Patents by Inventor Kenichi Washizuka
Kenichi Washizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11566017Abstract: Provided is a cell proliferation inhibitor comprising a compound of the formula (1) or a pharmacologically acceptable salt thereof: wherein J1 and J2 each represent CH or N, with the proviso that J1 and J2 are not simultaneously CH; r represents 0 to 4; each R101 is the same or different when r is 2 or more, and R101 represents a C1-6 alkyl group optionally substituted with a halogen atom or the like; s represents 0 to 5; each R102 is the same or different when s is 2 or more, and R102 represents a halogen atom or the like; R103 represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkyl C1-6 alkyl group; and R101 and R103 are optionally linked together to form a five- to seven-membered ring hetero ring when R101 is present at the 8-position.Type: GrantFiled: December 26, 2018Date of Patent: January 31, 2023Assignees: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH, KABUSHIKI KAISHA YAKULT HONSHAInventors: Minoru Yoshida, Hiroyuki Seimiya, Yoko Yashiroda, Kenichi Washizuka, Fumiyuki Shirai, Nobuko Yoshimoto, Junichi Kazami
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Patent number: 11414429Abstract: Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.Type: GrantFiled: June 30, 2017Date of Patent: August 16, 2022Assignees: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH, KABUSHIKI KAISHA YAKULT HONSHAInventors: Minoru Yoshida, Hiroyuki Seimiya, Masayuki Okue, Yoko Yashiroda, Fumiyuki Shirai, Takeshi Tsumura, Yuko Kano, Kenichi Washizuka, Nobuko Yoshimoto, Yasuko Kouda, Takehiro Fukami, Tsubasa Chikada, Takashi Watanabe
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Publication number: 20210061789Abstract: Provided is a cell proliferation inhibitor comprising a compound of the formula (1) or a pharmacologically acceptable salt thereof: wherein J1 and J2 each represent CH or N, with the proviso that J1 and J2 are not simultaneously CH; r represents 0 to 4; each R101 is the same or different when r is 2 or more, and R101 represents a C1-6 alkyl group optionally substituted with a halogen atom or the like; s represents 0 to 5; each R102 is the same or different when s is 2 or more, and R102 represents a halogen atom or the like; R103 represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkyl C1-6 alkyl group; and R101 and R103 are optionally linked together to form a five- to seven-membered ring hetero ring when R101 is present at the 8-position.Type: ApplicationFiled: December 26, 2018Publication date: March 4, 2021Applicants: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH, KABUSHIKI KAISHA YAKULT HONSHAInventors: Minoru YOSHIDA, Hiroyuki SEIMIYA, Yoko YASHIRODA, Kenichi WASHIZUKA, Fumiyuki SHIRAI, Nobuko YOSHIMOTO, Junichi KAZAMI
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Publication number: 20210060016Abstract: To provide an anticancer agent for preventing and/or treating cancer, comprising a tankyrase inhibitor containing a tankyrase inhibitory compound and a microtubule inhibitor containing a microtubule inhibitory compound as active ingredients.Type: ApplicationFiled: December 26, 2018Publication date: March 4, 2021Applicants: JAPANESE FOUNDATION FOR CANCER RESEARCH, RIKEN, KABUSHIKI KAISHA YAKULT HONSHAInventors: Hiroyuki SEIMIYA, Minoru YOSHIDA, Yoko YASHIRODA, Yukiko MURAMATSU, Fumiyuki SHIRAI, Kenichi WASHIZUKA
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Publication number: 20200172554Abstract: Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.Type: ApplicationFiled: June 30, 2017Publication date: June 4, 2020Applicants: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCHInventors: Minoru YOSHIDA, Hiroyuki SEIMIYA, Masayuki OKUE, Yoko YASHIRODA, Fumiyuki SHIRAI, Takeshi TSUMURA, Yuko KANO, Kenichi WASHIZUKA, Nobuko YOSHIMOTO, Yasuko KOUDA, Takehiro FUKAMI, Tsubasa CHIKADA, Takashi WATANABE
