Abstract: Systems and methods for a tethered optical imaging probe configured to be integrated into an optical system for medical diagnosis are provided. In one configuration, the present disclosure provides a tethered optical imaging probe including a motor arranged within a swallowable capsule. A rotational speed of the motor is actively controlled by a feedback signal.

Abstract: Exemplary apparatus and method are provided for illuminating a sample. With such exemplary apparatus and/or method, it is possible to, using at least one source arrangement, provide at least one first electro-magnetic radiation. Using an optical system of an optics arrangement, it is possible to receive the first electro-magnetic radiation(s), and modifying the at least one first electro-magnetic radiation to be at least one second electro-magnetic radiation so as to be forwarded to the sample. Further, with the optical system, it is possible to extend the at least one second electro-magnetic radiation into or across the sample for a distance of at least 2 times the Raleigh range of a Gaussian beam when the optics arrangement and the sample are stationary with respect to one another. Additionally, using the optical system, it is possible to control a placement of a focus of the at least one second electro-magnetic radiation on or in the sample.

Abstract: Exemplary apparatus and method are provided for illuminating a sample. With such exemplary apparatus and/or method, it is possible to, using at least one source arrangement, provide at least one first electro-magnetic radiation. Using an optical system of an optics arrangement, it is possible to receive the first electro-magnetic radiation(s), and modifying the at least one first electro-magnetic radiation to be at least one second electro-magnetic radiation so as to be forwarded to the sample. Further, with the optical system, it is possible to extend the at least one second electro-magnetic radiation into or across the sample for a distance of at least 2 times the Raleigh range of a Gaussian beam when the optics arrangement and the sample are stationary with respect to one another. Additionally, using the optical system, it is possible to control a placement of a focus of the at least one second electro-magnetic radiation on or in the sample.

Abstract: Exemplary apparatus and method are provided for illuminating a sample. With such exemplary apparatus and/or method, it is possible to, using at least one source arrangement, provide at least one first electro-magnetic radiation. Using an optical system of an optics arrangement, it is possible to receive the first electro-magnetic radiation(s), and modifying the at least one first electro-magnetic radiation to be at least one second electro-magnetic radiation so as to be forwarded to the sample. Further, with the optical system, it is possible to extend the at least one second electro-magnetic radiation into or across the sample for a distance of at least 2 times the Raleigh range of a Gaussian beam when the optics arrangement and the sample are stationary with respect to one another. Additionally, using the optical system, it is possible to control a placement of a focus of the at least one second electro-magnetic radiation on or in the sample.

Abstract: Optics for apodizing an optical imaging probe beam, and methods for fabricating optics for apodizing an optical imaging probe beam are provided. In some embodiments, optics for apodizing an electrical comprises: an optical fiber; a focusing element coaxially aligned with the optical fiber; an element having a cylindrical bore and an angled reflective surface, wherein a first portion of a beam focused by the focusing element enters the cylindrical bore and a second portion of the beam is reflected at an angle to produce a beam with a generally annular-shaped profile.

Abstract: Exemplary apparatus and method are provided for illuminating a sample. With such exemplary apparatus and/or method, it is possible to, using at least one source arrangement, provide at least one first electro-magnetic radiation. Using an optical system of an optics arrangement, it is possible to receive the first electro-magnetic radiation(s), and modifying the at least one first electro-magnetic radiation to be at least one second electro-magnetic radiation so as to be forwarded to the sample. Further, with the optical system, it is possible to extend the at least one second electro-magnetic radiation into or across the sample for a distance of at least 2 times the Raleigh range of a Gaussian beam when the optics arrangement and the sample are stationary with respect to one another. Additionally, using the optical system, it is possible to control a placement of a focus of the at least one second electro-magnetic radiation on or in the sample.

Abstract: Optics for apodizing an optical imaging probe beam, and methods for fabricating optics for apodizing an optical imaging probe beam are provided. In some embodiments, optics for apodizing an electrical comprises: an optical fiber; a focusing element coaxially aligned with the optical fiber; an element having a cylindrical bore and an angled reflective surface, wherein a first portion of a beam focused by the focusing element enters the cylindrical bore and a second portion of the beam is reflected at an angle to produce a beam with a generally annular-shaped profile.

Abstract: Systems and methods for a tethered optical imaging probe configured to be integrated into an optical system for medical diagnosis are provided. In one configuration, the present disclosure provides a tethered optical imaging probe including a motor arranged within a swallowable capsule. A rotational speed of the motor is actively controlled by a feedback signal.

Abstract: A first image data set of the real-world object is received at a processor where the real-world object was illuminated with substantially uniform illumination. A second image data set of the real-world object is received at the processor where the real-world object was illuminated with substantially structured illumination. A high pass filter is applied to the first-image data set to remove out-of-focus content and retrieve high-frequency in-focus content. The local contrast of the second-image data set is determined producing a low resolution local contrast data set. The local contrast provides a low resolution estimate of the in-focus content in the first-image data set. A low pass filter is applied to the estimated low resolution in-focus data set, thus making its frequency information complementary to the high-frequency in-focus data set. The low and high frequency in-focus data sets are combined to produce an optically-sectioned data set of the real-world object.

Abstract: A first image data set of the real-world object is received at a processor where the real-world object was illuminated with substantially uniform illumination. A second image data set of the real-world object is received at the processor where the real-world object was illuminated with substantially structured illumination. A high pass filter is applied to the first-image data set to remove out-of-focus content and retrieve high-frequency in-focus content. The local contrast of the second-image data set is determined producing a low resolution local contrast data set. The local contrast provides a low resolution estimate of the in-focus content in the first-image data set. A low pass filter is applied to the estimated low resolution in-focus data set, thus making its frequency information complementary to the high-frequency in-focus data set. The low and high frequency in-focus data sets are combined to produce an optically-sectioned data set of the real-world object.