Patents by Inventor Kendrick Turner

Kendrick Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single-domain antibody fusion proteins with the acid tail of alpha-synuclein
    Patent number: 10611809
    Abstract: A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: April 7, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Nucleic acids for single-domain antibodies with thermal stability under cytoplasmic expression
    Patent number: 10577401
    Abstract: A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: March 3, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Single-Domain Antibody Fusion Proteins with the Acid Tail of Alpha-Synuclein
    Publication number: 20190211068
    Abstract: A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 11, 2019
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Nucleic Acids for Single-Domain Antibodies with Thermal Stability Under Cytoplasmic Expression
    Publication number: 20190211069
    Abstract: A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 11, 2019
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Single-domain antibodies with improved thermal stability under cytoplasmic expression
    Patent number: 10294283
    Abstract: Methods of producing a single-domain antibody (sdAb) include causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein; and then purifying the sdAb, wherein the fusion protein is expressed free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: May 21, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Enzyme/Protein Packaged Bacterial Vesicles for Therapeutic Delivery
    Publication number: 20160222372
    Abstract: A method of producing a protein includes providing a bacterial cell expressing both (a) a protein of interest fused to one of the SpyTag/SpyCatcher pair and (b) an outer membrane protein fused to the other of the SpyTag/SpyCatcher pair; causing the bacterial cell to express both of the protein of interest fusion and the outer membrane protein fusion in outer membrane vesicles; and purifying the outer membrane vesicles.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Inventors: Scott Walper, Nathan Alves, Kendrick Turner, Igor L. Medintz, George P. Anderson
  • Single-Domain Antibodies with Improved Thermal Stability Under Cytoplasmic Expression
    Publication number: 20150203548
    Abstract: Methods of producing a single-domain antibody (sdAb) include causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein; and then purifying the sdAb, wherein the fusion protein is expressed free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: January 17, 2014
    Publication date: July 23, 2015
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Polypeptides, systems, and methods useful for detecting glucose
    Patent number: 8465981
    Abstract: The presently-disclosed subject matter provides biosensors for detecting molecules of interest. The biosensors include a polypeptide capable of selectively-binding glucose, wherein the polypeptide molecule is selected from: an unnatural analogue of wild type glucose binding protein; a fragment of wild type glucose binding protein; and an unnatural analogue fragment of wild type glucose binding protein.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: June 18, 2013
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvia Daunert, Kendrick Turner, Smita Joel, Laura Rowe
  • POLYPEPTIDES, SYSTEMS, AND METHODS USEFUL FOR DETECTING GLUCOSE
    Publication number: 20110117661
    Abstract: The presently-disclosed subject matter provides biosensors for detecting molecules of interest. The biosensors comprise a polypeptide capable of selectively-binding glucose, wherein the polypeptide molecule is selected from: an unnatural analogue of wild type glucose binding protein; a fragment of wild type glucose binding protein; and an unnatural analogue fragment of wild type glucose binding protein.
    Type: Application
    Filed: August 6, 2008
    Publication date: May 19, 2011
    Inventors: Sylvia Daunert, Kendrick Turner, Smita Joel, Laura Rowe