Abstract: Disclosed is a fusion protein containing a brain-derived neurotrophic factor (BDNF). The fusion protein is a fusion protein of BDNF and a specific range of human anti-transferrin receptor antibody, which makes BDNF administered into the blood able to pass through the blood-brain barrier.

Abstract: The first rear image candidate determination unit determines a first rear image candidate from among first object determination images on the basis of a first evaluation value calculated by the first evaluation value calculation unit and a first evaluation criterion stored in the first evaluation criterion storage unit. For example, the first rear image candidate determination unit determines a first object determination image (which may be one or a plurality of object determination images) in which a first evaluation value equal to or greater than a first evaluation criterion has been calculated, to be the first rear image candidate.

Abstract: The first rear image candidate determination unit determines a first rear image candidate from among first object determination images on the basis of a first evaluation value calculated by the first evaluation value calculation unit and a first evaluation criterion stored in the first evaluation criterion storage unit. For example, the first rear image candidate determination unit determines a first object determination image (which may be one or a plurality of object determination images) in which a first evaluation value equal to or greater than a first evaluation criterion has been calculated, to be the first rear image candidate.

Abstract: The steering apparatus in which at least part of the transmission lines (L1, L3) which transmit the control quantity of steering from the steering wheel (20, 120, 220) to the rudder (30, 130, 230) is constituted from a steering cable such as wire so as to steer the rudder by transmitting the control quantity of operating the steering wheel to the rudder through reciprocal motion of the transmission line. The assisting force supplying means (70, 170, 270) is additionally installed and the intermediate linkage rod (60, 160, 260) is installed to interpose in the transmission line, with the transmission line (L2) for transmitting the assisting force supplied from the assisting force supplying means being connected to said intermediate linkage rod in addition to the transmission lines described above, so that the intermediate linkage rod is moved back and forth by the sum of the manual force from said steering wheel and the assisting force from the assisting force supplying means, thereby to steer the rudder.

Abstract: A helm pump (10) rotated either in forward or reverse direction by operating a steering wheel (13) and discharges a liquid of a quantity proportional to the rotating angle, and a double action cylinder moves a rudder (27) and is provided on rudder (27) side of the ship, helm pump (10) and the double action cylinder being connected with the hydraulic circuit of fully closed construction, to move the rudder (27) by an amount corresponding to the amount of liquid discharged from the helm pump (10). A second pump generates discharging pressure in the same direction as the discharging direction from helm pump (10) against resistive pressure generated by the rotation of helm pump (10) due to the operation of steering wheel (13) is installed in series in part of the fully closed hydraulic circuit, so the steering resistance of steering wheel (13) is automatically reduced by the action of the second pump.

Abstract: The steering apparatus in which at least part of the transmission lines (L1, L3) which transmit the control quantity of steering from the steering wheel (20, 120, 220) to the rudder (30, 130, 230) is constituted from a steering cable such as wire so as to steer the rudder by transmitting the control quantity of operating the steering wheel to the rudder through reciprocal motion of the transmission line. The assisting force supplying means (70, 170, 270) is additionally installed and the intermediate linkage rod (60, 160, 260) is installed to interpose in the transmission line, with the transmission line (L2) for transmitting the assisting force supplied from the assisting force supplying means being connected to said intermediate linkage rod in addition to the transmission lines described above, so that the intermediate linkage rod is moved back and forth by the sum of the manual force from said steering wheel and the assisting force from the assisting force supplying means, thereby to steer the rudder.