Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.

Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.

Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.

Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.

Abstract: A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.

Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.

Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.

Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.

Abstract: There is provided a drug therapy for prevention of glaucoma or prevention or treatment of ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. Disclosed is a combination of (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof, and a prostaglandin for prevention or treatment of glaucoma.

Abstract: A computer implemented method, a program, and a system for effectively providing versatile non-text information suitable for use in a multi-language environment. The method includes the steps of: receiving search results of a database using a search criterion in a certain language and a search criterion in another language corresponding to the search criterion in which specific language attributes are associated with non-text elements that are included in the search results; scoring the non-text elements included in the search results depending on a similarity to another element with which a different language attribute is associated; and identifying at least one of the non-text elements included in the search results on the basis of the scores.

Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.

Abstract: To provide a technique for generating, at a high speed, a smaller-sized set that satisfies an intended property such as, for example, being pair-wise, and includes many test cases that match a set of existing test cases given as an input, candidates to be used from a set of existing input test cases are determined in the following manner: for some parameters, values to be held by test case candidates are determined; test cases having the determined values, among those included in the set of input test cases, are selected as the candidates. A test case having the highest score among one or more test case candidates generated with the method of the related art and one or more test case candidates selected from the set of input test cases is added to a set of output test cases.

Abstract: To provide a technique for generating, at a high speed, a smaller-sized set that satisfies an intended property such as, for example, being pair-wise, and includes many test cases that match a set of existing test cases given as an input, candidates to be used from a set of existing input test cases are determined in the following manner: for some parameters, values to be held by test case candidates are determined; test cases having the determined values, among those included in the set of input test cases, are selected as the candidates. A test case having the highest score among one or more test case candidates generated with the method of the related art and one or more test case candidates selected from the set of input test cases is added to a set of output test cases.

Abstract: A semiconductor package includes a semiconductor device and a substrate, the semiconductor device including a straight line portion on an outer periphery and the substrate supporting the semiconductor device. A foil positioning pattern is formed on a front surface of the substrate, the positioning pattern touching the straight line portion of the semiconductor device to regulate a position of the semiconductor device.

Abstract: A test case generation method includes in a processor, extracting descriptions from document artifacts, extracting a first set of keywords from the descriptions, categorizing the descriptions to a first set and a second set, extracting a second set of keywords that occur in the second set and generating a test case from the second set of keywords.

Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(?)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.

Abstract: A test case generation system includes a processor, a process residing on the processor and configured to extract descriptions from document artifacts, extract a first set of keywords from the descriptions, categorize the descriptions to a first set and a second set, extract a second set of keywords that occur in the second set and generate a test case from the second set of keywords.

Abstract: A test case generation method includes in a processor, extracting descriptions from document artifacts, extracting a first set of keywords from the descriptions, categorizing the descriptions to a first set and a second set, extracting a second set of keywords that occur in the second set and generating a test case from the second set of keywords.

Abstract: A test case generation system includes a processor, a process residing on the processor and configured to extract descriptions from document artifacts, extract a first set of keywords from the descriptions, categorize the descriptions to a first set and a second set, extract a second set of keywords that occur in the second set and generate a test case from the second set of keywords.

Abstract: There is provided a preventive for glaucoma or a preventive or a remedy for ocular hypertension, with a potent ocular hypotensive effect and prolonged duration thereof. A preventive or a remedy for glaucoma comprising a Rho kinase inhibitor and an ?1 blocker in combination.