Abstract: The auto-sampler for chromatographs includes a needle for sampling configured to move while a tip end thereof faces vertically downward; a switching valve having a plurality of ports to which channels constituting a chromatograph are connected, the switching valve switching between port connecting conditions to switch between channel configurations; and an injection port including an opening at an upper surface thereof through which a tip end of the needle is inserted to make the needle fluidically communicate with a pipe connected to one port of the switching valve, and a needle seal configured to get into contact with an outer circumferential surface of the tip end portion to make the needle fluidically communicate with the pipe in a liquid-tight manner when the tip end of the needle is inserted through the opening.

Abstract: Provided is a cover member (33, 36, 50) for covering an opening of a sample container in which a liquid sample is to be contained. To accurately collect the liquid sample contained in the sample container while preventing a carryover, the cover member is made of an elastic sheet material and has a slit (331, 361, 511) in an area different from a predetermined area through which a sample-collecting tool for collecting the liquid sample is to be inserted. This cover member can be suitably used as a septum configured to cover an opening of a vial, or as a sheet configured to cover openings of a plurality of wells provided on a microplate.

Abstract: The auto-sampler for chromatographs includes a sampling needle, a pipe, a pump portion, and a connecting mechanism configured to connect the sampling needle and the pipe. The connecting mechanism includes a first component fixed to the sampling needle, a second component fixed to the pipe, a fixing component, and a packing. The fixing component fixes the first component and the second component using screwing of screws while the end surface of the sampling needle and the end surface of the pipe are in contact with the packing. As a result, dead volume at the connecting portion between the sampling needle and the pipe is reduced.

Abstract: A bioinert piping (1) that has a flow path (2) provided inside and a main body portion (10) between end portions (8, 8) includes a resin tube (4) that forms an inner wall of the flow path (2) over an entire length of the flow path (2), and a metal tube (6) that accommodates the resin tube (4) inside so as to cover the outer peripheral surface of the resin tube (4) over at least an entire length of the main body portion (10). The metal tube (6) is plastically deformed toward an inner side so that the outer peripheral surface of the resin tube (4) and an inner peripheral surface of the metal tube (6) are in liquid-tight contact with each other.

Abstract: A resin tube connection device includes a resin tube, a resin expanding portion and a metal sleeve. The resin expanding portion has a sealing surface being able to come into contact with a contact surface. Further, the resin expanding portion has a second flow path that communicates with a first flow path of the resin tube and opens in the sealing surface. The sealing surface projects farther than an end surface of the metal sleeve in an axial direction. The maximum length of a contact region where the resin expanding portion and the metal sleeve come into contact with each other in the axial direction in an outer surface is larger than the thickness of a resin layer in a radial direction.

Abstract: A sample rack includes a placement table having an upper surface for placing at least one sample plate thereon, a handle portion holding a proximal end portion of the placement table, the handle portion having a lower end portion positioned lower than a lower surface of the placement table when the upper surface is leveled, and a leg portion attached to the placement table to take a protruding posture in which the leg portion is protruded downward from the lower surface and a storage posture in which the leg portion is not protruded downward from the lower surface. The leg portion is configured to support the sample rack to maintain the upper surface substantially horizontally in cooperation with the lower end portion of the handle portion when the sample rack is placed on a substantially horizontal surface with the leg portion taking the protruding posture.

Abstract: A pump unit includes a pump and a metal ion trap. The pump includes a metal member that comes into contact with a mobile phase. The pump pumps a mobile phase through a flow path. The metal ion trap includes a filter element. The filter element includes a metal ion retention structure for retaining metal ions by interacting with the metal ions included in a mobile phase. The filter element is provided in the flow path for a mobile phase pumped by the pump. The pump unit may be provided in a chromatograph.

