhood vaccines). This provokes the body's pre-existing cytotoxic immunity obtained through previous infection or previous childhood vaccination to be redirected to the tumor cells for the elimination of cancer, and form long-term anti-tumor immunity. The described conjugated VLPs are useful for tailoring a broad range of tumors towards a response from existing immunity circumventing the need to identify tumor antigens or generate tumor-specific immune responses.

Abstract: A power receiving device of the disclosure includes a power generator, a detector, and a controller. The power generator includes a power receiving element that receives a power signal supplied in a wireless manner from a power feeding device, and generates direct current power on the basis of the power signal. The detector includes a detection element, and drives the detection element and detects an alternating current signal generated in the detection element, during a power receiving period in which the power receiving element receives the power signal. The controller controls the power feeding device on the basis of a detection result of the detector.

Abstract: A rotation speed of a motor is estimated based on a current value of the motor, and rotation control on the motor is performed at a first cycle. Processing for detecting a loss of synchronism in the motor based on the current value is performed at a second cycle that is shorter than the first cycle.

Abstract: A receiver of the disclosure includes: a load modulator that transmits an active load modulation signal generated by active load modulation to a reader writer, in response to a carrier signal transmitted from the reader writer; and a controller that determines whether the active load modulation signal has reached the reader writer, and controls the load modulator to retransmit the active load modulation signal, after changing a phase of the active load modulation signal with respect to the carrier signal, in a case where the controller determines that the active load modulation signal has not reached the reader writer.

Abstract: A communication apparatus according to the disclosure includes one or a plurality of sensors, a communicator that performs proximity wireless communication, and a connection section that couples one of a plurality of antennae to the communicator, on a basis of a detection result of the one or the plurality of sensors.

Abstract: A communication apparatus according to the disclosure includes one or a plurality of sensors, a communicator that performs proximity wireless communication, and a connection section that couples one of a plurality of antennae to the communicator, on a basis of a detection result of the one or the plurality of sensors.

Abstract: A receiver of the disclosure includes: a load modulator that transmits an active load modulation signal generated by active load modulation to a reader writer, in response to a carrier signal transmitted from the reader writer; and a controller that determines whether the active load modulation signal has reached the reader writer, and controls the load modulator to retransmit the active load modulation signal, after changing a phase of the active load modulation signal with respect to the carrier signal, in a case where the controller determines that the active load modulation signal has not reached the reader writer.

Abstract: A power receiving device of the disclosure includes a power generator, a detector, and a controller. The power generator includes a power receiving element that receives a power signal supplied in a wireless manner from a power feeding device, and generates direct current power on the basis of the power signal. The detector includes a detection element, and drives the detection element and detects an alternating current signal generated in the detection element, during a power receiving period in which the power receiving element receives the power signal. The controller controls the power feeding device on the basis of a detection result of the detector.

Abstract: A bending apparatus for bending a metal member includes at least one die, a punch disposed on an opposite side of the die through the metal member for pressurizing the metal member by relatively moving with respect to the die to perform bending, and a knock out die for supporting the metal member when the bending is performed. Friction generated on a surface of the knock out die for receiving the metal member becomes smaller continuously or gradually from a center portion toward side portions thereof in a bending ridge line direction.

Abstract: A bending apparatus for bending a metal member includes at least one die, a punch disposed on an opposite side of the die through the metal member for pressurizing the metal member by relatively moving with respect to the die to perform bending, and a knock out die for supporting the metal member when the bending is performed. Friction generated on a surface of the knock out die for receiving the metal member becomes smaller continuously or gradually from a center portion toward side portions thereof in a bending ridge line direction.

Abstract: A bending apparatus for bending a metal member includes at least one die, a punch disposed on an opposite side of the die through the metal member for pressurizing the metal member by relatively moving with respect to the die to perform bending, and a knock out die for supporting the metal member when the bending is performed. Friction generated on a surface of the knock out die for receiving the metal member becomes smaller continuously or gradually from a center portion toward side portions thereof in a bending ridge line direction. In addition, a surface of the knock out die includes multiple grooves formed at the side portions thereof in the bending ridge line direction, and widths of the multiple grooves become larger continuously or gradually from the center portion toward the side portions of the knock out die in the bending ridge line direction.

Abstract: Two dimensional developed view data of a three dimensional structure is obtained. Layer structure information of a sheet-shaped component which has a laminated structure, and bend information of a indicated by the obtained data are input. For coordinates of the obtained data, a principal axis direction in which the shape of an inner structure of the component does not change is set. The layer structure information and information representing the principal axis direction are added to each surface indicated by the obtained data. The three dimensional shape of the three dimensional structure is generated using the obtained data and the bend information. Using the layer structure information and the information representing the principal axis direction added to each surface, a three dimensional model in which the shape of the laminated structure of the component is added to each surface indicated by the three dimensional shape is generated.

Abstract: An information processing apparatus that receives image data sent from a sending apparatus in packet communications, the information processing apparatus includes: a receiving unit adapted to receive a packet for transmitting the image data; a detecting unit adapted to detect a transmission error in the packet; and a sending unit adapted to send a retransmission request for a packet in which the detecting unit has detected a transmission error to the sending apparatus; wherein, when the detecting unit has detected a transmission error in a packet that corresponds to a region of interest that has been preset in the image data, the sending unit sends a retransmission request for the packet with a higher priority than a transmission request for a packet that does not correspond to the region of interest.