Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: A focusing apparatus includes a determination unit configured to determine whether an object is a moving object, and a focusing unit configured to perform focusing using information on driving of the focus lens generated based on the focus detecting signal in response to an operation of an operation unit. The determination unit determines whether the object is the moving object, using a first threshold before the operation of the operation unit, and using a second threshold different from the first threshold after the operation of the operation unit. The focusing unit performs first focusing that continuously performs the focusing when the determination unit determines that the object is the moving object before the operation of the operation unit, and performs the first focusing when the determination unit determines that the object is the moving object after performing second focusing that performs the focusing once.

Abstract: A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an NTRK3 fusion protein, or a fusion gene encoding the fusion protein, or an ETV6 fusion protein, or a fusion gene encoding the fusion protein, in a sample derived from the digestive system obtained from a subject, is detected.

Abstract: A controller provided at an information processing apparatus is configured to acquire information indicating driving history regarding traveling of a vehicle, specify a traveling section having a distance equal to or longer than a predetermined distance, in which the vehicle repeatedly travels at a frequency equal to or higher than a predetermined frequency, on the basis of the information indicating the driving history, and send a notification to a driver of the vehicle for encouraging the driver to provide ride sharing using the vehicle in the specified traveling section.

Abstract: A controller provided at an information processing apparatus is configured to acquire information indicating driving history regarding traveling of a vehicle, specify a traveling section having a distance equal to or longer than a predetermined distance, in which the vehicle repeatedly travels at a frequency equal to or higher than a predetermined frequency, on the basis of the information indicating the driving history, and send a notification to a driver of the vehicle for encouraging the driver to provide ride sharing using the vehicle in the specified traveling section.

Abstract: An object of the present invention is to provide an effective method of predicting an effect of treatment by a PD-1/PD-L1 blockade, which is a method of predicting whether or not PD-1/PD-L1 blockade is effective for treatment of a subject suffering from a malignant tumor, which comprises detecting abnormality of genome relating to effectiveness of the PD-1/PD-L1 blockade in a tumor cell taken from the subject and evaluating the PD-1/PD-L1 blockade as useful for the treatment of the subject when there is the abnormality.

Abstract: An information processing apparatus includes a processor which executes accepting purchase of a ticket for an event from a first ticket purchaser and, if the first ticket purchaser is to travel to a venue for the event by a vehicle, accepting registration of information on a ride-sharing usage pattern, selecting, as a ride-sharing candidate, a second ticket purchaser which conforms to the ride-sharing usage pattern for the first ticket purchaser from among ticket purchasers which have purchased tickets for the event or a similar event partially identical in venue and period to the event, and presenting the second ticket purchaser to the first ticket purchaser.

Abstract: A processor provided in an information processing apparatus is configured to acquire trip information about trips of a plurality of vehicles in a predetermined region, specify, among the trips of the plurality of vehicles, based on the trip information, a trip with respect to which a travel route of a first vehicle includes a departure point and an arrival point of a travel route of a second vehicle, and generate information indicating an effect of ride-sharing on traffic by assuming establishment of ride-sharing in the first vehicle for the trip that is specified.

Abstract: An information processing device includes a processor configured to detect whether or not a vehicle that is about to use a facility is under share ride by a plurality of persons, and permit the vehicle to use the facility or providing an economic merit associated with usage of the facility to the vehicle, when having detected that the vehicle is under share ride.

Abstract: A controller provided at an information processing apparatus is configured to acquire information indicating driving history regarding traveling of a vehicle, specify a traveling section having a distance equal to or longer than a predetermined distance, in which the vehicle repeatedly travels at a frequency equal to or higher than a predetermined frequency, on the basis of the information indicating the driving history, and send a notification to a driver of the vehicle for encouraging the driver to provide ride sharing using the vehicle in the specified traveling section.

Abstract: The present invention relates to a protein composition formed of dry matter of a dispersion in which a protein is dispersed in a stabilizer solution, in which the stabilizer includes at least one type selected from the group consisting of a catechol-based stabilizer, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 2,6-di-tert-butyl-p-cresol, 2-tert-butyl-4-methoxyphenol, and 6,6?-di-tert-butyl-4,4?-butylidenedi-m-cresol.