Abstract: An autosampler is switched selectively between an injecting mode where a sampling flow path is incorporated into an analysis flow path of a liquid chromatograph and a loading mode where the sampling flow path is not incorporated into the analysis flow path and injects a sample into the analysis flow path at a position farther upstream than a separation column by being switched to the injecting mode with the sample held in the sampling flow path, and includes a clog determiner configured to acquire a sending liquid pressure of a liquid sending pump that sends a mobile phase in the analysis flow path, obtain a variation value of the liquid sending pressure when the injecting mode and the loading mode are switched and determine presence or absence of a clog in a system incorporated into the analysis flow path in the injecting mode based on the obtained variation value.

Abstract: A bioinert pipe includes a flow path inside, an inner wall of the flow path is composed of a resin tube and an outer peripheral surface of the resin tube is covered with a metal tube. The bioinert pipe includes an end portion extension member attached to an end portion of the metal tube, and the end portion extension member is made from a material harder than the resin tube and has a first surface and a second surface. The first surface is facing and in contact with an end surface of the metal tube and the second surface is directed opposite to the first surface. a through hole having an inner diameter substantially the same as an inner diameter of the metal tube is provided so as to pass from the first surface to the second surface in the end portion extension member. An edge of the through hole on the second surface of the end portion extension member has a chamfered shape, and the resin tube is inserted into the through hole.

Abstract: A bioinert piping (1) that has a flow path (2) provided inside and a main body portion (10) between end portions (8, 8) includes a resin tube (4) that forms an inner wall of the flow path (2) over an entire length of the flow path (2), and a metal tube (6) that accommodates the resin tube (4) inside so as to cover the outer peripheral surface of the resin tube (4) over at least an entire length of the main body portion (10). The metal tube (6) is plastically deformed toward an inner side so that the outer peripheral surface of the resin tube (4) and an inner peripheral surface of the metal tube (6) are in liquid-tight contact with each other.

Abstract: The auto-sampler for chromatographs includes a sampling needle, a pipe, a pump portion, and a connecting mechanism configured to connect the sampling needle and the pipe. The connecting mechanism includes a first component fixed to the sampling needle, a second component fixed to the pipe, a fixing component, and a packing. The fixing component fixes the first component and the second component using screwing of screws while the end surface of the sampling needle and the end surface of the pipe are in contact with the packing. As a result, dead volume at the connecting portion between the sampling needle and the pipe is reduced.

Abstract: The auto-sampler for chromatographs includes a needle for sampling configured to move while a tip end thereof faces vertically downward; a switching valve having a plurality of ports to which channels constituting a chromatograph are connected, the switching valve switching between port connecting conditions to switch between channel configurations; and an injection port including an opening at an upper surface thereof through which a tip end of the needle is inserted to make the needle fluidically communicate with a pipe connected to one port of the switching valve, and a needle seal configured to get into contact with an outer circumferential surface of the tip end portion to make the needle fluidically communicate with the pipe in a liquid-tight manner when the tip end of the needle is inserted through the opening.

Abstract: A resin tube is prepared. Further, a formation tool having a pressing surface and a projection that projects from the pressing surface and is insertable into the resin tube is prepared. The projection of the formation tool is inserted from an end of the resin tube into the resin tube. The pressing surface of the formation tool is pressed against an end surface of the resin tube. Thermal energy is applied to the end of the resin tube, whereby a shape of the pressing surface of the formation tool is transferred to the end surface of the resin tube, and the end of the resin tube is formed into a flange shape.

Abstract: An autosampler is switched selectively between an injecting mode where a sampling flow path is incorporated into an analysis flow path of a liquid chromatograph and a loading mode where the sampling flow path is not incorporated into the analysis flow path and injects a sample into the analysis flow path at a position farther upstream than a separation column by being switched to the injecting mode with the sample held in the sampling flow path, and includes a clog determiner configured to acquire a sending liquid pressure of a liquid sending pump that sends a mobile phase in the analysis flow path, obtain a variation value of the liquid sending pressure when the injecting mode and the loading mode are switched and determine presence or absence of a clog in a system incorporated into the analysis flow path in the injecting mode based on the obtained variation value.

