Abstract: The present disclosure provides, for example, a method of stabilizing the RAF/MEK complex in a subject, the method comprising administering to the subject an effective amount of a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or —N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group.

Abstract: A hollow metal part is used as a pipe component for a refrigerant flow path of a rotating electrical machine adapted to cool a stator coil with a refrigerant. The rotating electrical machine includes a connection arm that couples the stator coil and a power supply terminal at a stator coil end portion of the stator coil, and an insulating hose that is coupled to the stator coil and the connection arm through a first hollow metal part in order to supply the refrigerant to the stator coil and the connection arm. The first hollow metal part is formed integrally by joining a part formed of stainless steel to a part made of oxygen-free copper.

Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60 wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.

Abstract: A hydro dynamic bearing device comprising an upper half of a main bearing and a lower half of the main bearing, wherein the upper half of the main bearing is lined with a low-strength metal such as a Babbitt metal, wherein a circumferential groove is formed in the lower half of the main bearing, and wherein the low-strength metal of the upper half of the main bearing, which is formed at a region opposed to a downstream side of the circumferential groove formed in the lower half of the main bearing, is partially removed to cause a high-strength bearing base metal to be partially exposed.

Abstract: The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

Abstract: A hollow metal part is used as a pipe component for a refrigerant flow path of a rotating electrical machine adapted to cool a stator coil with a refrigerant. The rotating electrical machine includes a connection arm that couples the stator coil and a power supply terminal at a stator coil end portion of the stator coil, and an insulating hose that is coupled to the stator coil and the connection arm through a first hollow metal part in order to supply the refrigerant to the stator coil and the connection arm. The first hollow metal part is formed integrally by joining a part formed of stainless steel to a part made of oxygen-free copper.

Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60 wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.

Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.

Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.

Abstract: A hydro dynamic bearing device comprising an upper half of a main bearing and a lower half of the main bearing, wherein the upper half of the main bearing is lined with a low-strength metal such as a Babbitt metal, wherein a circumferential groove is formed in the lower half of the main bearing, and wherein the low-strength metal of the upper half of the main bearing, which is formed at a region opposed to a downstream side of the circumferential groove formed in the lower half of the main bearing, is partially removed to cause a high-strength bearing base metal to be partially exposed.

Abstract: A hydro dynamic bearing device comprising an upper half of a main bearing and a lower half of the main bearing, wherein the upper half of the main bearing is lined with a low-strength metal such as a Babbitt metal, wherein a circumferential groove is formed in the lower half of the main bearing, and wherein the low-strength metal of the upper half of the main bearing, which is formed at a region opposed to a downstream side of the circumferential groove formed in the lower half of the main bearing, is partially removed to cause a high-strength bearing base metal to be partially exposed.

Abstract: In an electrical machinery and apparatus, a storage space is formed along an extension direction of a strand, and a temperature sensor is installed in the storage space of the strand, so that temperature of the strand can be immediately measured, and no pressure is applied to the temperature sensor in the process of forming a ground wall insulation thereby the temperature of the strand can be accurately measured.

Abstract: The present invention provides a method and a system for providing an energy creation service of a turbine generator. The users can receive a desired energy creation service without any initial investment and the providers of the service can expect sufficient profits. The method includes the steps of installing a new turbine generator for a user owning a power-generating facility having a turbine generator; obtaining power generation efficiency of the new turbine generator by a monitoring device; comparing the power generation efficiency of the new turbine generator and power generation efficiency of a turbine generator predetermined as a standard, by a computing device; performing a charging process for an excess of the power generation efficiency of the new turbine generator over the power generation efficiency of the standard turbine generator, by a processing device; and charging the user for a price reflecting the excess of the power generation efficiency.

Abstract: The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

Abstract: A hydro dynamic bearing device comprising an upper half of a main bearing and a lower half of the main bearing, wherein the upper half of the main bearing is lined with a low-strength metal such as a Babbitt metal, wherein a circumferential groove is formed in the lower half of the main bearing, and wherein the low-strength metal of the upper half of the main bearing, which is formed at a region opposed to a downstream side of the circumferential groove formed in the lower half of the main bearing, is partially removed to cause a high-strength bearing base metal to be partially exposed.

Abstract: A horizontal shaft type rotary machine capable of simply feeding oil into thrust bearing devices. Leak oil introduction is provided in the circumferential end parts of thrust bearing devices, for introducing leak oil of lubrication oil from horizontal type slide bearing devices onto slide surfaces of the thrust bearing devices. With this configuration, the thrust baring devices can be lubricated with the use of leak oil of lubrication oil from the horizontal type slide bearing devices, and as a result, it is possible to eliminate the necessity of an oil feed system exclusively used for the thrust bearing devices, thereby it is possible to simplify the pipe line arrangement of the oil feed system and the control of oil feed quantity.

Abstract: An electrical rotating machine including a stator core is provided. The stator core is formed of substantially sector-shaped sheet segments die-cut from electrical steel sheets and arranged in a circumferential direction of the stator core to form circular sheets which are stacked in an axial direction of the stator core. In the electrical rotating machine, end regions of the stator core are formed of stacked sheet segments die-cut from non-grain oriented steel sheets, and the other region of the stator core is formed of stacked sheet segments die-cut from grain oriented steel sheets.

Abstract: An external patch containing diclofenac hydroxyethylpyrrolidine prepared by laminating an adhesive layer on a backing, wherein said adhesive layer is characterized by comprising 5-50% by weight of styrene•isoprene•styrene block copolymer, 20-50% by weight of a tackifier resin, 5-70% by weight of a softening agent, and 0.5-20% by weight of one or more solubilizers selected from N-methyl-2-pyrrolidone, propylene glycol and dimethyl sulfoxide as essential ingredients, and 0.5-20% by weight of diclofenac hydroxyethylpyrrolidine as an active ingredient. The patch has excellent transdermal absorption, less skin-irritation and excellent stability of the drug.