Abstract: Provided is a separator having excellent chemical resistance, impact resistance, and productivity. A bearing retainer (1) is a separator that is interposed between two spheres adjacent to and moving in conjunction with each other for retaining the spheres configured to be movable in conjunction with and apart from each other and is formed from a resin composition containing a fluororesin which is a polymer of a monomer containing vinylidene fluoride as a main component. The bending modulus of elasticity of the resin composition is 1600 MPa or less, and the Charpy impact strength of the resin composition is 26 kJ/m2 or more.

Abstract: Provided is a separator having excellent chemical resistance, impact resistance, and productivity. A bearing retainer (1) is a separator that is interposed between two spheres adjacent to and moving in conjunction with each other for retaining the spheres configured to be movable in conjunction with and apart from each other and is formed from a resin composition containing a fluororesin which is a polymer of a monomer containing vinylidene fluoride as a main component. The bending modulus of elasticity of the resin composition is 1600 MPa or less, and the Charpy impact strength of the resin composition is 26 kJ/m2 or more.

Abstract: Provided is a bearing retainer (1) which has excellent oil resistance and impact resistance. The bearing retainer (1) retains a plurality of balls in such a manner that the balls are apart from each other. In a ball screw that is provided with a first member and a second member which moves relatively to the first member, the plurality of balls is arranged on one of the first member or the second member so as to be in contact with both of the first member and the second member, and rolling of the balls enables the relative movement. This bearing retainer (1) is formed from a resin composition that contains an elastomer component and a fluororesin which is mainly composed of vinylidene fluoride.

Abstract: Provided is a bearing retainer (1) which has excellent oil resistance and impact resistance. The bearing retainer (1) retains a plurality of balls in such a manner that the balls are apart from each other. In a ball screw that is provided with a first member and a second member which moves relatively to the first member, the plurality of balls is arranged on one of the first member or the second member so as to be in contact with both of the first member and the second member, and rolling of the balls enables the relative movement. This bearing retainer (1) is formed from a resin composition that contains an elastomer component and a fluororesin which is mainly composed of vinylidene fluoride.

Abstract: Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.

Abstract: Disclosed is an antidepressant, neuroprotectant, amyloid ? deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):

Abstract: Disclosed is an antidepressant, neuroprotectant, amyloid ? deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):

Abstract: [Problem] To provide a prophylactic/therapeutic agent against, for example, nerve diseases and the like such as ischemic brain disease and neurodegenerative disease, or a prophylactic/therapeutic agent against diseases against which antioxidant action is effective, as a cell protecting agent, in particular as an inhibitor of brain cell damage or brain cell death.

Abstract: Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.

Abstract: A kit, composition, product or medicament for treating cognitive impairment is provided, which includes a therapeutic agent for neurodegenerative disease and a heterocyclic compound represented by the following General Formula (I): or a hydrate thereof, a solvate thereof or a pharmaceutically acceptable salt thereof.

Abstract: [Problem] To provide a prophylactic/therapeutic agent against, for example, nerve diseases and the like such as ischemic brain disease and neurodegenerative disease, or a prophylactic/therapeutic agent against diseases against which antioxidant action is effective, as a cell protecting agent, in particular as an inhibitor of brain cell damage or brain cell death.

Abstract: A kit, composition, product or medicament for treating cognitive impairment is provided, which includes a therapeutic agent for neurodegenerative disease and a heterocyclic compound represented by the following General Formula (I): or a hydrate thereof, a solvate thereof or a pharmaceutically acceptable salt thereof.

Abstract: Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.

Abstract: An O-aryl N-(6-alkoxy-2-pyridyl)-N-alkylthiocarbamate represented by the following formula (I): (wherein R1, R2 and Ar are as defined below) is produced by treating a phenol represented by the following general formula (IV): Ar—OH??(IV) (wherein Ar represents an aryl group) with a base in a solvent and then adding thereto an alkali metal salt of N-(6-alkoxy-2-pyridyl)-N-alkyldithiocarbamic acid represented by the following general formula (III): (wherein R1 and R2 independently represent a C1-C4 alkyl group and M represents an alkali metal) and a halomethane represented by the following general formula (V): CH2XmYn??(V) (wherein X and Y represent different halogen atoms, m represents 0, 1 or 2, n represents 0, 1 or 2, and m+n equals 2) for causing a reaction.

Abstract: Heterocyclic compound represented by the formula I wherein represents or the like; R1 represents hydrogen atom, C1-C6 alkyl or benzyloxy; R2 represents methyl or nil; R3 represents hydrogen atom, C1-C6 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl or —CH2R5 [wherein R5 represents phenyl (which may be substituted with C1-C6 alkyl, halogen atom or cyano)] or thienyl; R4 represents C1-C6 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl or —CH2R6 [wherein R6 represents phenyl (which may be substituted with C1-C6alkyl, halogen atom or cyano), naphtyl or thienyl]; or R3 is coupled with R4.

Abstract: An O-aryl N-(6-alkoxy-2-pyridyl)-N-alkylthiocarbamate represented by the following formula (I): (wherein R1, R2 and Ar are as defined below) is produced by treating a phenol represented by the following general formula (IV): Ar—OH ??(IV) (wherein Ar represents an aryl group) with a base in a solvent and then adding thereto an alkali metal salt of N-(6-alkoxy-2-pyridyl)-N-alkyldithiocarbamic acid represented by the following general formula (III): (wherein R1 and R2 independently represent a C1-C4 alkyl group and M represents an alkali metal) and a halomethane represented by the following general formula (V): CH2XmYn ??(V) (wherein X and Y represent different halogen atoms, m represents 0, 1 or 2, n represents 0, 1 or 2, and m+n equals 2) for causing a reaction.

Abstract: Disclosed is an method of treating cognitive impairment, including administering to a subject in need thereof a combination of a therapeutic agent for neurodegenerative disease and a therapeutically effective amount of a heterocyclic compound represented by the following general formula (I):

Abstract: A coin image simulating a coin is displayed on a television monitor synchronized with the insertion of the coin from a coin insertion portion. The coin image moves on the television monitor. When a predetermined requirement is fulfilled, the coin is paid out from a coin ejection opening. An operating object image displayed on the television monitor can be controlled with a handle that is rotatable in clockwise and counterclockwise directions.

Abstract: Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.

Abstract: Disclosed is an antidepressant, neuroprotectant, amyloid ? deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I):