Abstract: The present invention relates to methods of diagnosing hypophosphatemic disorders.

Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.

Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.

Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.

Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.

Abstract: The present invention relates to antibodies that bind to FGF23 polypeptides and to FGF23 mutant polypeptides.

Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.

Abstract: A system and method are disclosed for utilizing compression in database caches to facilitate access to database information. In contrast with applying compression to the database that is stored on disk, the present invention achieves performance advantages by using compression within the main memory database cache used by a database management system to manage data transfers to and from a physical database file stored on a storage system or stored on a networked attached device or node. The disclosed system and method thereby provide a significant technical advantage by increasing the effective database cache size. And this effective increase in database cache size can greatly enhance the operations-per-second capability of a database management system by reducing unnecessary disk or network accesses thereby reducing data access times.

Abstract: The present invention provides functional client side data cache coherence distributed across database servers and clients. This system includes an application resident on a client operable to request access to data, and wherein the client is coupled to a local memory cache operable to store requested date. The client is coupled to a remote memory storage system, such as disk storage or network resources by a communication pathway. This remote memory storage system is operable to store data, process requests for specified data, retrieve the specified data from within the remote memory storage system, and transmit the requested data to the client with annotated version information. The data received by the client is verified as being coherent with any downstream linked information stored in the client's local memory cache. Otherwise, updated coherent data is requested, received and verified prior to being used by the client and its resident applications.

Abstract: A system and method are disclosed for improving the efficiency of write operations by intelligently managing disk pages that are written during checkpoint operations so that write operations can occur with reduced numbers of writes. As write data is received and cached, for example, by a database application, disk pages are allocated to the write data. When a checkpoint operation is taken to write the data cache to disk as modifications or additions to the database file, an intelligent write management module re-assesses the disk page allocation and re-maps disk writes to improve the efficiency of disk input/output (I/O) operations. As such, significant improvements in the speed and efficiency of database operations during checkpoint events are achieved.

Abstract: A system and method are disclosed for utilizing compression in database caches to facilitate access to database information. In contrast with applying compression to the database that is stored on disk, the present invention achieves performance advantages by using compression within the main memory database cache used by a database management system to manage data transfers to and from a physical database file stored on a storage system or stored on a networked attached device or node. The disclosed system and method thereby provide a significant technical advantage by increasing the effective database cache size. And this effective increase in database cache size can greatly enhance the operations-per-second capability of a database management system by reducing unnecessary disk or network accesses thereby reducing data access times.

Abstract: The present invention provides functional client side data cache coherence distributed across database servers and clients. This system includes an application resident on a client operable to request access to data, and wherein the client is coupled to a local memory cache operable to store requested date. The client is coupled to a remote memory storage system, such as disk storage or network resources by a communication pathway. This remote memory storage system is operable to store data, process requests for specified data, retrieve the specified data from within the remote memory storage system, and transmit the requested data to the client with annotated version information. The data received by the client is verified as being coherent with any downstream linked information stored in the client's local memory cache. Otherwise, updated coherent data is requested, received and verified prior to being used by the client and its resident applications.

Abstract: A system and method are disclosed for improving the efficiency of write operations by intelligently managing disk pages that are written during checkpoint operations so that write operations can occur with reduced numbers of writes. As write data is received and cached, for example, by a database application, disk pages are allocated to the write data. When a checkpoint operation is taken to write the data cache to disk as modifications or additions to the database file, an intelligent write management module re-assesses the disk page allocation and re-maps disk writes to improve the efficiency of disk input/output (I/O) operations. As such, significant improvements in the speed and efficiency of database operations during checkpoint events are achieved.

Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.

Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.