Abstract: An artificial bone plate unit and an assembleable artificial bone plate are provided. The artificial bone plate unit includes a plate body, multiple connecting pins, connecting holes, drug cavities, and drug-releasing openings. The plate body has two main surfaces and a peripheral surface connected between the two main surfaces. The connecting pins and the connecting holes are formed on the plate body and arranged along the peripheral surface on the plate body. The connecting holes correspond in shape to the connecting pins. The drug cavities are formed in the artificial bone plate unit and are connected to the drug-releasing openings. The artificial bone plate units are connected using the connecting pins and the connecting holes to form the assembleable artificial bone plate. The assembleable artificial bone plate can be bent into the shape of a defect area of the skull, which saves material and time.

Abstract: A mesenchymal stem cell culture product and a method for preparing the same are provided. The method for preparing the mesenchymal stem cell culture product includes the following steps. A predetermined quantity of mesenchymal stem cells is seeded in a flat culture device containing a first cell culture medium. When the mesenchymal stem cells proliferate to a target quantity, the first cell culture medium is replaced with a second cell culture medium, and the second cell culture medium is removed after incubation for 18 to 30 hours. A target cell culture medium is added and incubated for 48 to 72 hours. The target cell culture medium is collected repeatedly. The collected target cell culture medium is filtered and concentrated to obtain the mesenchymal stem cell culture product.

Abstract: A medicament delivery tooth covering is provided. The medicament delivery tooth covering includes a tooth covering and a carrier layer. The tooth covering has at least one attachment surface that covers a surface of teeth of a user. The carrier layer is arranged on the at least one attachment surface. The carrier layer carries a medicament, and the medicament contains powder particles. When water is introduced to an inner side of the at least one attachment surface of the tooth covering, the water is allowed to pass through the carrier layer, so that the medicament contacts the water. The powder particles are dual-structured powder particles that have a core structure and an outer layer structure that encloses an outer side of the core structure.

Abstract: A calcium phosphate-based core-shell structured material, a method for preparing the same, and an oral care composition using the same are provided. The calcium phosphate-based core-shell structured material includes an amorphous calcium phosphate (ACP) core and a ?-tricalcium phosphate (?-TCP) shell covering the core. The method includes a first sintering step and a second sintering step. The first sintering step is to sinter an ACP material at between 700° C. and 800° C. to obtain an ?-TCP shell. The second sintering step allows the ?-TCP shell to form into the ?-TCP shell by sintering at between 800° C. and 900° C. The oral care composition includes a calcium phosphate mixture and an orally receivable carrier. The calcium phosphate mixture includes a powder of the calcium phosphate-based core-shell structured material and a tricalcium phosphate powder mixed in a weight ratio from 3:5 to 3:7.

Abstract: A cell culture auxiliary agent and a cell culture medium using the same are provided. The cell culture auxiliary agent is formed by attaching each coordination peptide having cell affinity to two side ends of a polyoxyethylene polyoxypropylene ether block copolymer through anhydride monomers.

Abstract: An artificial bone plate unit and an assemblable artificial bone plate are provided. The artificial bone plate unit includes a plate body, multiple connecting pins and multiple connecting holes. The plate body has two main surfaces and a peripheral surface. The peripheral surface is connected between the two main surfaces. The connecting pins and the connecting holes are formed on the plate body and along the peripheral surface on the plate body. The connecting holes correspond in shape to the connecting pins. The assemblable artificial bone plate is bendable and includes multiple artificial bone plate units. The artificial bone plate units are connected using the connecting pins and the connecting holes. The assemblable artificial bone plate is assembled from artificial bone plate units and then bent into the shape of the defect area of the skull, which saves material and time.

Abstract: The present invention discloses a method for culturing human limbal stem cells comprising the steps of: pre-treating a feeder cell; seeding the feeder cells in a porous membrane; placing the porous membrane in a container to separate the container into a first cell culture compartment and a second cell culture compartment, wherein the feeder cells are located in the second cell culture compartment; injecting the culture medium into the container; and placing the human limbal stem cells in the first cell culture compartment. Compared to the prior art, the method for culturing human limbal stem cells of the present invention utilizes the porous membrane to culture the human limbal stem cells to make the expansion rate better than the traditional culture method. In addition, the culture medium used in the present invention does not contain the dimethyl sulfoxide (DMSO) with cytotoxicity to reduce the probability of cell death.