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Patent number: 7928264Abstract: The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, —Z—R9 or (b), in which —Z— is —0—, —S—, R9 —SO— or —SO2—, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R10, in which -D- is —CONHSO2— or —S02NHCO—, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.Type: GrantFiled: September 20, 2005Date of Patent: April 19, 2011Assignee: Astellas Pharma Inc.Inventors: Kouji Hattori, Susumu Toda, Kenichi Washizuka, Shinji Ito, Daisuke Tanabe, Takanobu Araki, Minoru Sakurai
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Patent number: 7417060Abstract: The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.Type: GrantFiled: December 21, 2004Date of Patent: August 26, 2008Assignee: Astellas Pharma Inc.Inventors: Kouji Hattori, Susumu Toda, Masashi Imanishi, Shinji Ito, Kenichi Washizuka, Takanobu Araki, Minoru Sakurai, Daisuke Tanabe
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Publication number: 20080039506Abstract: The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R9 or (b), in which -Z- is -0-, —S—, R9—SO— or —SO2—, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R?, in which -D- is —CONHSO2— or —S02NHCO—, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.Type: ApplicationFiled: September 20, 2005Publication date: February 14, 2008Applicant: Astellas Pharma Inc.Inventors: Kouji Hattori, Susumu Toda, Kenichi Washizuka, Shinji Ito, Daisuke Tanabe, Takanobu Araki, Minoru Sakurai
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Publication number: 20070142638Abstract: Ornithine derivatives of the formula (I): wherein X is —CO— or —(CH2)k— (wherein k is 1, 2 or 3); Y is Z-(CH2)n—, and the like; {wherein Z is R1—CO—NR4—, and the like, (wherein R1 is aryl, and the like; and R4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R2 is aryl-(lower alkyl), and the like; R3 is -Q-R7, [wherein Q is —CO— or —SO2—, R is heterocyclyl], and the like; and R5 and R6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament.Type: ApplicationFiled: December 17, 2004Publication date: June 21, 2007Applicant: Astellas Pharma Inc.Inventors: Kouji Hattori, Naoaki Fujii, Akira Tanaka, Kenichi Washizuka, Minoru Sakurai
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Publication number: 20050137236Abstract: The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.Type: ApplicationFiled: December 21, 2004Publication date: June 23, 2005Applicant: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kouji Hattori, Susumu Toda, Masashi Imanishi, Shinji Ito, Kenichi Washizuka, Takanobu Araki, Minoru Sakurai, Daisuke Tanabe
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Publication number: 20050043358Abstract: A compound of the formula (I): wherein X1 is bond or —OCH2—; X2 is —(CH2)n—, in which n is 1, 2 or 3; X3 is bond, —O—, —S—, —OCH2—, or —NH—; R1 is phenyl or pyridyl each of which may have one or two substituent(s) selected from the group consisting of hydroxy, halogen, etc.; R2 is hydrogen, (lower)alkoxycarbonyl, etc.; R3 is hydroxy(lower)alkyl; halo(lower)alkyl, etc.; R4 is aryl or unsaturated heterocyclic group, each of which may have one or two substituent(s) selected from the group consisting of lower alkyl, hydroxy, carbamoyl, halogen, lower alkoxy, etc.; and a salt thereof which is useful as a medicament.Type: ApplicationFiled: December 29, 2003Publication date: February 24, 2005Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Takeshi Kato, Naoaki Fujii, Kenichi Washizuka, Yasuyo Tomishima, Hisashi Takasugi, Yutaka Kohno, Nobuhiro Yamamoto, Naoko Unami, Hirohumi Ishikawa
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Patent number: 6826033Abstract: The present invention relates to a compound formula (I) wherein X1 is bond or —O—CH2—, (II) or (III) R1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.Type: GrantFiled: March 21, 2003Date of Patent: November 30, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Minoru Sakurai, Kenichi Washizuka, Hitoshi Hamashima, Yasuyo Tomishima, Masashi Imanishi, Yutaka Nakajima, Hiroaki Ohtake, Satoru Kuroda, Masayoshi Murata, Hiroshi Kayakiri, Naoaki Fujii, Kiyoshi Taniguchi
