Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Abstract: A microorganism belonging to the genus Bacillus is cultured and thiopeptide compounds QN3323 and thiocillin I/II compounds are collected from the culture medium. The compounds are useful as drugs to treat infections caused by multidrug-resistant bacteria.

Abstract: A microorganism belonging to the genus Bacillus is cultured and novel thiopeptide compounds QN3323 and publicly known compounds thiocillin I/II, etc. are collected from the culture medium. Because of having a favorable antibacterial activity, these thiopeptide compounds are useful as drugs, in particuclar, remedies for infection with multidrug-resistant bacteria.

Abstract: To provide a wheel support bearing assembly having a capability of detecting the number of revolutions of a wheel, having no risk of breaking of wire outside a vehicle body, capable of reducing the weight and cost of an automotive vehicle. This wheel support bearing assembly for rotatably supporting a wheel 13 relative to a vehicle body structure 12 includes an outer member 1 having its inner periphery formed with plural rows of raceways 6 and 7, an inner member 2 having raceways 8 and 9 confronting respectively to the raceways 6 and 7, and rows of rolling elements 3 accommodated respectively between the raceways. An electric generator 4 for generating an electric power as one of the outer and inner members 1 and 2 rotates relative to the other of the outer and inner members 1 and 2. A signal indicative of the number of revolutions of the wheel 13 outputted from the electric generator 4 is transmitted wireless by mean of a wireless transmitting means 5A.

Abstract: To provide a wheel support bearing assembly having a capability of detecting the number of revolutions of a wheel, having no risk of breaking of wire outside a vehicle body, capable of reducing the weight and cost of an automotive vehicle. This wheel support bearing assembly for rotatably supporting a wheel 13 relative to a vehicle body structure 12 includes an outer member 1 having its inner periphery formed with plural rows of raceways 6 and 7, an inner member 2 having raceways 8 and 9 confronting respectively to the raceways 6 and 7, and rows of rolling elements 3 accommodated respectively between the raceways. An electric generator 4 for generating an electric power as one of the outer and inner members 1 and 2 rotates relative to the other of the outer and inner members 1 and 2. A signal indicative of the number of revolutions of the wheel 13 outputted from the electric generator 4 is transmitted wireless by mean of a wireless transmitting means 5A.