Abstract: The present invention discloses a method for producing the alpha-calcium sulfate hemihydrate bone graft, which comprises the following steps: mixing calcium sulfate dihydrate and deionized water to produce calcium sulfate dihydrate paste; stirring and heating the calcium sulfate dihydrate paste at least 160° C. within 100-350 psi to produce the conversion calcium sulfate hemihydrate, filtering the conversion calcium sulfate hemihydrate with high temperature to produce the filtered calcium sulfate hemihydrate, and washing the filtered calcium sulfate hemihydrate by absolute alcohol to get the alpha-calcium sulfate hemihydrate bone graft. The present invention does not use any catalyst, possesses a high purity, high mechanical strength, and good biocompatibility, facilitates bone growth and angiogenesis, requires only 31° C., the highest temperature, during the curing process. It makes the present invention more secure in the biomedical applications.

Abstract: A system for online monitoring powder-based 3D printing processes and method thereof are disclosed. A uniform light source having a single wavelength provided by the system is irradiated onto the powder layer before and after applied with glue. Intensities of such reflected images are obtained and subtracted from each other in an image process procedure. A difference obtained through the subtraction is compared with an original 3D model in a computer. If any defect is found such as being larger than a threshold value, the powder-based 3D printing processes will be terminated. Therefore, the technical effects of online printing processes monitoring, time saving and printing resources saving will be achieved.

Abstract: The present invention provides an ancillary additive manufacturing system for manufacturing a reconstructed model simultaneously during the oral surgery to effectively reduce the time and healthcare human resources for the oral surgery. The ancillary additive manufacturing system comprises an input device and a printing body. The printing body is connected to the input device and comprises a base, an ink-manufacturing module, an inkjet head controlling unit, and multiple inkjet heads. The ink-manufacturing module is located above the base and comprises first, second, and third ink-manufacturing units. The inkjet head controlling unit is located above the base. The inkjet heads are mounted to the inkjet head controlling unit and point toward the base and comprise a first, second, and third inkjet head. The first, second, and third inkjet head correspondingly connected to the first, second, and third ink-manufacturing units.

Abstract: The present invention discloses a method for three dimensional printing artificial skin. The method comprises the following steps of: printing a dermis layer by a hydrogel combined with an autologous dermal cell and; printing an epidermis layer on the dermis layer by a hydrogel combined with an autologous kerationocytes cell; implanting a plurality of progenitor cells for sweat glands and hair follicles through the epidermis layer into the dermis layer to form an artificial skin. Because all used materials are from the autologous skin, and the 3D printing technology is used to implant the progenitor cells for sweat glands and hair follicles to form the artificial skin which has sweat glands and hair follicles, the present invention can get an artificial skin with a complete skin structure.

Abstract: The present invention discloses an autologous cell multidimensional molding apparatus, which can customize an artificial implant by using an autologous cell. The autologous cell multidimensional molding apparatus comprises a barotropic room, an autologous cell culturing module, a supplying module, a multi-axis molding module, and an implant saving module. The autologous cell culturing module cultivates the autologous cells and sends the autologous cells to the supplying module to mix with polymer materials to be combined autologous cells. The multi-axis molding module prints the combined autologous cells to be artificial implants for carrying and saving the combined autologous cells by the implant saving module. Wherein, the barotropic room is filled with a gas having pressure greater than an ambient pressure. The modules listed above are all inside the barotropic room and connected by closed pipes.

Abstract: A bipolar electrosurgical instrument has a handle and an operation tool. The operation tool is mounted on a front end of the handle and has multiple holes densely formed in and spread over at least one working surface of the operation tool. With the multiple holes formed on the at least one working surface of the operation tool, tissues of a surgical site can be heated uniformly and adhesion of the surgical site is minimized. Moreover, since the multiple holes are directly formed on the at least one working surface, the multiple holes do not become shallow under long-term use and no toxic gas would be released when the operation tool is heated to high temperature. Accordingly, anti-adhesion effect of the operation tool and health of medical staffs can be assured.

