Patents by Inventor Kenichi Imaizumi

Kenichi Imaizumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUINAZOLINE COMPOUND FOR INDUCING DEGRADATION OF G12D MUTANT KRAS PROTEIN
    Publication number: 20240182483
    Abstract: [Problem] To provide a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. [Means for resolution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a quinazoline compound has an excellent degradation-inducing action on a G12D mutant KRAS protein and a G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The quinazoline compound or a salt thereof of the present invention can be used as a therapeutic agent for pancreatic cancer.
    Type: Application
    Filed: February 14, 2022
    Publication date: June 6, 2024
    Inventors: Tomohiro YOSHINARI, Hiroki ISHIOKA, Eiji KAWAMINAMI, Hideyuki WATANABE, Kenichi KAWAGUCHI, Kazuyuki KURAMOTO, Tomoyoshi IMAIZUMI, Takahiro MORIKAWA, Hisao HAMAGUCHI, Sunao IMADA, Mitsuaki OKUMURA, Takeyuki NAGASHIMA, Kohei INAMURA
  • 4-AMINOQUINAZOLINE COMPOUND
    Publication number: 20240150366
    Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 9, 2024
    Inventors: Kenichi KAWAGUCHI, Kazuyuki KURAMOTO, Tomoyoshi IMAIZUMI, Takahiro MORIKAWA, Mitsuaki OKUMURA, Sunao IMADA, Eiji KAWAMINAMI, Ryo SATO, Yohei SEKI, Hisao HAMAGUCHI, Hiroki ISHIOKA, Hiroki FUKUDOME, Ikumi KURIWAKI, Takeyuki NAGASHIMA
  • Rotary piston internal combustion engine
    Patent number: 3964446
    Abstract: The inner peripheral wall of a rotary engine housing is provided with first and second port means which open into a combustion chamber of the engine as the apex seals of the rotor pass the port means in timed relationship. The first port means introduce an air-fuel mixture and the second port means, which are spaced from the first port means forwardly in the direction of rotor rotation subsequently introduce air into the chamber. Thus, a stratified charge consisting of a layer of air and a denser layer of air-fuel mixture is provided within the combustion chamber.
    Type: Grant
    Filed: January 2, 1975
    Date of Patent: June 22, 1976
    Assignee: Toyota Jidosha Kogyo Kabushiki Kaisha
    Inventors: Toshiyuki Kohno, Kenichi Imaizumi