Patents by Inventor Ken Mukai

Ken Mukai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240390340
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
    Type: Application
    Filed: April 17, 2024
    Publication date: November 28, 2024
    Inventors: Onur ATASOYLU, Peter Carlsen, Suman Chakrabarty, Bin Hu, Chengtsung Lai, Chunyin Marshall Law, Gencheng Li, Matthew McCammant, Rocco Policarpo, III, Ken Mukai, Alexander Sokolsky, Xiaozhao Wang, Fenglei Zhang, Robert Susick
  • Patent number: 12030883
    Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: July 9, 2024
    Assignee: Incyte Corporation
    Inventors: Peter Carlsen, Ken Mukai, Haolin Yin, Xiaozhao Wang, Wenqing Yao, Wenyu Zhu
  • Patent number: 11686019
    Abstract: The purpose of the present disclosure is to provide a CNT fiber that is constituted of aligned carbon nanotubes (CNTs), is thin, has little irregularity in thickness, has excellent winding properties when undergoing coiling processing, and has superior conductivity. Provided is a CNT fiber constituted of carbon nanotubes (CNTs) having a thickness of 0.01 ?m-3 mm, having a coefficient of variation for irregularity in thickness of 0.2 or less, having a distribution rate a for deviation from roundness of 40% or greater, and a distribution rate b of 70% or greater. Also provided is a method for manufacturing the CNT fiber.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 27, 2023
    Assignees: National Institute of Advanced Industrial Science and Technology, Asahi Kasei Kabushiki Kaisha
    Inventors: Ken Mukai, Shuhei Ikenaga, Kinji Asaka, Toru Morita, Yujin Motoyama, Yuta Saito
  • Publication number: 20230151005
    Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
    Type: Application
    Filed: September 20, 2022
    Publication date: May 18, 2023
    Inventors: Peter Carlsen, Ken Mukai, Haolin Yin, Xiaozhao Wang, Wenqing Yao, Wenyu Zhu
  • Publication number: 20230114765
    Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
    Type: Application
    Filed: July 13, 2022
    Publication date: April 13, 2023
    Inventors: Zhenwu Li, Zhiyong YU, Jeremy Roach, Gia Hoang, Bin HU, Gencheng Li, Rory McAtee, Ken Mukai, Rocco Policarpo, Robert Susick, Xiaozhao Wang, Wenqing Yao
  • Publication number: 20230024173
    Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: July 29, 2022
    Publication date: January 26, 2023
    Inventors: Qinda Ye, Jingwei Li, Ken Mukai, Brandon Smith, Liangxing Wu, Wenqing Yao, Min Ye, Yingnan Chen, Margaret Favata, Yvonne Lo
  • Patent number: 11447494
    Abstract: The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), of Formula (I): as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: September 20, 2022
    Assignee: Incyte Corporation
    Inventors: Qinda Ye, Ken Mukai, Liangxing Wu, Wenqing Yao
  • Patent number: 11440914
    Abstract: The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: September 13, 2022
    Assignee: Incyte Corporation
    Inventors: Qinda Ye, Neil Lajkiewicz, Ken Mukai, Liangxing Wu, Wenqing Yao
  • Patent number: 11427567
    Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: August 30, 2022
    Assignee: Incyte Corporation
    Inventors: Qinda Ye, Jingwei Li, Ken Mukai, Brandon Smith, Liangxing Wu, Wenqing Yao, Min Ye, Yingnan Chen, Margaret Favata, Yvonne Lo
  • Patent number: 11084725
    Abstract: An object of the present invention is to provide a CNT yarn having excellent conductivity and strength, and a method for producing the same. The present invention provides a drawn yarn comprising carbon nanotubes and having a drawing rate of 10 to 50%.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: August 10, 2021
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Ken Mukai, Kinji Asaka, Takeshi Saito, Motoo Yumura
  • Publication number: 20210071320
    Abstract: The purpose of the present disclosure is to provide a CNT fiber that is constituted of aligned carbon nanotubes (CNTs), is thin, has little irregularity in thickness, has excellent winding properties when undergoing coiling processing, and has superior conductivity. Provided is a CNT fiber constituted of carbon nanotubes (CNTs) having a thickness of 0.01 ?m-3 mm, having a coefficient of variation for irregularity in thickness of 0.2 or less, having a distribution rate a for deviation from roundness of 40% or greater, and a distribution rate b of 70% or greater. Also provided is a method for manufacturing the CNT fiber.
