Abstract: The present disclosure provides, for example, a method of stabilizing the RAF/MEK complex in a subject, the method comprising administering to the subject an effective amount of a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or —N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group.

Abstract: An estimation apparatus includes an input unit and an approximator. Input information including an image in which a bone appears is input into the input unit. The approximator is configured to determine an estimation result related to bone density of the bone from the input information. The approximator includes a learned parameter to obtain the estimation result.

Abstract: A semiconductor device includes a substrate; a first insulating layer provided on the substrate; a first metal layer provided on the first insulating layer; a second metal layer provided on the first metal layer; and a second insulating layer covering the first metal layer and the second metal layer. An upper surface of the first metal layer has a first region that is in contact with the second metal layer, and a second region that is separated from the second metal layer. The second insulating layer is in direct contact with a side surface and the second region of the first metal layer and an upper surface and a side surface of the second metal layer. A width of the first metal layer is greater than or equal to a width of the second metal layer in a direction parallel to the substrate.

Abstract: A method for manufacturing a press-molded article includes: preparing a patchwork blank in which a thickened portion is formed by welding patchwork to basework; bending only the thickened portion of the patchwork blank; and bending a portion other than the thickened portion in a step different from bending of the thickened portion.

Abstract: A vehicle body structure includes a battery disposed in a lower central part of a vehicle body, a hollow side sill extending in a vehicle front-rear direction and disposed outside the battery in a vehicle width direction, and a reinforcing member configuring at least a part of a continuous tubular structure formed inside the side sill. The continuous tubular structure has a shape in which a plurality of octagons are continuously arranged as viewed from the vehicle width direction.

Abstract: A user is presented with determination information obtained by determining a condition of a target site and feature information indicating a feature related to a condition of a body of a subject, which are generated from the same image representing the target site of the subject. A determination system includes an acquirer that acquires a target image representing a target site of a body of a subject, a first generator that generates first determination information indicating a condition of the target site from the target image used to generate the first determination information, a second generator that generates feature information indicating a feature related to a condition of the body of the subject from the target image, and a display controller that causes a display apparatus to display the first determination information and the feature information.

Abstract: A prediction image is generated and output that represents a condition of a target region of a subject. A prediction system includes a prediction information acquirer that acquires (a) a subject image representing a target region of a subject at a first time, and (b) first prediction information regarding the target region at a second time when a predetermined period has elapsed from the first time; and a prediction image generation unit that generates a prediction image indicating a condition of the target region at the second time from the subject image based on the first prediction information and output the prediction image.

Abstract: Provided is a composite material having an excellent antibacterial property and a reduced elution of fluorine. A composite material according to the present disclosure includes a base material and a surface layer located at a surface of the base material. The surface layer contains a compound of titanium and fluorine and a compound of titanium, fluorine, and oxygen. An abundance of the compound of titanium and fluorine in the surface layer does not exceed an abundance of the compound of titanium, fluorine, and oxygen in the surface layer.

Abstract: A method for manufacturing a metal-resin composite includes preparing a mold including a first mold forming a housing portion and a second mold movable with respect to the first mold, housing an extruded material in the housing portion, arranging resin material on the first mold, moving the second mold to form a cavity defined by the extruded material and the mold, and filling the cavity with the resin material. In the filling, a protrusion of the extruded material is brought into close contact with the housing portion or its peripheral edge by molding pressure applied from the mold to the extruded material, and the cavity is disconnected from a gap between an inner surface of the housing portion and the extruded material.

Abstract: A metal-resin composite includes: a metal plate including at least one cut-and-raised portion including a cutout hole and a cut-and-raised piece; and a resin material disposed only on one surface side of the metal plate, the resin material cured by burying the cut-and-raised portion, the resin material integrated with the metal plate.

Abstract: To provide a control board for efficiently generating electric energy in a power generating device from heat generated from an electronic device. A control board includes a board including a first heat dissipating pad; an electronic device including a second heat dissipating pad to dissipate heat; a power generating device including a Peltier device which converts heat energy generated from the electronic device into electric energy, wherein the power generating device is sandwiched between the first heat dissipating pad and the second heat dissipating pad; and a power supply circuit configured to reuse the electric energy.

Abstract: A capacitive isolation type power conversion device includes a primary side circuit, which includes switching elements, a first connection line and a second connection line, which are connected to the primary side circuit, a first capacitor provided on the first connection line, a second capacitor provided on the second connection line, a third connection line, an excitation inductor provided on the third connection line, a secondary side circuit, and a control circuit. The control circuit controls a switching frequency, thereby controlling an output voltage, which is a voltage of DC power output from the secondary side circuit.

