Patents by Inventor Kenichi Mochida
Kenichi Mochida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6815449Abstract: Compounds having immunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. are represented by formula I: and pharmaceutically acceptable salts thereof.Type: GrantFiled: November 7, 2002Date of Patent: November 9, 2004Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Akama, Hiroyuki Nagata, Atsuhiro Hasegawa, Harumi Ue, Isami Takahashi, Yutaka Saitoh, Kenichi Mochida, Shun-ichi Ikeda, Yutaka Kanda
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Publication number: 20030181722Abstract: Compounds having immunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc.Type: ApplicationFiled: November 7, 2002Publication date: September 25, 2003Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Akama, Hiroyuki Nagata, Atsuhiro Hasegawa, Harumi Ue, Isami Takahashi, Yutaka Saitoh, Kenichi Mochida, Shun-Ichi Ikeda, Yutaka Kanda
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Patent number: 6613774Abstract: LK6-A derivatives which have immmunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. and which are represented by general formula (I): as defined herein, and pharmaceutically acceptable salts thereof.Type: GrantFiled: January 2, 2001Date of Patent: September 2, 2003Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsutomu Akama, Hiroyuki Nagata, Atsuhiro Hasegawa, Harumi Ue, Isami Takahashi, Yutaka Saitoh, Kenichi Mochida, Shun-ichi Ikeda, Yutaka Kanda
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Patent number: 6569652Abstract: The present invention relates to a process for producing optically active diols represented by the general formula (II): wherein R1 represents (CH2)n, CH═CH, O, S or NH whereupon n is an integer of 1 to 4, and R2 represents hydrogen, C1-6 alkyl, C1-6 alkoxy, (C1-6 alkoxy)-carbonyl, hydroxy, carboxy, halogen, nitro or amino, which comprises treating compounds represented by the general formula (I): wherein R1 and R2 have the same meanings as defined above, with a culture of a microorganism belonging to the genus Rhodococcus, Bacillus, Brevibacterium or Gordona and being capable of stereoselectively diolating a double bond in ring A, or with a culture of Mortierella vinacea, or with said microorganism itself, or with a treated material from said microorganism.Type: GrantFiled: February 25, 2000Date of Patent: May 27, 2003Assignee: Merck & Co., Inc.Inventors: Tamotsu Eguchi, Hideyo Kumazawa, Kenichi Mochida
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Patent number: 6107064Abstract: The present invention relates to a process for producing a xanthine derivative represented by formula (II), comprising converting a xanthine derivative represented by formula (I) {hereinafter, referred to as Compound (I)}: ##STR1## (wherein R.sup.1 and R.sup.2 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl) into a xanthine derivative represented by formula (II) {hereinafter, referred to as Compound (II)}: ##STR2## (wherein R.sup.3 and R.sup.4 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl; R.sup.5 and R.sup.6 independently represent hydrogen, hydroxy, or oxo; with the proviso that R.sup.5 and R.sup.6 are both hydrogen, at least one of R.sup.3 and R.sup.Type: GrantFiled: January 17, 1996Date of Patent: August 22, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Junichi Shimada, Tamotsu Eguchi, Kenichi Mochida, Akira Horiguchi, Tohru Yasuzawa, Hideaki Kusaka, Hiromi Nonaka, Fumio Suzuki
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Patent number: 4929551Abstract: The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and (2) glucose and glucose dehydrogenase. L(-)-tetrahydrofolic acid is useful as the intermediate for L(-)-leucovarin.Type: GrantFiled: August 15, 1989Date of Patent: May 29, 1990Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamotsu Eguchi, Takashi Oshiro, Yukihiro Kuge, Kenichi Mochida, Takayuki Uwajima
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Patent number: 4923986Abstract: The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-ep oxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W.sub.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y represent various substituents. The compounds are physiologically active substances that inhibit protein kinase C and exhibit an antitumor activity, and are useful as medicines.Type: GrantFiled: November 8, 1988Date of Patent: May 8, 1990Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Chikara Murakata, Akira Sato, Mitsuru Takahashi, Eiji Kobayashi, Makoto Morimoto, Shiro Akinaga, Tadashi Hirata, Kenichi Mochida, Hiroshi Kase, Koji Yamada, Kazuyuki Iwashashi