    Type: Application
    Filed: October 11, 2018
    Publication date: March 11, 2021
    Applicants: National Institute of Advanced Industrial Science and Technology, Asahi Kasei Kabushiki Kaisha
    Inventors: Ken Mukai, Shuhei Ikenaga, Kinji Asaka, Toru Morita, Yujin Motoyama, Yuta Saito
  • Publication number: 20210047294
    Abstract: The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: August 13, 2020
    Publication date: February 18, 2021
    Inventors: Qinda Ye, Jingwei Li, Ken Mukai, Brandon Smith, Liangxing Wu, Wenqing Yao, Min Ye, Yingnan Chen, Margaret Favata, Yvonne Lo
  • Publication number: 20200347066
    Abstract: The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Qinda Ye, Ken Mukai, Liangxing Wu, Wenqing Yao
  • Publication number: 20200347067
    Abstract: The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Qinda Ye, Neil Lajkiewicz, Ken Mukai, Liangxing Wu, Wenqing Yao
  • Publication number: 20190210878
    Abstract: An object of the present invention is to provide a CNT yarn having excellent conductivity and strength, and a method for producing the same. The present invention provides a drawn yarn comprising carbon nanotubes and having a drawing rate of 10 to 50%.
    Type: Application
    Filed: March 13, 2019
    Publication date: July 11, 2019
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Ken MUKAI, Kinji ASAKA, Takeshi SAITO, Motoo YUMURA
  • Patent number: 10273157
    Abstract: An object of the present invention is to provide a CNT yarn having excellent conductivity and strength, and a method for producing the same. The present invention provides a drawn yarn comprising carbon nanotubes and having a drawing rate of 10 to 50%.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: April 30, 2019
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Ken Mukai, Kinji Asaka, Takeshi Saito, Motoo Yumura
  • Patent number: 9424960
    Abstract: A method for producing an aggregated thread structure includes (a) a process of dispersing carbon nanotube to a first solvent, which is water or a mixed solvent containing organic solvent and water, with a surfactant, to create a dispersion and (b) a process of injecting the dispersion, in which carbon nanotube is dispersed, to a condensing liquid, which is a second solvent that differs from the first solvent, to thereby aggregate and spin carbon nanotube. The aggregated thread structure containing carbon nanotube has: a bulk density of 0.5 g/cm3 or more; a weight reduction rate up to 450° C. of 50% or less; a G/D ratio for resonance Raman scattering measurement of 10 or more; and an electric conductivity of 50 S/cm or more.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: August 23, 2016
    Assignees: FURUKAWA ELECTRIC CO., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hiroaki Rikihisa, Masato Tachibana, Michihiro Shimada, Kinji Asaka, Ken Mukai, Takushi Sugino
  • Publication number: 20160083257
    Abstract: An object of the present invention is to provide a CNT yarn having excellent conductivity and strength, and a method for producing the same. The present invention provides a drawn yarn comprising carbon nanotubes and having a drawing rate of 10 to 50%.
    Type: Application
    Filed: May 15, 2014
    Publication date: March 24, 2016
    Inventors: Ken Mukai, Kinji Asaka, Takeshi Saito, Motoo Yumura
  • Publication number: 20140346697
    Abstract: A method for producing an aggregated thread structure includes (a) a process of dispersing carbon nanotube to a first solvent, which is water or a mixed solvent containing organic solvent and water, with a surfactant, to create a dispersion and (b) a process of injecting the dispersion, in which carbon nanotube is dispersed, to a condensing liquid, which is a second solvent that differs from the first solvent, to thereby aggregate and spin carbon nanotube. The aggregated thread structure containing carbon nanotube has: a bulk density of 0.5 g/cm3 or more; a weight reduction rate up to 450° C. of 50% or less; a G/D ratio for resonance Raman scattering measurement of 10 or more; and an electric conductivity of 50 S/cm or more.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: Hiroaki RIKIHISA, Masato TACHIBANA, Michihiro SHIMADA, Kinji ASAKA, Ken MUKAI, Takushi SUGINO
  • Publication number: 20130251619
    Abstract: A method for producing an aggregated thread structure includes (a) a process of dispersing carbon nanotube to a first solvent, which is water or a mixed solvent containing organic solvent and water, with a surfactant, to create a dispersion and (b) a process of injecting the dispersion, in which carbon nanotube is dispersed, to a condensing liquid, which is a second solvent that differs from the first solvent, to thereby aggregate and spin carbon nanotube. The aggregated thread structure containing carbon nanotube has: a bulk density of 0.5 g/cm3 or more; a weight reduction rate up to 450° C. of 50% or less; a G/D ratio for resonance Raman scattering measurement of 10 or more; and an electric conductivity of 50 S/cm or more.
    Type: Application
    Filed: May 20, 2013
    Publication date: September 26, 2013
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, FURUKAWA ELECTRIC CO., LTD.
    Inventors: Hiroaki RIKIHISA, Masato TACHIBANA, Michihiro SHIMADA, Kinji ASAKA, Ken MUKAI, Takushi SUGINO