Patents by Inventor Ken Mizuno

Ken Mizuno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220047585
    Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.
    Type: Application
    Filed: November 1, 2021
    Publication date: February 17, 2022
    Applicant: KOWA CO., LTD.
    Inventors: Shin SUGIMOTO, Ken MIZUNO, Masatoshi TAKAHASHI, Makoto KANEBAKO
  • Publication number: 20210052599
    Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Applicant: KOWA CO., LTD.
    Inventor: Ken MIZUNO
  • Publication number: 20200030340
    Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.
    Type: Application
    Filed: September 4, 2019
    Publication date: January 30, 2020
    Applicant: KOWA CO., LTD.
    Inventor: Ken MIZUNO
  • Publication number: 20190365776
    Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
    Type: Application
    Filed: August 16, 2019
    Publication date: December 5, 2019
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KOWA COMPANY, LTD.
    Inventors: Tatsuro Ishibashi, Shintaro Nakao, Ryoichi Arita, Ken Mizuno, Akifumi Tsuchiura
  • Publication number: 20190328730
    Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Applicant: KOWA CO., LTD.
    Inventors: Shin SUGIMOTO, Ken MIZUNO, Masatoshi TAKAHASHI, Makoto KANEBAKO
  • Patent number: 10426783
    Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 1, 2019
    Assignees: KYUSHU UNIVERSITY, NAT'L UNIVERSITY CORPORATION, KOWA COMPANY, LTD.
    Inventors: Tatsuro Ishibashi, Shintaro Nakao, Ryoichi Arita, Ken Mizuno, Akifumi Tsuchiura
  • Publication number: 20180185384
    Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.
    Type: Application
    Filed: February 27, 2018
    Publication date: July 5, 2018
    Applicant: KOWA CO., LTD.
    Inventor: Ken MIZUNO
  • Publication number: 20170100409
    Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
    Type: Application
    Filed: December 21, 2016
    Publication date: April 13, 2017
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KOWA COMPANY, LTD.
    Inventors: Tatsuro Ishibashi, Shintaro Nakao, Ryoichi Arita, Ken Mizuno, Akifumi Tsuchiura
  • Publication number: 20170020889
    Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.
    Type: Application
    Filed: October 4, 2016
    Publication date: January 26, 2017
    Applicant: KOWA CO., LTD.
    Inventor: Ken MIZUNO
  • Patent number: 9514127
    Abstract: A computer implemented method, a program, and a system for effectively providing versatile non-text information suitable for use in a multi-language environment. The method includes the steps of: receiving search results of a database using a search criterion in a certain language and a search criterion in another language corresponding to the search criterion in which specific language attributes are associated with non-text elements that are included in the search results; scoring the non-text elements included in the search results depending on a similarity to another element with which a different language attribute is associated; and identifying at least one of the non-text elements included in the search results on the basis of the scores.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: December 6, 2016
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yasuharu Katsuno, Kohtaroh Miyamoto, Ken Mizuno, Sachiko Yoshihama
  • Publication number: 20160339018
    Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
    Type: Application
    Filed: March 3, 2014
    Publication date: November 24, 2016
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KOWA COMPANY, LTD.
