Abstract: The present invention relates to therapies and therapeutic agents for use in the treatment of cardiomyopathies. In particular, the invention is concerned with, but not limited to therapies and therapeutic agents for use in the treatment of hypertrophic cardiomyopathy. Such therapeutic agents comprise hypomethylating agents.

Abstract: The present invention relates to therapies and therapeutic agents for use in the treatment of cardiomyopathies. In particular, the invention is concerned with, but not limited to therapies and therapeutic agents for use in the treatment of hypertrophic cardiomyopathy. Such therapeutic agents comprise hypomethylating agents.

Abstract: The invention provides methods of detecting a natriuretic protein, a troponin, and galectin-3 in samples from subjects in order to determine risk of developing new onset heart failure with preserved ejection fraction (HFpEF).

Abstract: A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-existence of abnormalities of MMP enzymes and inflammation in many diseases make these characteristics advantageous. Therefore, the various combinations of the invention find utility in medical applications where MMPs and/or inflammation is implicated.

Abstract: The present invention relates to therapies and therapeutic agents for use in the treatment of cardiomyopathies. In particular, the invention is concerned with, but not limited to therapies and therapeutic agents for use in the treatment of hypertrophic cardiomyopathy. Such therapeutic agents comprise hypomethylating agents.

Abstract: A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-existence of abnormalities of MMP enzymes and inflammation in many diseases make these characteristics advantageous. Therefore, the various combinations of the invention find utility in medical applications where MMPs and/or inflammation is implicated.

Abstract: A machine management system, including one or more sensors arranged to take readings of one or more operating variables for a machine. Data processing equipment is arranged to receive data indicative of said operating variable readings for the machine and to analyse the received operational data to determine a probability distribution there-for. The processing equipment includes one or more modules of machine-readable code for assigning a value to one or more Stable distribution parameters in dependence on the received operational data, and a departure in the machine operation from a predetermined normal operating condition is determined from the assigned distribution parameter.

Abstract: A mechanized exterminator and several embodiments thereof are presented. A drive mechanism operates a support mechanism having rollers attached thereto and which roll over a base, crushing insects such as fire ants. The drive mechanism may be powered by battery or other forms of electricity or may be solar or wind powered. The exterminator is cost-effective and environmentally safe. The exterminator severely impacts the strength and health of the colony minimizing its ability to reproduce.

Abstract: A system for exterminating insects and several embodiments thereof are presented. Steam is generated and transported to a movable applicator. The applicator is positioned over a designated area of ground and the steam is applied exterminating the insects on and/or under the designated area of ground.

Abstract: A system for exterminating insects and several embodiments thereof are presented. Steam is generated and transported to a movable applicator. The applicator is positioned over a designated area of ground and the steam is applied exterminating the insects on and/or under the designated area of ground.

Abstract: A clockspring device that includes an outer housing with a circumferential wall that defines a chamber. The circumferential wall includes a vertically-oriented track. A rotor having a keyway is configured to fit at least partially within the outer housing. A coil of cable is positioned within the chamber and has a first end and a second end. The first end of the coil of cable is attached to the rotor and the second end of the coil of cable is attached to the outer housing. A clip having a first end, a second end, and a middle portion is configured to fit within the vertically-oriented track. The middle portion of the clip has two flexible tabs. Each flexible tab has a portion that extends away from the middle portion. The flexible tabs are compressed or bent in order to insert the clip in the track and slide it along the track and into an engaged position. When the clip is in the engaged position, the position of the rotor is fixed with respect to the outer housing.

Abstract: A mechanized exterminator and several embodiments thereof are presented. A support disc with rollers attached rotates when power is applied causing rollers to roll over a base. The operation of the of the exterminator disturbs the insects causing them to enter the exterminator where the rollers will crush them. Solar, battery and/or wind power can be used to power the exterminator. The exterminator is cost-effective and environmentally safe. The exterminator severely impacts the strength and health of the colony minimizing its ability to reproduce.

Abstract: A mechanized system for exterminating and several embodiments thereof are presented. Steam is generated and transported to a movable applicator. The applicator is positioned over a designated area of ground and the steam is applied exterminating the insects on and/or under the designated area of ground.

Abstract: A mechanized exterminator and several embodiments thereof are presented. A drive mechanism operates a support mechanism having rollers attached thereto and which roll over a base, crushing insects such as fire ants. The drive mechanism may be powered by battery or other forms of electricity or may be solar or wind powered. The exterminator is cost-effective and environmentally safe. The exterminator severely impacts the strength and health of the colony minimizing its ability to reproduce.