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Publication number: 20040138462Abstract: The present invention relates to a compound formula wherein R1 is phenyl, pyridyl, etc., each of which may be substituted with one or two substituent(s); R2 is hydrogen, an amino protective group, etc.; R3 and R4 are each independently hydrogen, lower alkyl or hydroxy(lower)alkyl; R5 is aryl, ar(lower)alkyl, etc., each of which may be substituted with one, two or three substituent(s); R8 is hydrogen or halogen, X is a single bond or O—CH2—, and n is 0, 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.Type: ApplicationFiled: November 24, 2003Publication date: July 15, 2004Inventors: Minoru Sakurai, Kenichi Washizuka, Hitoshi Hamashima, Yasuyo Tomishima, Masashi Imanishi, Hiroshi Kayakiri, Kiyoshi Taniguchi, Fujiko Takamura
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Publication number: 20040037022Abstract: The present invention relates to a compound formula (I) wherein X1 is bond or —O—CH2—, (II) or (III) R1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.Type: ApplicationFiled: March 21, 2003Publication date: February 26, 2004Inventors: Minoru Sakurai, Kenichi Washizuka, Hitoshi Hamashima, Yasuyo Tomishima, Masashi Imanishi, Yutaka Nakajima, Hiroaki Ohtake, Satoru Kuroda, Masayoshi Murata, Hiroshi Kayakiri, Naoaki Fujii, Kiyoshi Taniguchi
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Publication number: 20030073846Abstract: A compound of the formula (I) wherein X1 ? is bond or —O(CH2)m— (in which m is an integral number of 1, 2 or 3); X2 is bond, —(CH2)n—, etc. (in which n is an integral number of 1, 2 or 3); R1 is hydrogen or amino protective group; R2 is hydroxy(lower)alkyl or (lower)alkoxy(lower)alkyl; A is phenyl, pyridyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, lower alkyl, etc.; and B is phenyl or pyridyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, nitro, etc.; and a pharmaceutically acceptable salt thereof which is useful as a medicament.Type: ApplicationFiled: August 6, 2002Publication date: April 17, 2003Inventors: Kiyoshi Taniguchi, Hiroshi Kayakiri, Minoru Sakurai, Naokaki Fujii, Kenichi Washizuka, Hitoshi Hamashima, Yasuyo Tomishima, Kaori Hamada, Nobuhiro Yamamoto, Hirofumi Ishikawa, Naoko Unami, Toshiko Miura
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Publication number: 20030032834Abstract: A compound of the formula [Ig]; wherein R1 is hydrogen or an amino protective group, R2 is hydrogen or hydroxy, and R3 and R4 are independently N-methyl-methoxycarbonylamino, N-ethyl-methoxycarbonylamino, N-propyl-methoxycarbonylamino or 3-ethylureid, or R3 and R4 are both methoxycarbonylamino substituted at a meta position of the benzene rings, or a salt thereof, and (2S)-1-phenoxy-3-[3,3-bis[4-methoxycarbonylamino)-phenyl]propylamino]-2-propanol sulfate (2:1) and some crystal forms thereof as &bgr;3adrenergic receptor agonists.Type: ApplicationFiled: August 19, 2002Publication date: February 13, 2003Inventors: Hiroshi Kayakiri, Naoaki Fujii, Hitoshi Hamashima, Minoru Sakurai, Kenichi Washizuka, Yasuyo Tomishima, Kiyoshi Taniguchi, Naoko Unami, Yutaka Kono, Hirofumi Ishikawa, Nobuhiro Yamamoto, Hisashi Mimura
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Publication number: 20020143034Abstract: A compound of the formula (I): 1Type: ApplicationFiled: April 10, 2002Publication date: October 3, 2002Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Takeshi Kato, Naoaki Fujii, Kenichi Washizuka, Yasuyo Tomishima, Hisashi Takasugi, Yutaka Kohno, Nobuhiro Yamamoto, Naoko Unami, Hirohumi Ishikawa
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Patent number: 5241064Abstract: Preparation of optically active 3-substituted azetidinones of the formula (I) ##STR1## in which R.sup.1 is a hydroxy-protective group wherein an allylic alcohol of the formula (II) ##STR2## is acylated, then subjected to asymmetric enzymatic hydrolysis yielding the R-allylic alcohol. The hydroxyl group is protected and then stereoselectively reacted with an amine which is subsequently cyclized to yield the desired 3-substituted azetidinone. Two new species of microorganisms have been isolated, Pimelobacter sp. No. 1254 and Bacillus megaterium No. 1253 which exhibit stereoselective esterase activity.Type: GrantFiled: September 24, 1990Date of Patent: August 31, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masayoshi Murata, Toshiyuki Chiba, Fumiyuki Shirai, Kenichi Washizuka, Motohiro Hino