Patents by Inventor Ken Yamada

Ken Yamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12022015
    Abstract: One variation of a method for secure and distributed timekeeping includes: at a node in a set of nodes in a network, at a first time, sampling two time sources and calculating a minor consensus time between the two time sources; in response to designation of the node as a leader node, accessing a second minor consensus time generated by a second node, accessing a third minor consensus time generated by a third node, calculating a first major consensus time between the first, second, and third minor consensus times, and distributing a request to validate the first major consensus time; and, based on validation of the request from a threshold quantity of nodes, cryptographically hashing a hash of a previous block and the major consensus time to generate a first block and distributing the first block to each node in the set of nodes.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: June 25, 2024
    Assignee: D4D Group
    Inventor: Ken Yamada
  • Patent number: 12009945
    Abstract: A communication system includes a first communication device, a second communication device and a relay device. The first and second communication devices are connected to a communication network. The relay device is connected to the communication network and relays communication between the first and second communication devices. The relay device includes a relay unit and a priority determination unit. The relay unit carries out a receiving process for receiving data frames transmitted from the first communication device to the communication network and a transmission process for transmitting the received data frames to the second communication device. The priority determination unit determines the priority of the transmission process of the received data frames based on the data frames received by the relay unit. The relay unit carries out a transmission process of the data frames based on the priority determined by the priority determination unit.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: June 11, 2024
    Assignees: Nissan Motor Co., Ltd., Renault S.A.S.
    Inventors: Ken Naka, Takashi Yamaguchi, Hideaki Yamada
  • Publication number: 20240183076
    Abstract: The present disclosure generally relates to compositions, methods, sorters, systems, devices and uses for screening for bioactive substances in emulsion droplets. In some embodiments, the compositions are a continuous phase formulation for stable emulsions, In some embodiments, the methods are for preparing a monodisperse polyethylene glycol acrylamide (PEGA) co-polymer resin, or for preparing a core-shell bead. In some embodiments, the systems and devices include a sorter, comprising an inlet channel, first and second outlet channels meeting the inlet channel at a junction, and first and second electrodes proximate respective first and second sides of the junction sorter.
    Type: Application
    Filed: March 9, 2022
    Publication date: June 6, 2024
    Inventors: Asitha Adrian ABEYWARDANE, Tushar Dattu APSUNDE, Gianluca Nicolas ETIENNE, Alessia GAMBARDELLA, James Kevin MAINQUIST, Andrew J. MEYER, Brian MINIE, Steven PAULA, Dwayne A. L. VICKERS, Ken YAMADA
  • Publication number: 20240167029
    Abstract: Extended Nucleic Acid (exNA)-modified crRNAs and tracrRNAs are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: June 23, 2023
    Publication date: May 23, 2024
    Inventors: Anastasia Khvorova, Ken Yamada, Erik Joseph Sontheimer
  • Publication number: 20240158605
    Abstract: An elastomer composition contains a solvent in a proportion of not less than 1 part by mass and less than 60 parts by mass per 100 parts by mass of an elastomer. The solvent includes an organic solvent A having high affinity with carbon nanotubes and having a boiling point of 200° C. or lower and an organic solvent B having high affinity with the elastomer and having a boiling point of 200° C. or lower. The solvent results in the elastomer having a volume swelling degree of 150% or more and has a relative energy difference (REDCNT) of 1.5 or less.
    Type: Application
    Filed: March 30, 2022
    Publication date: May 16, 2024
    Applicants: ZEON CORPORATION, National Institute of Advanced Industrial Science and Technology
    Inventors: Yoshihisa TAKEYAMA, Masahiro UENO, Ryoichi KISHI, Ken KOKUBO, Takeo YAMADA
  • Publication number: 20240141362
    Abstract: This disclosure relates to novel modified oligonucleotides. Novel modified siRNA are also provided.
    Type: Application
    Filed: September 1, 2023
    Publication date: May 2, 2024
    Inventors: Anastasia Khvorova, Loïc Maurice René Jean Roux, Ken Yamada
  • Publication number: 20240132888
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Application
    Filed: August 9, 2023
    Publication date: April 25, 2024
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Patent number: 11942569
    Abstract: In various embodiments, degradation of epoxy within packages for ultraviolet light-emitting devices is reduced or substantially eliminated via package venting, prevention of transmission of ultraviolet light to one or more regions of epoxy utilized in the package, and/or utilization of packaging schemes that reduce or avoid utilization of epoxy and/or specific metals.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: March 26, 2024
    Assignee: CRYSTAL IS, INC.
    Inventors: Masato Toita, Satoshi Yamada, Ken Kitamura, Craig Moe, Amy Miller
  • Publication number: 20240097590
    Abstract: A motor controller includes a first control circuit, a second control circuit, a determination circuit, and a command circuit. The first control circuit outputs a first control value based on a rule base from a command value of an angular velocity and a measured value of an angular velocity. The second control circuit outputs a second control value based on a learned model from the command value of the angular velocity and the measured value of the angular velocity. The determination circuit determines a state based on at least the second control value. The command circuit acquires and outputs a control command value from the first control value and the second control value based on a result determined by the determination circuit.
    Type: Application
    Filed: February 28, 2023
    Publication date: March 21, 2024
    Inventors: Yutaka YAMADA, Koji SUZUKI, Ken TANABE
  • Patent number: 11921341
    Abstract: An optical cable includes: twisted optical fiber units each including a fiber group formed by optical fibers. At least one of the optical fiber units includes a filling that wraps an outer circumference of the fiber group.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: March 5, 2024
    Assignees: Fujikura Ltd., NIPPON TELEGRAPH AND TELEPHONE CORPORATION
    Inventors: Masatoshi Ohno, Akira Namazue, Ken Osato, Yusuke Yamada, Yuta Maruo, Akira Sakurai, Shigekatsu Tetsutani, Hiroaki Tanioka
  • Publication number: 20240066132
    Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.