Abstract: An apparatus is configured to manufacture a metal-resin composite by press-molding a metal plate and a resin material. The apparatus includes an upper mold and a lower mold for sandwiching the metal plate and the resin material, and an elastic member attached to a molding surface of the lower mold. A cavity for disposing the resin material is provided by the upper mold and the lower mold. The elastic member is disposed to seal the resin material into the cavity by pressing the metal plate against the upper mold.

Abstract: A controller includes a plurality of communication interfaces, a first arbiter, and a second arbiter. The first arbiter arbitrates access to a memory. The second arbiter is disposed between the plurality of communication interfaces and the first arbiter. In response to reception of a plurality of outstanding read requests to the memory from one of the plurality of communication interfaces, the second arbiter limits the number of outstanding read requests to transmit to the first arbiter.

Abstract: A method for manufacturing a joint structure formed by joining a first plate-shaped member and a second plate-shaped member having a shape that is longer in a longitudinal direction than in a lateral direction includes overlapping the first plate-shaped member and the second plate-shaped member, after the overlapping, joining each of both edge portions of the second plate-shaped member by forming a weld metal along the longitudinal direction to the first plate-shaped member. The weld metal extends further outward in the lateral direction than the edge portions of the second plate-shaped member, in which the weld metal is formed by a hybrid welding in which a laser is added as a heat source during arc welding such that the weld metal extends around both of the edge portions of the second plate-shaped member along the longitudinal direction.

Abstract: Disclosed herein is an apparatus that includes: first and second wiring patterns extending in a first direction, first and second transistors arranged adjacent to each other, and third to sixth wiring patterns extending in a second direction. The third wiring pattern is connected between the first wiring pattern and one of source/drain regions of the first transistor, the fourth wiring pattern is connected between the second wiring pattern and other of source/drain regions of the first transistor, the fifth wiring pattern is connected to one of source/drain regions of the second transistor, the fifth wiring pattern overlapping with the first wiring pattern, the sixth wiring pattern is connected to other of source/drain regions of the second transistor, the sixth wiring pattern overlapping with the second wiring pattern. The third and fourth wiring patterns are greater in width in the first direction than the fifth and sixth wiring patterns.

Abstract: A molding method of an overlapped blank includes: preparing an overlapped blank including a first metal plate including a bulged excess portion, a first flat portion provided adjacent to the excess portion, and a second flat portion provided adjacent to the excess portion on an opposite side to the first flat portion, a flat second metal plate overlapped on the first flat portion and the second flat portion, a first joint portion where the first flat portion and the second metal plate are joined to each other, and a second joint portion where the second flat portion and the second metal plate are joined to each other; and bending the overlapped blank with the first metal plate being directed to an outer side of the bending of the overlapped blank.

Abstract: A prediction device includes a first prediction unit that outputs first prediction information regarding a joint at a second point in time after a predetermined period of time from a first point in time, from a medical image showing the joint of a subject at the first point in time. The first prediction unit includes a first prediction model capable of estimating the first prediction information from the medical image.

Abstract: Molding accuracy of a metal member is improved in an apparatus, a mold set, and a method for producing a metal-resin composite with a set of molds. An apparatus for manufacturing a metal-resin composite by press molding a metal member and a resin material, the apparatus including a mold including an upper mold and a lower mold sandwiching the metal member and the resin material, a molding auxiliary component detachably fixed to the upper mold so as to fill at least a part of a cavity C for arranging the resin material formed by the upper mold and the lower mold, and a drive unit that moves at least one of the upper mold and the lower mold in a vertical direction. The molding auxiliary component has a first press surface for molding the metal member. The upper mold has a second press surface for integrally molding the metal member and the resin material.

Abstract: A joint body includes first and second metal members and a joint portion including a welded portion where the first and second metal members are joined together, the welded portion having a line shape. The joint portion includes first and second longitudinal portions and a plurality of connecting portions. The first longitudinal portion has first intersecting portions arranged in a first direction and extends in the first direction. The second longitudinal portion has second intersecting portions arranged in the first direction and extends in the first direction. The welded portion intersects itself at the first and second intersecting portions. The connecting portions are arranged in the first direction. The connecting portions extend in a first direction and connect the first and second longitudinal portions.