Abstract: A bone repairing material comprises a composition including an ?-calcium sulfate hemihydrate and an autologous bone powder, wherein the bone repairing material contains 20˜60 weight percent of the autologous bone powder and 40˜80 weight percent of the ?-calcium sulfate hemihydrate. The bone repairing material has a particle size in the range of 50˜1,000 ?m. A method for producing the bone repairing material comprises the following steps: producing the ?-calcium sulfate hemihydrate from a calcium sulfate dihydrate by microwave heating; grinding an autologous bone for generating the autologous bone powder; and, mixing the ?-calcium sulfate hemihydrate and the autologous bone powder to form the bone repairing material.

Abstract: The present invention discloses a method for producing the alpha-calcium sulfate hemihydrate bone graft, which comprises the following steps: mixing calcium sulfate dihydrate and deionized water to produce calcium sulfate dihydrate paste; stirring and heating the calcium sulfate dihydrate paste at least 160° C. within 100-350 psi to produce the conversion calcium sulfate hemihydrate, filtering the conversion calcium sulfate hemihydrate with high temperature to produce the filtered calcium sulfate hemihydrate, and washing the filtered calcium sulfate hemihydrate by absolute alcohol to get the alpha-calcium sulfate hemihydrate bone graft. The present invention does not use any catalyst, possesses a high purity, high mechanical strength, and good biocompatibility, facilitates bone growth and angiogenesis, requires only 31° C., the highest temperature, during the curing process. It makes the present invention more secure in the biomedical applications.

Abstract: The present disclosure relates to a prosthesis for dental replacement, the prosthesis includes a root. The root includes an abutment and a base portion. The abutment is adapted for affixation of a dental crown thereto. The base portion is shaped for insertion into a tooth socket. The base portion includes a core, a metallic oxide layer on the core and a film-like stem cell layer on the metallic oxide layer. The metallic oxide layer has a number of holes.

Abstract: A method for reversed modeling of biomedical model of the present invention comprises at least the following steps: (a) Obtaining the data of a first model; (b) Transferring data of the first model into data of a second model which are applied to a rapid Prototyping machine; (c) Entering data of the second model into the rapid prototyping machine; (d) Laying model materials, coating adhesives and continuing sterilization by the rapid prototyping machine and stacking until a biomedical model is made; wherein sterilization is done during stacking medical model, therefore keeping the biomedical model sterile inside is achieved.

Abstract: The invention provides a method for promoting wound healing or tissue injury treatment in a subject in need thereof, the method comprising administering to the subject an effective amount of one or more fungal immunomodulatory protein (preferably, Ganoderma immunomodulatory protein).

Abstract: Provided is a sustained drug-releasing artificial dental crown having a drug container, a drug-supplying microfluidic channel, and a drug-releasing microfluidic channel in the crown body. Medications can be added into the drug container through the drug-supplying microfluidic channel. The medications housed in the drug container can be released to the dental caries slowly and continuously over an extended period through the drug-releasing microfluidic channel. The sustained drug-releasing artificial dental crown provides a crown body to cap the dental caries or dental implant post to treat the dental disease or to wash the dental implant post for a prolonged time. In addition, the medications can be locally deposited on the affected areas by the sustained drug-releasing artificial dental crown. The sustained drug-releasing artificial dental crown can help to reduce the dosage of medications to attain the estimated efficacy and to prevent the side effects by oral administration.

Abstract: A method for preparing artificial vessels comprises preparing a template by 3D printing; preparing an active polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (active POSS-PCU); mixing the active POSS-PCU with stem cells to form the artificial vessels by 3D printing followed by plasma processing; removing the template to form the artificial blood vessels with an access. The method provides to prepare the artificial vessels with three-layer structures, which are capable of transporting nutrients and oxygen, removing metabolic wastes and enhancing haemocompatibility and biological stability. Therefore, the method for preparing the artificial vessels solves the problem of angiemphraxis caused by the artificial vessels with single-layer structure.