    Type: Application
    Filed: July 14, 2023
    Publication date: February 29, 2024
    Inventors: David Weninger BARNES, Avirup BOSE, Alexandra Marshall BRUCE, Alokesh DUTTAROY, Chikwendu IBEBUNJO, Aaron KANTER, Louise Clare KIRMAN, Changgang LOU, Aimee Richardson USERA, Ken YAMADA, Jun YUAN, Frederic ZECRI
  • Patent number: 11913717
    Abstract: A natural gas liquefying apparatus includes: a precooling unit, which is a treatment unit configured to precool natural gas; a liquefying unit, which is a treatment unit configured to liquefy the natural gas; a refrigerant cooling unit, which is a treatment unit configured to cool a liquefying refrigerant; a compression unit configured to compress vaporized refrigerants; and a pipe rack including air-cooled coolers arrayed and arranged on an upper surface. The treatment units and the compression unit are separately arranged in a first arrangement region and a second arrangement region arranged opposed to each other across a long side of the pipe rack. The pipe rack interposed between the first and second arrangement regions has a region in which no air-cooled cooler is arranged in order to arrange a plurality of pipes, through which refrigerants are allowed to flow, in a direction of a short side of the pipe rack.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 27, 2024
    Assignee: JGC CORPORATION
    Inventors: Yoshinori Yamada, Kaoru Sawayanagi, Tomoharu Inoue, Yuichi Yoshizawa, Masahito Seiwa, Ken Ichimura
  • Patent number: 11827882
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: November 28, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Patent number: 11820985
    Abstract: This disclosure relates to novel modified oligonucleotides. Novel modified siRNA are also provided.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: November 21, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Loïc Maurice René Jean Roux, Ken Yamada
  • Patent number: 11767527
    Abstract: Novel oligonucleotides that enhance silencing of the expression of a gene containing a single nucleotide polymorphism (SNP) relative to the expression of the corresponding wild-type gene are provided. Methods of using novel oligonucleotides that enhance silencing of the expression of a gene containing a SNP relative to the expression of the corresponding wild-type gene are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Faith Conroy, Edith Pfister, Neil Aronin, Ken Yamada
  • Publication number: 20230021431
    Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
    Type: Application
    Filed: May 28, 2021
    Publication date: January 26, 2023
    Inventors: Anastasia Khvorova, Jonathan Watts, Zachary Kennedy, Annabelle Biscans, Bruno Miguel da Cruz Godinho, Chantal Ferguson, Dimas Echeverria Moreno, Ken Yamada, Daniel O'Reilly, Kathryn Monopoli, Vignesh Narayan Hariharan, Qi Tang, Sarah Davis, Samuel Hildebrand, Socheata Ly, Minwook Shin, Pranathi Meda Krishnamurthy, Nicholas McHugh, Jacquelyn Sousa, Jillian Caiazzi, Yann Thillier, Gitali Devi
  • Patent number: 11530213
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: December 20, 2022
    Assignee: Novartis AG
    Inventors: Guillaume Barbe, Gregory Raymond Bebernitz, Sicong Geng, Hatice Belgin Gulgeze Efthymiou, Lv Liao, Fupeng Ma, Ruowei Mo, David Thomas Parker, Yunshan Peng, Stefan Peukert, Nichola Smith, Ken Yamada, Kayo Yasoshima
  • Publication number: 20220387602
    Abstract: Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.
    Type: Application
    Filed: September 14, 2020
    Publication date: December 8, 2022
    Inventors: Luca ARISTA, Valerie BROENNIMANN, Pier Luca D'ALESSANDRO, Lionel DOUMAMPOUOM-METOUL, Marie-Line GOUDE, Christina HEBACH, Gregory John HOLLINGWORTH, Ingrid Karen Jennifer JEULIN, Louise Clare KIRMAN, Julien LORBER, Fupeng MA, Anna VULPETTI, Ken YAMADA, Thomas ZOLLER
  • Publication number: 20220393888
    Abstract: One variation of a method for secure and distributed timekeeping includes: at a node in a set of nodes in a network, at a first time, sampling two time sources and calculating a minor consensus time between the two time sources; in response to designation of the node as a leader node, accessing a second minor consensus time generated by a second node, accessing a third minor consensus time generated by a third node, calculating a first major consensus time between the first, second, and third minor consensus times, and distributing a request to validate the first major consensus time; and, based on validation of the request from a threshold quantity of nodes, cryptographically hashing a hash of a previous block and the major consensus time to generate a first block and distributing the first block to each node in the set of nodes.
    Type: Application
    Filed: July 29, 2022
    Publication date: December 8, 2022
    Inventor: Ken Yamada
  • Publication number: 20220363671
    Abstract: Described herein are glue degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment or prevention of conditions, diseases, and disorders mediated by various target proteins.
    Type: Application
    Filed: September 16, 2020
    Publication date: November 17, 2022
    Inventors: Jake AXFORD, Rohan Eric John BECKWITH, Simone BONAZZI, Nicole BUSCHMANN, Artiom CERNIJENKO, Janetta DEWHURST, Aleem FAZAL, Matthew James HESSE, Lauren HOLDER, Viktor HORNAK, Hidetomo IMASE, Rama JAIN, Xianming JIN, John Ryan KERRIGAN, Julie LACHAL, Fupeng MA, Hasnain Ahmed MALIK, James R. MANNING, Daniel MCKAY, Robert Joseph MOREAU, Pierre NIMSGERN, Gary O'BRIEN, Anna VULPETTI, Ken YAMADA, Junping ZHAO