Abstract: A control apparatus includes a focus detector configured to perform a focus detection by a phase difference method based on an image signal output from an image sensor, a driver configured to change a relative position between an imaging optical system and the image sensor in a direction orthogonal to an optical axis in the imaging optical system, and a controller configured to control the focus detector and the driver so as to perform the focus detection by changing the relative position between the imaging optical system and the image sensor to each of a first position and a second position.

Abstract: The focus detection apparatus includes circuitry which function as a producer configured to acquire paired phase difference image signals that are produced through photoelectric conversion of an object image formed by an optical system including a focus lens and that have therebetween a phase difference corresponding to a focus state of the object image, and configured to produce focus detection information using the phase difference acquired from the paired phase difference image signals, and an acquirer configured to acquire a feature value relating to a correlation value between the paired phase difference image signals. The producer is configured to acquire the phase difference depending on a result of comparison between the feature values acquired before and after driving of the focus lens.

Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: The diagnostic markers that provide novel diagnostic criteria to blastic plasmacytoid dendritic cell neoplasm (BPDCN) has been searched, and the presence of immunoblastoid cytomorphology, 8q24 rearrangement, and MYC expression were established as novel markers for subtyping BPDCN. It has been further found that the inhibitors which directly or indirectly inhibit the expression, functions, or signaling pathways of MYC, such as BET bromodomain-selective inhibitors or aurora kinase inhibitors, are effective in MYC-positive BPDCN, and HDAC inhibitors or BCL2 family protein inhibitors are effective as therapeutic drugs for BPDCN.

Abstract: A gas sensor includes a sensor element that includes a gas inlet through which a measurement target gas is introduced into the sensor element and a protective cover that contains a substance having a capability of decomposing ammonia. The protective cover has a gas-contact surface area within a range of 450 mm2 to 1145 mm2, the gas-contact surface area being a sum of a surface area of a portion facing the inlet-side gas flow path and a surface area of a portion facing an in-element-chamber flow path of the sensor element chamber that is a shortest flow path for the measurement target gas from the element-chamber inlet to the gas inlet.

Abstract: A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an FGFR3 fusion protein, or a fusion gene encoding the fusion protein, or a TACC3 fusion protein, or a fusion gene encoding the fusion protein, is detected in a sample derived from female genitalia obtained from a subject.

Abstract: An object of the present invention is to provide an effective method of predicting an effect of treatment by a PD-1/PD-L1 blockade, which is a method of predicting whether or not PD-1/PD-L1 blockade is effective for treatment of a subject suffering from a malignant tumor, which comprises detecting abnormality of genome relating to effectiveness of the PD-1/PD-L1 blockade in a tumor cell taken from the subject and evaluating the PD-1/PD-L1 blockade as useful for the treatment of the subject when there is the abnormality.

Abstract: A focus detection apparatus comprises an image capturing unit including a plurality of pixels for detecting a pair of image signals of an object, a setting unit which sets, in the image capturing unit, focus detection areas in which pixel lines including a plurality of pixels aligned in a first direction are arranged in a second direction perpendicular to the first direction, a signal generation unit which generates the pair of image signals from outputs of the pixel lines of the focus detection areas, and a focus detection unit which determines an amount of defocus of an imaging optical system by using the pair of image signals. The setting unit is configured to arrange the pixel lines such that the pixel lines are out of phase between adjacent focus detection areas.

Abstract: The focus detection apparatus includes circuitry which function as a producer configured to acquire paired phase difference image signals that are produced through photoelectric conversion of an object image formed by an optical system including a focus lens and that have therebetween a phase difference corresponding to a focus state of the object image, and configured to produce focus detection information using the phase difference acquired from the paired phase difference image signals, and an acquirer configured to acquire a feature value relating to a correlation value between the paired phase difference image signals. The producer is configured to acquire the phase difference depending on a result of comparison between the feature values acquired before and after driving of the focus lens.