Abstract: A liquid chromatograph includes a plurality of columns, fluid supply units each configured to feed a predetermined solution in parallel with inlet side flow paths of the plurality of columns, a sample injection unit capable of selectively injecting a sample into one of the inlet side flow paths of the plurality of columns, and a flow path switching unit disposed on exit sides of the plurality of columns and configured to selectively connect one of outlet side flow paths of the plurality of columns to a flow path connected to a detector arranged on a downstream side of the flow path switching unit and connect outlet side flow paths of other columns to a waste liquid flow path. The liquid chromatograph may improve a throughput by shortening a time required for a series of measurements in which a sample is measured under a plurality of conditions by alternatively using a plurality of columns.

Abstract: A sample rack is provided with a placement table having an upper surface for placing at least one sample plate thereon, a handle portion holding a proximal end portion of the placement table, the handle portion having a lower end portion positioned lower than a lower surface of the placement table when the upper surface of the placement table is leveled, and a leg portion attached to the placement table and configured to take a protruding posture in which the leg portion is protruded downward from the lower surface of the placement table and a storage posture in which the leg portion is not protruded downward from the lower surface of the placement table. The leg portion is configured to support the sample rack to maintain the upper surface of the placement table substantially horizontally in cooperation with the lower end portion of the handle portion when the sample rack is placed on a substantially horizontal surface in a state in which the leg portion takes the protruding posture.

Abstract: An autosampler is provided with a needle, syringe pump, needle drive mechanism, sample loop, and flow path switching mechanism. The flow path switching mechanism has a plurality of solvent delivery flow paths that each deliver a different solvent, an analysis flow path that is in communication with an analysis column for separating a sample, and a plurality of connection ports to which the ends of the sample loop are individually connected, and switches, by switching the Connection state between the connection ports, to either a loading mode for connecting all the solvent delivery flow paths to the analysis flow path without interposing the sample loop or an injecting mode for interposing the sample loop between all the solvent delivery flow paths and the analysis flow path.

Abstract: An autosampler is provided with a needle, syringe pump, needle drive mechanism, sample loop, and flow path switching mechanism. The flow path switching mechanism has a plurality of solvent delivery flow paths that each deliver a different solvent, an analysis flow path that is in communication with an analysis column for separating a sample, and a plurality of connection ports to which the ends of the sample loop are individually connected, and switches, by switching the Connection state between the connection ports, to either a loading mode for connecting all the solvent delivery flow paths to the analysis flow path without interposing the sample loop or an injecting mode for interposing the sample loop between all the solvent delivery flow paths and the analysis flow path.

Abstract: An autosampler is provided with a needle that has a capacity to retain a sample therein and has both ends each formed in a pointed shape, a first adapter that has an opening and causes the needle and a syringe pump to be in communication with each other through the insertion of the upper end part of the needle into the opening, and a second adapter that connects the needle and a mobile-phase liquid-delivery flow path using a structure similar to that of the first adapter. The autosampler is configured such that the first adapter and the second adapter are attached to and removed from the upper end part of the needle so as to create flow paths including the needle as necessary and carry out a sampling operation and injecting operation.

Abstract: [Purpose] To improve a throughput by shortening a time required for a series of measurements in a liquid chromatograph in which a sample is measured under a plurality of conditions by alternatively using a plurality of columns [Solving means] Provided is a liquid chromatograph including a plurality of columns 17 and 27, fluid supply units 11 and 21 each configured to feed a predetermined solution in parallel with inlet side flow paths of the plurality of columns 17 and 27, a sample injection unit 70 capable of selectively injecting a sample into one of the inlet side flow paths of the plurality of columns 17 and 27, and a flow path switching unit 100 disposed on exit sides of the plurality of columns 17 and 27 and configured to selectively connect one of outlet side flow paths of the plurality of columns 17 and 27 to a flow path connected to a detector 101 arranged on a downstream side of the flow paths switching unit 100 and connect outlet side flow paths of other columns to a waste liquid flow path.