    Inventors: Tatsuro Ishibashi, Shintaro Nakao, Ryoichi Arita, Ken Mizuno, Akifumi Tsuchiura
  • Patent number: 9483385
    Abstract: To provide a technique for generating, at a high speed, a smaller-sized set that satisfies an intended property such as, for example, being pair-wise, and includes many test cases that match a set of existing test cases given as an input, candidates to be used from a set of existing input test cases are determined in the following manner: for some parameters, values to be held by test case candidates are determined; test cases having the determined values, among those included in the set of input test cases, are selected as the candidates. A test case having the highest score among one or more test case candidates generated with the method of the related art and one or more test case candidates selected from the set of input test cases is added to a set of output test cases.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: November 1, 2016
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ken Mizuno, Taiga Nakamura, Hironori Takeuchi
  • Patent number: 9465724
    Abstract: To provide a technique for generating, at a high speed, a smaller-sized set that satisfies an intended property such as, for example, being pair-wise, and includes many test cases that match a set of existing test cases given as an input, candidates to be used from a set of existing input test cases are determined in the following manner: for some parameters, values to be held by test case candidates are determined; test cases having the determined values, among those included in the set of input test cases, are selected as the candidates. A test case having the highest score among one or more test case candidates generated with the method of the related art and one or more test case candidates selected from the set of input test cases is added to a set of output test cases.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: October 11, 2016
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ken Mizuno, Taiga Nakamura, Hironori Takeuchi
  • Patent number: 8987905
    Abstract: A semiconductor package includes a semiconductor device and a substrate, the semiconductor device including a straight line portion on an outer periphery and the substrate supporting the semiconductor device. A foil positioning pattern is formed on a front surface of the substrate, the positioning pattern touching the straight line portion of the semiconductor device to regulate a position of the semiconductor device.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: March 24, 2015
    Assignee: Mitutoyo Corporation
    Inventors: Toru Yaku, Ken Mizuno
  • Patent number: 8965887
    Abstract: A test case generation method includes in a processor, extracting descriptions from document artifacts, extracting a first set of keywords from the descriptions, categorizing the descriptions to a first set and a second set, extracting a second set of keywords that occur in the second set and generating a test case from the second set of keywords.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: February 24, 2015
    Assignee: International Business Machines Corporation
    Inventors: Futoshi Iwama, Ken Mizuno, Taiga Nakamura, Hironori Takeuchi
  • Publication number: 20140378441
    Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
    Type: Application
    Filed: September 9, 2014
    Publication date: December 25, 2014
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KOWA COMPANY, LTD.
    Inventors: Tatsuro Ishibashi, Shintaro Nakao, Ryoichi Arita, Ken Mizuno, Akifumi Tsuchiura
  • Patent number: 8838607
    Abstract: A test case generation system includes a processor, a process residing on the processor and configured to extract descriptions from document artifacts, extract a first set of keywords from the descriptions, categorize the descriptions to a first set and a second set, extract a second set of keywords that occur in the second set and generate a test case from the second set of keywords.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: September 16, 2014
    Assignee: International Business Machines Corporation
    Inventors: Futoshi Iwama, Ken Mizuno, Taiga Nakamura, Hironori Takeuchi
  • Publication number: 20140108410
    Abstract: A test case generation system includes a processor, a process residing on the processor and configured to extract descriptions from document artifacts, extract a first set of keywords from the descriptions, categorize the descriptions to a first set and a second set, extract a second set of keywords that occur in the second set and generate a test case from the second set of keywords.
    Type: Application
    Filed: October 17, 2012
    Publication date: April 17, 2014
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Futoshi Iwama, Ken Mizuno, Taiga Nakamura, Hironori Takeuchi
  • Publication number: 20140109054
    Abstract: A test case generation method includes in a processor, extracting descriptions from document artifacts, extracting a first set of keywords from the descriptions, categorizing the descriptions to a first set and a second set, extracting a second set of keywords that occur in the second set and generating a test case from the second set of keywords.
    Type: Application
    Filed: October 31, 2012
    Publication date: April 17, 2014
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Futoshi Iwama, Ken Mizuno, Taiga Nakamura, Hironori Takeuchi
  • Publication number: 20140094451
    Abstract: There is provided a preventive for glaucoma or a preventive or a remedy for ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. A preventive or a remedy for glaucoma comprising a Rho kinase inhibitor and an ?1 blocker in combination.
    Type: Application
    Filed: December 6, 2013
    Publication date: April 3, 2014
    Applicant: Kowa Co., Ltd.
    Inventors: Ken MIZUNO, Jiro MATSUMOTO