Abstract: Systems and methods for multi-modal imaging using an endoscope having an instrument channel, where the imaging is achieved without using the channel, are disclosed. The systems can include a multi-modal imaging paddle housing couple to a distal end of the endoscope. The housing can receive at least two imaging probes. The imaging probes can be an angle-resolved low-coherence interferometry probe (a/LCI) and an optical coherence tomography (OCT) probe. The housing can be scaled and positioned to be visible via the endoscope camera. The system and method can include locating the housing in a region of interest using the endoscope camera, acquiring OCT measurements to identify targets, and then acquiring a/LCI measurements at the identified targets.

Abstract: Methods, apparatus and devices for providing images based on the optical phase gradients within a biological sample can be provided. In one exemplary embodiment, a tethered and/or untethered capsule can be introduced into a biological specimen to acquire images by illuminating the specimen from at least two different angles, while an objective lens arrangement can relay an image from the illuminated sample to an imaging sensor array. The difference between images acquired using differing illumination angles and from the same position in the sample can indicate a phase contrast in a certain technique (e.g., oblique back illumination). The image focal plane provided by this exemplary arrangement/device, e.g., being planar by definition, constitutes only a small fraction of a volumetric specimen. To provide, e.g.