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Patent number: 4760060Abstract: Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.Type: GrantFiled: November 15, 1985Date of Patent: July 26, 1988Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenichi Mochida, Takehiro Ogasa, Junichi Shimada, Tadahi Hirata, Kiyoshi Sato, Ryo Okachi
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Patent number: 4694001Abstract: .beta.-Lactam compounds represented by the general formula: ##STR1## (wherein X represents CH.sub.2, S or O; Y represents a hydroxyl group, a lower alkanoyloxy group or a lower alkoxycarbonyloxy group; W is a group represented by CH.sub.2, NH, ##STR2## A is a phenyl group, a naphthyl group, or a monocyclic or dicyclic heterocyclic group, respectively substituted by (Y).sub.n ; R.sub.4 and R.sub.5 each are a hydrogen atom, a lower alkyl group, or a cycloalkylidene group with a carbon atom combined therewith; l is 0 or an integer of 1, 2 or 3; m is 0 or 1; n is an integer of 1, 2, 3, 4 or 5; and R.sub.1, R.sub.2 and R.sub.3 are groups often used in the conventional .beta.-lactam compounds) have strong antimicrobial activities against a wide range of Gram positive and negative bacteria; particularly Gram negative bacteria including Pseudomonas aeruginosa, Pseudomonas sepatia and various Enterobacters.Type: GrantFiled: November 26, 1984Date of Patent: September 15, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tadashi Hirata, Kenichi Mochida, Chihiro Shiraki, Kiyoshi Sato
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Patent number: 4640919Abstract: Carbacephem compounds represented by the formula: ##STR1## [wherein R.sub.1 is a lower alkylsulfonyloxy, unsubstituted or substituted arylsulfonyloxy, azido, cyano, carbamoyloxy, unsubstituted or substituted heterocyclic thio ("heterocyclic" means a 5- or 6-membered heterocyclic group having 1 to 4 O, S or N atoms), unsubstituted or substituted lower alkylthio, or unsubstituted or substituted arylthio group; R.sub.2 and R.sub.3 are groups frequently used in the cephalosporin chemistry] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for curing various infections.Type: GrantFiled: February 19, 1985Date of Patent: February 3, 1987Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenichi Mochida, Takehiro Ogasa, Junichi Shimada, Tadashi Hirata, Kiyoshi Sato, Ryo Okachi
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Patent number: 4237272Abstract: Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin A.Type: GrantFiled: December 20, 1978Date of Patent: December 2, 1980Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenichi Mochida, Moriyuki Sato, Shigeo Yoshiie, Yasuki Mori
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Patent number: 4237269Abstract: Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin A.Type: GrantFiled: December 20, 1978Date of Patent: December 2, 1980Assignee: Abbott LaboratoriesInventors: Kenichi Mochida, Moriyuki Sato, Shigeo Yoshiie, Yasuki Mori
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Patent number: 4226980Abstract: Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin B.Type: GrantFiled: December 7, 1978Date of Patent: October 7, 1980Assignee: Abbott LaboratoriesInventors: Moriyuki Sato, Kenichi Mochida, Shigeo Yoshiie, Yasuki Mori
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Patent number: 4169942Abstract: 6'-N-methylfortimicin D and 6'-N-methylfortimicin KE are produced by chemically moidifying fortimicin KE. 6'-N-methylfortimicin D is useful as an antibacterial compound; and 6'-N-methylfortimicin KE is useful as an intermediate in the synthesis of the former compound.Type: GrantFiled: April 25, 1978Date of Patent: October 2, 1979Assignee: Abbott LaboratoriesInventors: Kenichi Mochida, Yasuki Mori
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Patent number: 4016186Abstract: Novel .beta.-phenoxy- or substituted phenoxy-ethanol compounds or esters thereof expressed by the formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group, R.sup.2 is a hydrogen atom or a substituent, Y is --OH group or group ##STR2## R.sup.3 is an alkyl group, and n is an integer of 1 to 3. These compounds have juvenile hormone activities, and are useful for hormonal pest control and increased production of silkworm cocoons.Type: GrantFiled: November 26, 1974Date of Patent: April 5, 1977Assignees: Kyowa Hakko Kogyo Co., Ltd., Sagami Chemical Research CenterInventors: Kiyosi Kondo, Osamu Terada, Kohei Oshima, Yasuki Mori, Kenichi Mochida